Evaluation of camel milk: gross composition—a scientific overview

Benmeziane–Derradji, Farida

doi:10.1007/s11250-021-02689-0

Cited by 45 publications

(36 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Milk protein content is characterized by 2 major fractions, caseins and whey proteins, which represent 75 to 80% and 20 to 25% of total milk proteins, respectively (Farah, 1993;Konuspayeva et al, 2009;Al haj and Al Kanhal, 2010;Benmeziane-Derradji, 2021). The whey protein fraction is principally composed of several bioactive proteins, including immunoglobulins, β-lactoglobulin, α-lactalbumin, lactoperoxidase, lysozyme, lactophorin, and lactoferrin, with various nutri-tional and medicinal benefits (Krissansen, 2007;Badr et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Camel and bovine milk lactoferrins activate insulin receptor and its related AKT and ERK1/2 pathways

Khan

Anwar²,

Redwan³

et al. 2022

Journal of Dairy Science

View full text Add to dashboard Cite

Lactoferrin (LF) is a milk protein that may be an interesting candidate for the antidiabetic properties of milk due to its well-documented bioactivity and implication in diabetes. Here, we investigated the functional action of LF purified from camel and bovine milk (cLF, bLF) on insulin receptors (IR) and their pharmacology and signaling in hepatocarcinoma (HepG2) and human embryonic kidney (HEK293) cells. For this, we examined IR activation by bioluminescence resonance energy transfer (BRET) technology and the phosphorylation of its key downstream signaling kinases by western blot. The purified cLF and bLF induced phosphorylation of IR, AKT, and ERK1/2 in HepG2 and HEK293 cells. The BRET assays in HEK293 cells confirm the pharmacological action of cLF and bLF on IR, with a possible allosteric mode of action. This reveals for the first time the bioactivity of LF toward IR function, indicating it as a potential bioactive protein behind the antidiabetic properties of camel milk.

show abstract

Section: Introductionmentioning

confidence: 99%

Camel and bovine milk lactoferrins activate insulin receptor and its related AKT and ERK1/2 pathways

Khan

Anwar²,

Redwan³

et al. 2022

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that the milk yield from Bactrian camels is higher than that of single‐humped camels. The vitamin C content of camel milk (3.45 mg 100/g) is 3–5 times higher than that of cow milk (1.25 mg 100/g) (Benmeziane‐Derradji 2021). Furthermore, Bactrian camel milk is richer in Zn, Se, K, Ca, Na, Mg, Fe, Cu and other mineral elements than cow milk, and camel milk lacks β‐lactoglobulin but is rich in β‐casein and α‐lactalbumin, making it very similar to human milk (El‐Hatmi et al .…”

Section: Introductionmentioning

confidence: 93%

Quality characteristics and nutrient contents of Bactrian camel milk as determined by mid‐infrared spectroscopy

Li,

Liu,

Fan

et al. 2024

Int J of Dairy Tech

View full text Add to dashboard Cite

Reference methods for determining the contents of functional traits in camel milk are expensive and complex, hindering their widespread use. Mid‐infrared technology has the advantages of fast, economic, batch processing for dairy detection. In the present study, mid‐infrared spectroscopy (MIRS) prediction models previously established based on cow milk were used to predict 1101 Bactrian camel milk samples in terms of fat, protein, lactose, total solids, total casein, β‐casein, K, Ca, Na and Mg contents. The MIRS‐predicted values for the 10 traits were close to the reference values, demonstrating the utility and efficiency of the proposed method. Furthermore, the quality characteristics of camel milk were compared with those of other dairy animals, confirming that it is a valuable and rich source of essential nutrients for humans.

show abstract

“…Camel milk (CM) has been reported to have many interesting dietetic, medicinal, and social benefits. This was shown to be linked to its chemical and molecular composition and properties as documented by many analytical studies (1)(2)(3)(4)(5). Thus, it is now accepted that CM has beneficial effects in human health with potential applications in various diseases and disorders including diabetes, cancer, inflammation, hypertension, infection (6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Camel Milk Targeting Insulin Receptor—Toward Understanding the Antidiabetic Effects of Camel Milk

et al. 2022

View full text Add to dashboard Cite

Camel milk (CM) is known for its beneficial virtues in the human diet and health. This includes its antidiabetic properties demonstrated in many in vitro and in vivo studies. Nevertheless, the scientific rationale behind the molecular and cellular basis of such beneficial effects and the exact antidiabetic agent(s)/mechanism(s) are still elusive. In this review, we focused on the recent advances supporting the targeting of insulin receptor (IR) by CM components. Indeed, our recent work reported that CM proteins and derived peptides pharmacologically target IR in vitro leading to its activation and potentiation of insulin-mediated responses. The review describes the experimental approaches used to investigate the effects of CM on IR in vitro based on the fractionation of CM whey proteins to purify functional proteins and their hydrolysis by gastric proteases to generate bioactive peptides. In addition, we illustrated our cellular and molecular model consisting of studying the functional activity of CM fractions on IR and its downstream signaling pathways in the hepatocarcinoma (HepG2) and the human embryonic kidney (HEK293) cells using the bioluminescence resonance energy transfer (BRET), phosphorylation, and glucose uptake assays. Overall, our work demonstrated for the first time that CM lactoferrin and CM-derived bioactive peptides positively modulate IR and its related signaling pathways in HepG2 and HEK293 cells. As a conclusion, the pharmacological targeting of IR by CM sheds more light on the antidiabetic properties of CM by providing its molecular basis that may constitute a solid rationale for the development of new generation of antidiabetic tools from CM-derived proteins and peptides and the utilization of CM in the management of diabetes. The sequencing and the synthesis of the potent bioactive CM peptides may open promising perspectives for their application as antidiabetic agents.

show abstract

Evaluation of camel milk: gross composition—a scientific overview

Cited by 45 publications

References 74 publications

Camel and bovine milk lactoferrins activate insulin receptor and its related AKT and ERK1/2 pathways

Camel and bovine milk lactoferrins activate insulin receptor and its related AKT and ERK1/2 pathways

Quality characteristics and nutrient contents of Bactrian camel milk as determined by mid‐infrared spectroscopy

Camel Milk Targeting Insulin Receptor—Toward Understanding the Antidiabetic Effects of Camel Milk

Contact Info

Product

Resources

About