Evaluation of cardiac function based on ventricular pressure-volume relationships during assistance with a rotary blood pump

Ogawa, Daisuke; Abe, Kenichi; Olegario, P.; Kasahara, Koichiro; Shiraishi, Yasuyuki; Sekine, Keitaro; Yambe, Tomoyuki; Nitta, S.; Yoshizawa, Makoto

doi:10.1109/iembs.2006.4398669

Cited by 2 publications

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“…E max is considered the most reliable index for assessing myocardial contractility in the intact circulation and is almost insensitive to changes in preload and afterload (6). Further, it is an important cardiac function index for the detection of the recovery of assisted hearts with no need for pump stop, because it can detect cardiac function independently of the assistance level (4). In contrast, the EF, which is commonly used during the off‐pump test, cannot be applied without stopping the pump due to its sensitivity to the afterload, which depends on the pump model and rotational speed.…”

Section: Discussionmentioning

confidence: 99%

“…The data with the pump stopped was recorded during manual clamp of the aorta, which changed the ventricular afterload. This data was used for the estimation of E max using the multiple‐beats method, approximating the E max to the end‐systolic elastance ( E ES ), which corresponds to the slope of the end systolic pressure volume relationship (ESPVR) (2–4). The other data were used for the estimation of E max using the POM, a method in which the E max is estimated at each cardiac cycle independent of changes in the ventricular load.…”

Section: Methodsmentioning

confidence: 99%

“…The main objective of this study was to evaluate the validity of cardiac function indices during the assistance with RBPs. In particular, we choose the E max to be analyzed as it represents the ventricular contractility independently of the load (2–4), which was expected to compensate for the changes brought by different assistance conditions. In order to avoid sudden and unsuitable changes of the ventricular load that are required for the conventional multiple‐beats estimation method, we present an evaluation for the estimation of E max using the parameter optimization method (POM), a single beat estimation method (5).…”

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Estimation of Maximum Ventricular Elastance Under Assistance With a Rotary Blood Pump

et al. 2010

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The maximum ventricular elastance is a reliable index for assessing the cardiac function from changes in its pressure-volume relationship. The advantage of this index is that it can represent the contractility of either unassisted hearts or native hearts assisted with rotary blood pumps. However, there are situations in which changes in the ventricular load required for the conventional estimation method might be risky. For example, in a bridge-to-recovery the cardiac function should also be continuously observed after the implantation of a rotary blood pump. In this article, we present the results of the estimation of the maximum elastance with in vivo data using the parameter optimization method, which is a single-beat estimation method. The estimated values for the normal cardiac function (6.8 +/- 0.6, 4.5 +/- 0.9, 4.2 +/- 1.8 mm Hg/mL) were significantly different from those for the low cardiac function (3.2 +/- 1.5, 1.9 +/- 1.0, 1.9 +/- 1.2 mm Hg/mL) from the data of the three animals that were analyzed. Besides, the maximum elastance values were independent of the pump rotational speed. These results indicate that this index might be useful for the detection of the myocardial recovery.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Estimation of Maximum Ventricular Elastance Under Assistance With a Rotary Blood Pump

et al. 2010

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“…This may be due to insufficient depression of cardiac function to see the acute effect of LVAD support on effective systolic function. In addition, the range of LVAD speed in their study may not be wide enough to observe any change in global cardiac performance of the coupled system (20).…”

Section: Discussionmentioning

confidence: 98%

Ventricular Contractility and Compliance Measured During Axial Flow Blood Pump Support: In Vitro Study

Jhun

Cysyk

2013

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End-systolic elastance and end-diastolic compliance have been used to quantify systolic and diastolic function of the left ventricle (LV). In this study, the effective end-systolic elastance, (EES )eff , end-systolic volume intercept, (V0 )eff , and end-diastolic compliance of the LV were assessed at various levels of left ventricular assist device (LVAD) support. We tested the hypothesis that (EES )eff and (V0 )eff vary as a function of LVAD speed, while compliance does not change. The Penn State in vitro cardiac simulator was used in two heart conditions (control and heart failure [HF]) with the HeartMate II axial flow LVAD. The LVAD speed was linearly increased from 6000 to 11 000 rpm, with 500-rpm increments. The end-systolic and end-diastolic pressure-volume relationships were estimated at each LVAD speed. Acute LVAD support itself showed pseudo-improvement of ventricular contractility. The (EES )eff and (V0 )eff in HF were found to be dependent on the LVAD speed. The effective compliance for both control and HF was independent of the LVAD speed. Therefore, when examining the time-course cardiac recovery induced by the LVAD support, LV performance should be measured immediately before and after LVAD support while keeping LVAD speed consistent to avoid potential overestimation of long-term cardiac recovery.

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Evaluation of cardiac function based on ventricular pressure-volume relationships during assistance with a rotary blood pump

Cited by 2 publications

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Estimation of Maximum Ventricular Elastance Under Assistance With a Rotary Blood Pump

Estimation of Maximum Ventricular Elastance Under Assistance With a Rotary Blood Pump

Ventricular Contractility and Compliance Measured During Axial Flow Blood Pump Support: In Vitro Study

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