Evaluation of brain toxicity following near infrared light exposure after indocyanine green dye injection

Keller, Emanuela; Ishihara, Hideyuki; Nadler, Andreas; Niederer, Peter F.; Seifert, Burkhardt; Yonekawa, Yasuhiro; Frei, Karl

doi:10.1016/s0165-0270(02)00044-4

Cited by 40 publications

(30 citation statements)

References 54 publications

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“…In the study by Keller et al the process of ICG extravasation in the brain caused by disruption of the blood brain barrier was investigated [40]. It was shown on a rat model that the blood brain barrier disruption did not lead to accumulation of the ICG in the neuronal tissue.…”

Section: Discussionmentioning

confidence: 99%

“…We have analysed the content of the monomers of ICG in the H 2 O solution by derivation of monomer to oligomers ratio from the absorbance signal. In this analysis the amplitude of the spectra at 775 nm was considered as a measure of concentration of the monomers and the absorbance at wavelength of 705nm was used as a measure of concentration of oligomers [40]. It can be noted that ICG at 25 μM concentration in water is almost monomeric.…”

Section: Icg Oligomerisation Studymentioning

confidence: 99%

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Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Toczyłowska

Ziemińska

Goch

et al. 2014

Biomed. Opt. Express

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Abstract:The aim of this study was to examine neurotoxicity indocyanine green (ICG). We assessed viability of primary cerebellar granule cell culture (CGC) exposed to ICG to test two mechanisms that could be the first triggers causing neuronal toxicity: imbalance in calcium homeostasis and the degree of oligomerization of ICG molecules. We have observed this imbalance in CGC after exposure to 75-125μΜ ICG and dose and application sequence dependent protective effect of Gadovist on surviving neurons in vitro when used with ICG. Spectroscopic studies suggest the major cause of toxicity of the ICG is connected with oligomers formation. ICG at concentration of 25 μM (which is about 4 times higher than the highest concentration of ICG in the brain applied in in-vivo human studies) is not neurotoxic in the cell culture. Orlock, and C. A. Puliafito, "Adverse reactions due to indocyanine green," Ophthalmology 101(3), 529-533 (1994). 2. B. F. Hochheimer, "Angiography of the retina with indocyanine green," Arch. Ophthalmol. 86(5), 564-565 (1971). 3. J. Fishbaugh, "Retina: indocyanine green (ICG) angiography," Insight 19(3), 30-32 (1994). 4. J. Caesar, S. Shaldon, L. Chiandussi, L. Guevara, and S. Sherlock, "The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function," Clin. Sci. 21, 43-57 (1961). 5. A. El-Desoky, A. M. Seifalian, M. Cope, D. T. Delpy, and B. R. Davidson, "Experimental study of liver dysfunction evaluated by direct indocyanine green clearance using near infrared spectroscopy," Br. J. Surg. 1005-1011 (1999). 6. T. Ishizawa, N. Fukushima, J. Shibahara, K. Masuda, S. Tamura, T. Aoki, K. Hasegawa, Y. Beck, M. Fukayama, and N. Kokudo, "Real-time identification of liver cancers by using indocyanine green fluorescent imaging," Cancer 115(11), 2491-2504 (2009 4998-5003 (2006). 17. T. L. Jackson, "Indocyanine green accused," Br. J. Ophthalmol. 89(4), 395-396 (2005). Reson. Imaging 14(6), 619-623 (1996). 77. D. E. Ray, J. B. Cavanagh, C. C. Nolan, and S. C. Williams, "Neurotoxic effects of gadopentetate dimeglumine: behavioral disturbance and morphology after intracerebroventricular injection in rats," AJNR Am. J. Neuroradiol. 17(2), 365-373 (1996). 78. X. Feng, Q. Xia, L. Yuan, X. Yang, and K. Wang, "Impaired mitochondrial function and oxidative stress in rat cortical neurons: implications for gadolinium-induced neurotoxicity," Neurotoxicology 31(4), 391-398 (2010). 79. M. P. Mattson and Y. Goodman, "Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium," Brain Res. 676(1), 219-224 (1995). 86(8),

