Evaluation of carcinogenicity and chronic toxicity associated with orthopedic implants in mice

Takamura, Kei; Hayashi, Kazuo; Ishinishi, Noburu; Yamada, Teruki; Sugioka, Yôichi

doi:10.1002/jbm.820280508

Cited by 120 publications

(56 citation statements)

References 31 publications

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“…These metallic ions pose a potential health hazard capable of inducing allergic reactions or even promoting the onset of cancer. [17][18][19] Several researches had previously investigated the selective leaching behaviour of TiNi and TiNiCu SMAs [20][21][22][23] ; however, the selective leaching of Ti, Ni, and Fe ions released from TiNiFe SMAs has not been studied. Therefore, this study investigated the selective leaching and surface properties of Ti 50 Ni 50-x Fe x (x = 1, 2, and 3) SMAs using inductively coupled plasma mass spectrometry (ICP-MS), an X-ray diffraction (XRD) analysis, electrochemical tests, and X-ray photoelectron spectroscopy (XPS).…”

Section: Introductionmentioning

confidence: 99%

Selective leaching and surface properties of TiNiFe shape-memory alloys

Chang¹,

Liou²,

Huang³

2017

Mater. tehnol.

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This study investigated the selective leaching and surface characteristics of Ti50Ni50-xFex (x = 1, 2, and 3) shape-memory alloys using inductively coupled plasma-mass spectrometry, X-ray diffractometry, electrochemical tests and X-ray photoelectron spectroscopy. According to our results, the concentrations of Ni and Fe ions selectively leached from each specimen were considerably higher than that of Ti ions. Electrochemical tests revealed a gradual deterioration in the corrosion resistance of the Ti50Ni50-xFex SMAs as the Fe content in the alloys was increased. X-ray photoelectron-spectroscopy results indicate that the surface of each specimen is primarily made up of a passive TiO2 film. NiO and Fe2O3 oxides, which also formed on the surfaces of the Ti50Ni50-xFex SMAs, caused a deterioration of the uniformity, undermining the protective effect of the TiO2 films, resulting in a highly selective leaching of the Ni and Fe ions. The Ti50Ni50-xFex SMAs exhibit a number of favourable properties compared to the other SMAs; however, high concentrations of selectively leached Ni and Fe ions may pose a risk in biomedical applications, particularly when used as implant materials. Keywords: TiNiFe shape-memory alloys, biomaterials, selective leaching, corrosion, X-ray photoelectron spectroscopy V {tudiji je prou~evano selektivno izpiranje in zna~ilnosti povr{ine zlitine s spominom Ti50Ni50-xFex (x = 1, 2, in 3), z uporabo masne spektrometrije z induktivno sklopljeno plazmo, rentgensko difrakcijo, elektrokemijskimi preizkusi in rentgensko fotoelektronsko spektroskopijo. Rezultati ka`ejo, da je bila koncentracija selektivno izpranih Ni in Fe ionov iz vsakega vzorca veliko ve~ja kot pa Ti ionov. Elektrokemijski preizkusi so pokazali postopno zmanj{anje korozijske odpornosti Ti50Ni50-xFex SMA, ko je vsebvnost Fe v zlitinah nara{~ala. Rezultati rentgenske fotoelektronske spektroskopije ka`ejo, da je povr{ina vseh vzorcev predvsem sestavljena iz pasivnih TiO2 plasti. NiO in Fe2O3 oksidi, ki so tudi nastali na povr{ini Ti50Ni50-xFex SMAs, poslab{ajo enotnost in ogro`ajo varovalno plast iz TiO2 prevlek, kar ima za posledico bolj selektivno izpiranje ionov Ni in Fe. Ti50Ni50-xFex SMAs vsebuje {tevilne ugodne lastnosti v primerjavi z drugimi SMA; vendar pa velika koncentracija selektivno izpranih Ni in Fe ionov lahko predstavlja tveganje pri biomedicinski uporabi, posebno pri implantiranih materialih. Klju~ne besede: TiNiFe zlitine s spominom, biomateriali, selektivno izpiranje, korozija, rentgenska fotoelektronska spektroskopija

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Section: Introductionmentioning

confidence: 99%

Selective leaching and surface properties of TiNiFe shape-memory alloys

Chang¹,

Liou²,

Huang³

2017

Mater. tehnol.

