Evaluation of buparvaquone (BUTA-Kel™ KELA, Belgium) as a treatment of East Coast fever in cattle, in the peri-urban of Dar Es Salaam city, Tanzania

Mbwambo, H.; Magwisha, H.B.; Mfinanga, J.M

doi:10.1016/j.vetpar.2006.02.024

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…However, a relatively low tick burden (<10 ticks /animal) was recorded in animals with a suspicion of ECF. Buparvaquone (Butalex®) and Parvaquone (Clexon®, Parvaxone®) were used to treat ECF cases (Dolan 1986;Mbwambo et al 2002Mbwambo et al , 2006. However, these drugs were expensive and not readily available in North Kivu.…”

Section: Introductionmentioning

confidence: 99%

Identification of hard ticks (Acari: Ixodidae) and seroprevalence to Theileria parva in cattle raised in North Kivu Province, Democratic Republic of Congo

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Identification of hard ticks (Acari: Ixodidae) and seroprevalence to Theileria parva in cattle raised in North Kivu Province, Democratic Republic of Congo

et al. 2012

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“…in different ages of cattle, the use of buparvaquone in conjunction with oxytetracycline has been reported to achieve a treatment rate of over 90% (18). Another study found it to be effective at a rate of 95.2% (19). Successful treatment of Theileriosis in cattle and calves has been reported using buparvaquone, meloxicam, vitamins (A, E, D3, Biotin), and flumethrin applications (20).…”

Section: Usage Of Buparvaquonementioning

confidence: 99%

Buparvaquone

USLU,

CANBAR

2023

Bozok Veterinary Sciences

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Theileriosis is a type of blood protozoan infection caused by the transmission of Theileria spp. species in tropical and subtropical regions by ticks belonging to the Ixodidae family. The disease progresses with high mortality and morbidity especially in ruminants. While deaths are observed in the first few days in peracute cases, it is reported that deaths are observed within the first weeks in acute cases. Fever, lymphadenopathy, respiratory distress, increase in heart rate, decrease in milk yield, weight loss, abortion and death are observed in patients. Buparvaquone, an antiprotozoal drug of the hydroxynaphthoquinone group, is the single most effective drug used in the treatment of the disease. Although it is recommended to use 2.5 mg/kg intramuscularly against theileriosis infection in cattle, it can be used in the same dosage regimen 2-3 days later if deemed necessary by the physician. In case of use of the drug, local reactions may develop in the area where it is applied, and it is not recommended to be used with vaccines and in pregnant animals. The drug is generally considered safe. Since the disease is transmitted by ticks, it is recommended to add an ectoparasitic agent to the treatment protocol. In this review, it has been tried to give information about the use of buparvaquone in the treatment of theileriosis.

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“…However, late stage treatment did eliminate the protozoal parasites from the blood and lymph nodes, it failed to improve the clinical condition of the affected animals, possibly due to irreversible damage to the lungs. Gharbi et al [35] reported that buparvaquone produces 86.66% clinical efficacy against Theileria annulata, but 97.1% and 95.2% efficacy against Theileria parva [36]. Bilgic et al [36] reported that the late treated cases failed to control by the drug buparvaquone due to the production of pulmonary edema.…”

Section: Therapeutic Aspectmentioning

confidence: 99%

“…Gharbi et al [35] reported that buparvaquone produces 86.66% clinical efficacy against Theileria annulata, but 97.1% and 95.2% efficacy against Theileria parva [36]. Bilgic et al [36] reported that the late treated cases failed to control by the drug buparvaquone due to the production of pulmonary edema.…”

Section: Therapeutic Aspectmentioning

confidence: 99%

Bovine Tropical Theileriosis: An Update

Tripathi¹,

Jaiswal²

2022

Infectious Diseases

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Tick-borne diseases (TBDs) cause major economic losses and affect many domestic animals, mainly cattle and sheep, in tropical and subtropical regions. Tropical theileriosis is a TBD caused by a protozoon called Theileria annulata transmitted by several tick species of the genus Hyalomma. Clinical manifestations of theileriosis are expressed mainly as anorexia, febrile generalized lymphadenitis and anemia followed by lethargy, lacrimation, nasal discharge and exopthalmia. Anemia is a feature point in tropical bovine theileriosis and severity was positively related to parasitaemia rates. Fatality due to infection is greatly dependent on the overproduction of cytokines, such as TNF-α produced by the schizont-infected monocytes/macrophages and uninfected macrophages. Buparvaquone gave 86.66% clinical efficacy against Theileria annulata, but 97.1% and 95.2% efficacy against Theileria parva. In Theileriosis, hemolysis occurs due to isoantibody to RBC. To prevent this isoantibody lysis, immunosuppressive dose of steroid such as Dexamethasone@2.2 mg/kg.b.wt could be used.

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Evaluation of buparvaquone (BUTA-Kel™ KELA, Belgium) as a treatment of East Coast fever in cattle, in the peri-urban of Dar Es Salaam city, Tanzania

Cited by 14 publications

References 6 publications

Identification of hard ticks (Acari: Ixodidae) and seroprevalence to Theileria parva in cattle raised in North Kivu Province, Democratic Republic of Congo

Identification of hard ticks (Acari: Ixodidae) and seroprevalence to Theileria parva in cattle raised in North Kivu Province, Democratic Republic of Congo

Buparvaquone

Bovine Tropical Theileriosis: An Update

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