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Section: Discussionmentioning

confidence: 99%

Section: Icg Oligomerisation Studymentioning

confidence: 99%

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Toczyłowska

Ziemińska

Goch

et al. 2014

Biomed. Opt. Express

View full text Add to dashboard Cite

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“…The dye ICG itself has been approved by the United States Food and Drug Administration and is often used for medical diagnosis [9][10][11][12]. An advantage of ICG is the presence of an absorption maximum near the isobestic point at a wavelength of 805 nm, where oxy-Hb and deoxy-Hb show the same absorption characteristics.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

Mudra

Muroi

Niederer

et al. 2008

Opto-Electronics Review

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The cerebral blood flow (CBF) is an important vital parameter in neurointensive care. Currently, there is no non-invasive method for its measurement that can easily be applied at the bedside. A new tool to determine CBF is based on near-infrared spectroscopy (NIRS) applied together with indocyanine green (ICG) dye dilution. From a bilateral measurement on selected regions on the head of infrared (IR) absorption at various wavelengths during the dilution maneuver, the vascular perfusion characteristics of the two brain hemispheres can be determined in terms of mean transit time (mtt) of ICG, cerebral blood volume (CBV) and CBF.So far, on nine healthy volunteers, NIRS ICG dye dilution bihemispheric measurements were performed, which yielded to mtt given as median (range) of 9.3 s (5.1–16.3 s), CBV of 3.5 ml/100 g (1.7–4.1 ml/100 g), and CBF of 18.2 ml/(100 g×min) [11.1–48.6 ml/(100 g×min)]. Additionally, the blood flow index (BFI) was calculated with BFI= 13.8 mg/(100 g×s) [6.6–15.2 mg/(100 g×s)]. The Spearman rank correlation coefficient between CBF and BFI was RS = 0.76. However, as the Bland & Altman plot between CBFNIRS and the CBFBFI documents, the limits of agreement are rather wide (21.9±6.7). Under physiological conditions in healthy volunteers, no differences could be detected between the hemispheres.

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“…After intravenous injection of ICG, the NeMo Probe facilitates serial measurements of the mean transit time of the dye (mttICG), cerebral blood volume (CBV), and CBF (12,13). Previous studies have shown that ICG administration followed by near-infrared light exposure is safe when applied for CBF monitoring in animals with disrupted blood-brain barrier (14). In addition, preliminary case reports using scientific prototypes showed the feasibility and proof of concept of the NIRS-ICG method in patients with acute brain injury (11, 15 16).…”

Section: Introductionmentioning

confidence: 98%

Evaluation of a New Brain Tissue Probe for Cerebral Blood Flow Monitoring in an Experimental Pig Model

et al. 2016

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Background: Bedside monitoring of cerebral blood flow (CBF) may provide new insights into the pathophysiology of brain injury, allow early detection of secondary ischemia, and help guide therapy. Objective: To evaluate a new brain tissue probe for serial CBF monitoring using near-infrared spectroscopy Indocyanine green dye dilution (NeMo Probe) com-pared with the existing thermal diffusion probe (QFlow 500 Probe). Methods: In 7 pigs, the NeMo Probe and QFlow 500 Probe were inserted into the subcortical white matter. Parallel measurements were recorded during [1] baseline, [2] hypotension, [3] hypertension, and [4] hyperventilation. Thereafter, protocol points 1 through 4 were repeated once. The Spearman correlation (rs), Bland-Altman plot, concordance rate, and coefficient of variation were used for statistical analysis. Results: There was poor agreement between 56 pairs of absolute CBF values (rs = 0.52, P < .001). The mean bias was 10.7 ml/100 g/min with limits of agreement of 233.0 to·54.3 ml/100 g/min. The analysis of 49 pairs of changes in CBF showed a good·correlation (rs = 0.83, P <.001), and the concordance rate was 93.3%. The coefficient of variation from repeated measurements under comparable physiological conditions was 51.6% for the QFlow 500 Probe and 12.9% for the NeMo Probe. Conclusion: Absolute CBF values obtained with the NeMo Probe and QFlow 500 Probe cannot be interpreted as equivalent. However, the NeMo Probe provides acceptable trending ability and reproducibility from repeated measurements, whereas the reproducibility of the QFlow 500 Probe was poor. Future clinical studies are warranted to evaluate the NeMo Probe in the setting of acute brain injury.

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Evaluation of brain toxicity following near infrared light exposure after indocyanine green dye injection

Cited by 40 publications

References 54 publications

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

Evaluation of a New Brain Tissue Probe for Cerebral Blood Flow Monitoring in an Experimental Pig Model

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