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“…Indeed, the fact that Ti-Ni contains approximately 50% nickel, which is considered a toxic and even carcinogenic element, represents the strongest argument against its use as an implant material because of a possible release of nickel in the human body and the potential danger to a patient's overall health [3].…”

Section: Introductionmentioning

confidence: 99%

Bulk and porous metastable beta Ti–Nb–Zr(Ta) alloys for biomedical applications

Braïlovski

Прокошкин

Gauthier

et al. 2011

Materials Science and Engineering: C

188

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Bulk and porous metastable beta Ti-Nb-Zr(Ta) alloys for biomedical applications Brailovski, V.; Prokoshkin, S.; Gauthier, M.; Inaekyan, K.; Dubinskiy, S.; Petrzhik, M.; Filonov, M.Contact us / Contactez nous: nparc.cisti@nrc-cnrc.gc.ca. In this work, metastable beta Ti-Nb-Zr(Ta) ingots were manufactured by vacuum arc melting. The ingots thus obtained were divided into two batches: the first subjected to cold rolling (CR) from 30 to 85% of thickness reduction and subsequent annealing in the 450 to 900°C temperature region, and the second atomized to produce 100 μm size powders. This powder was used to manufacture open-cell porous material. Regardless of the CR intensity, Ti-(18…20)Nb-(5…6)Zr (at.%) samples subjected to 600°C (1 h) annealing showed a significant material softening due to the stress-induced martensitic transformation. The Young's modulus of these alloys varied between 45 and 55 GPa, and the yield stress, between 300 and 500 MPa. The obtained Young's moduli, which are comparable to 55-66 GPa of concurrent beta-titanium alloys and 45-50 GPa of superelastic Ti-Ni alloys, come close to those of cortical bones. Compression testing of the porous material as a function of porosity (from~45 to 66%) and interconnected cell size (d 50 from 300 to 760 μm) showed the following properties: Young's modulus from 7.5 to 3.7 GPa, which comes close to that of trabecular bones, and ultimate compression strength, of from 225 to 70 MPa.

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“…It was observed that the replacement of metal by zirconia did not produce noticeable changes in the cellular response to the inserts. Previous work has shown the safety, biocompatibility and stability of zirconia ceramics (17)(18)(19), and the lack of mutagenic and carcinogenic effect (20).…”

Section: Discussionmentioning

confidence: 99%

Clinical and histopathological analysis of intramucosal zirconia inserts used for improving maxillary denture retention

et al. 2009

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Intramucosal inserts made of zirconia ceramic have been used for the rehabilitation of edentulous patients. This study aimed to follow up on patients with complete dentures having intramucosal zirconia inserts and to perform a histological analysis of biopsies of the epithelium surrounding the inserts. Twelve 31-66-year-old subjects of both genders received complete denture treatment having the intramucosal inserts in place. Detailed clinical, prosthetic and surgical procedures were described. Clinical exams were done on postoperative days 3, 7, 15, 120 and 360. One year after denture placement, the subjects received local anesthesia and the tissues surrounding the insertion sites in the alveolar ridge were removed using a scalpel blade. Biopsies were fixed for up to 48 h in 10% phosphate-buffered formaldehyde and 5-µm-thick sections were cut and stained with hematoxylin and eosin and Gomori Trichrome. Immunohistochemistry was used to identify endothelium (anti-CD3) and T lymphocytes (anti-CD31). Removing and reinserting the denture was painful until day 15, but all patients reported a marked increase in the retention and stability of the complete denture with little or no discomfort after 30 days. The histopathological analysis showed that zirconia inserts were well tolerated by the oral mucosa, with the presence of collagen fibers in the tissue around the insert, with mild inflammatory response and allowing reepithelialization, expressed by parakeratosis, epithelial hyperplasia and presenting granular layer. In conclusion, intramucosal zirconia inserts did not affect the health of oral mucosa and provide adequate retention and stability of the complete denture and comfort to the patients.

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Evaluation of carcinogenicity and chronic toxicity associated with orthopedic implants in mice

Cited by 120 publications

References 31 publications

Selective leaching and surface properties of TiNiFe shape-memory alloys

Selective leaching and surface properties of TiNiFe shape-memory alloys

Bulk and porous metastable beta Ti–Nb–Zr(Ta) alloys for biomedical applications

Clinical and histopathological analysis of intramucosal zirconia inserts used for improving maxillary denture retention

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