Evaluation of C‐reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs

Severo, Julia So; Santana, Aline Elisa; Aoki, Valéria; Michalany, Nílceo Schwery; Mantovani, Matheus Matioli; Larsson, Carlos Eduardo

doi:10.1111/vde.12510

Cited by 9 publications

(11 citation statements)

References 28 publications

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“…Similarly, Severo et al showed that CRP is a useful inflammatory marker in dogs with pemphigus foliaceus. In our study, we evaluated PTX3, which is a similar inflammatory marker to CRP, and we consider that PTX3 is a more specific marker for PV than CRP since PTX3 is expressed by three different cells and is increased in the setting of local inflammation alone, as compared to CRP, which is produced by the liver alone and is increased in the settings of numerous systemic diseases [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

The role of pentraxin 3 in pemphigus vulgaris

Yavuz

2020

pdia

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Introduction: Pemphigus is a group of autoimmune bullous diseases caused by antibodies directed against the desmosomal adhesion molecules desmoglein 1 and 3, which are required for intercellular adhesion of keratinocytes. Pentraxins are a group of proteins that function as pattern recognition molecules and also play a role in humoral innate immunity. Pentraxin 3 (PTX3) is the prototype of the long pentraxins and has been shown to be increased in numerous autoimmune diseases. Aim: To investigate whether PTX3 can be used as a marker of PV caused by autoimmunity and resulting in tissue injury. Material and methods: The study included 30 patients who presented to the University Medical School Dermatology Department and were diagnosed with PV based on clinical, histological, and immunological findings. The control group included 30 healthy individuals. Human PTX3 concentration was measured with a commercially available ELISA kit, using a double antibody sandwich enzyme-linked immunosorbent assay. Results: The 60 participants comprised 31 (52%) men and 29 (48%) women. The most common site of onset was mucosa + skin (n = 22; 73.3%) and a psychological pathology was present in 7 (23.3%) patients. Median PTX3 level was significantly higher in the PV group compared to the control group (p = 0.008). The ROC curve analysis indicated a significant area under curve (AUC) value for serum PTX3 level in the prediction of PV. Conclusions: PTX3 was found to be increased in PV and PTX3 could be a useful indicator of disease activity in PV.

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Section: Discussionmentioning

confidence: 99%

The role of pentraxin 3 in pemphigus vulgaris

Yavuz

2020

pdia

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“…C-reactive protein (CRP) is one of acute phase proteins and being a marker for several diseases (Christensen et al, 2015;Hillström et al, 2016;Bremer et al, 2017;Severo et al, 2018). When the inflammatory cells are activated by different inflammatory stimuli, the acute phase response is triggered and different cytokines are released from the inflammatory cell (Hillström et al, 2015;Gommeren et al, 2018).…”

Section: Research Articlementioning

confidence: 99%

The Effect of Routine Therapy Alone and Combined with Hyperbaric Oxygen Treatment on Prognostic Factors in Dogs with Acute Pancreatitis

IJu¹,

TienHuan²,

HseinChi³

et al. 2019

PVJ

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The aim of this study was to evaluate the effect of supportive treatment combined with hyperbaric oxygen (HBO) therapy in dogs with acute pancreatitis by prognostic factors. Dogs entering the trial were randomly assigned to receive only regular supportive therapy (control group) or combined hyperbaric oxygen therapy with symptomatic and supportive therapy (HBOT group). The regular supportive measurements consisted of intravenous fluid, analgesia, antibiotics, antiemetics, gastric acid suppression, nutritional management, and so on. If the patient had diabetes mellitus, hyperglycemia was controlled by insulin. The dogs of the HBOT group were conducted in hyperbaric animal chamber (PAHI-A, Pan-America Hyperbarics Inc., R.O.C.) and HBO therapy involved 90 min of 100% oxygen treatment at a pressure of 2.5 ATA, once to twice daily for a total of 3 to 5 sessions. There were significant findings regarding to specific canine pancreatic lipase immunoreactivity (Spec cPL) and C-reactive protein (CRP) in the survivors, but no significant differences were found in the non-survivors. The down trend of sequential CRP concentration was noticed in HBOT group. The level of creatinine may be as an important criterion when the patients with AP were first visit clinic. The prognostic factors such as CRP, Spec cPL had a good response to routine combined with HBOT in survivors group. Likewise, the level of Spec cPL was decreased significantly after treatment no matter routine or routine combined with HBOT in survivors group. HBOT combined with symptomatic and routine treatment might improve systemic inflammation probably in canine acute pancreatitis. In survivors group the creatinine levels was significant lower than that in non-survivors group. Therefore, the levels of creatinine can be as prognostic factor in dogs with acute pancreatitis.To Cite This Article: Ho IJ, Hsu TH, Wang HC, Chen KS and Lee WM, 2019. The effect of routine therapy alone and combined with hyperbaric oxygen treatment on prognostic factors in dogs with acute pancreatitis. Pak Vet J, 39(4): 505-510. http://dx.

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“…8,19 In veterinary dermatology, the CRP serum level recently was found a valid disease severity biomarker for canine pemphigus foliaceus. 15 To date, there is only one publication that reports a useful biomarker for canine AD. 2 In this paper, a specific ELISA was developed for the canine S100A8 (calgranulin A, one of the two calprotectin subunits), and serum levels of S100A8 rose with increasing levels of AD severity in 213 atopic dogs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Plasma C-Reactive Protein as a Biomarker in Dogs with Atopic Dermatitis Receiving Allergen-Specific Immunotherapy: A Pilot Study

Favrot¹,

Fischer²,

Rostaher³

et al. 2021

SAT

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In this pilot study, we wished to determine if C-reactive protein (CRP) levels could be a useful severity or treatment biomarker for canine atopic dermatitis (AD). Nine atopic dogs received allergen immunotherapy for 1 year. Blood was collected before and at four re-evaluation visits. At each time point, the skin lesions were graded with the Canine Atopic Dermatitis Extent and Severity Index (CADESI) 4, and the plasma CRP levels were measured by Enzyme-linked Immunosorbent Assay (ELISA). We found a significant yet minimal correlation between the CRP levels and the CADESI4 scores. The CRP levels were not significantly different between dogs with AD of increasing severity. Finally, there was no correlation between the percentage change in CADESI4 and CRP values during immunotherapy. In conclusion, the lack of significant difference in CRP levels between dogs of increasing AD severity and lack of correlation between percentage changes in skin lesion and CRP values suggest that this protein would not be a clinically-useful biomarker in atopic dogs.

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Evaluation of C‐reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs

Abstract: CRP levels are increased in dogs with PF and exceed levels found in most dogs with SP.

Cited by 9 publications

References 28 publications

The role of pentraxin 3 in pemphigus vulgaris

The role of pentraxin 3 in pemphigus vulgaris

The Effect of Routine Therapy Alone and Combined with Hyperbaric Oxygen Treatment on Prognostic Factors in Dogs with Acute Pancreatitis

Evaluation of Plasma C-Reactive Protein as a Biomarker in Dogs with Atopic Dermatitis Receiving Allergen-Specific Immunotherapy: A Pilot Study

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Evaluation of C‐reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs

Abstract: CRP levels are increased in dogs with PF and exceed levels found in most dogs with SP.

Cited by 9 publications

References 28 publications

The role of pentraxin 3 in pemphigus vulgaris

The role of pentraxin 3 in pemphigus vulgaris

The Effect of Routine Therapy Alone and Combined with Hyperbaric Oxygen Treatment on Prognostic Factors in Dogs with Acute Pancreatitis

Evaluation of Plasma C-Reactive Protein as a Biomarker in Dogs with Atopic ­Dermatitis Receiving Allergen-Specific Immunotherapy: A Pilot Study

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Evaluation of Plasma C-Reactive Protein as a Biomarker in Dogs with Atopic Dermatitis Receiving Allergen-Specific Immunotherapy: A Pilot Study