Evaluation of cardiac sphericity index among intrauterine growth restriction and normal fetuses

Borna, Sedigheh; Khanjany, Somayeh; Hantoushzade, Sedigheh; Khazardoost, Soghra; Mirzaeian, Sara; Ariana, Shideh; Hashemnezhad, Maryam

doi:10.1080/01443615.2021.1945005

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…The sensitivity and specificity of MPI for prediction of bad consequences in these two groups were 60% and 80%, and 65% and 70%, respectively [ 25 ]. The increased MPI is also associated with intrauterine hypoxia which leads to redistribution of blood circulation in FGR [ 26 ], and cerebral vasodilation further lead to abnormal left and right ventricular cardiac blood flow output, which exacerbates cardiac abnormalities in FGR [ 27 ]. Ductus venosus is not only the main distributor of fetal oxygenated blood flow, but also the direct channel between peripheral vein and central venous system.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Prediction of Fetal Growth Restriction and Postnatal Outcomes by Ultrasound Assessment of Fetal Myocardial Performance Index and Blood Flow Spectrum

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Fetal growth restriction (FGR) affects 5% to 10% of newborns and is a major determinant of perinatal morbidity and mortality. Myocardial performance index (MPI), also known as the Tei index, is a useful, noninvasive, and Doppler-derived myocardial performance tool for fetal cardiac function evaluation. The purpose of the study is to evaluate ultrasonic prediction on FGR and postnatal outcomes using MPI and blood flow spectrum. Methods. This retrospective study included 240 pregnant women developing FGR and 240 healthy pregnant women. The blood flow spectrum of middle cerebral artery (MCA), umbilical artery (UA), and ductus venous including systolic to diastolic ratio (S/D), resistant index (RI), pulse index (PI), and peak ventricular systolic velocity/atrial contraction valley velocity (S/a) were examined using the GE Voluson E8 ultrasound system. Results. The MPI, S/D, RI, PI of UA, and S/a were all higher but S/D, RI, and PI of MCA were lower in the FGR group than those in the control group P < 0.001 . The MPI, S/D, RI, PI of UA, S/D, RI, PI of MCA, and ductus venous S/a yielded AUC of 0.813, 0.835, 0.791, 0.804, 0.789, 0.796, 0.803, and 0.784 when they were used to predict the incidence of FGR. Of note, the pregnant women with poor pregnancy outcomes exhibited higher values of MPI, S/D, RI, PI of UA, and S/a with lower scores of 1 min Apgar concomitant with lower values regarding S/D, RI, and PI of MCA than those with favorable pregnancy outcomes P < 0.001 . The MPI (r = −0.623), S/D (r = −0.660), RI (r = −0.601), PI (r = −630) of UA, and S/a (r = −0.573) shared negative correlations with 1 min Apgar scores P < 0.001 . Of note, the S/D (r = 0.562), RI (r = 0.597), and PI (r = 0.619) of MCA were positively correlated with 1 min Apgar scores P < 0.001 . It was revealed that the MPI, S/D, RI, PI of UA, S/D, RI, PI of MCA, and ductus venous S/a yielded AUC of 0.806, 0.833, 0.774, 0.788, 0.807, 0.729, 0.748, and 0.770 when they were used to predict the incidence of poor pregnancy outcomes for pregnant women developing FGR. Conclusion. Our study demonstrates good ultrasonic prediction on FGR and postnatal outcomes using MPI and blood flow spectrum.

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Section: Discussionmentioning

confidence: 99%

Prenatal Prediction of Fetal Growth Restriction and Postnatal Outcomes by Ultrasound Assessment of Fetal Myocardial Performance Index and Blood Flow Spectrum

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Various indices, such as sphericity index, volumetric sphericity index, and eccentricity index, are commonly used to assess global left ventricular deformation, 3,4 which are inadequate for evaluating regional left ventricular morphology.…”

Section: Introductionmentioning

confidence: 99%

Apical morphology and dynamics analysis in hypertension and apical hypertrophic cardiomyopathy: new insights on the role of echocardiography

Lin,

Huang,

Ruan

et al. 2024

Preprint

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Background: The objective of this study was to introduce several novel indices to evaluate the apical morphological and dynamical features of apical hypertrophic cardiomyopathy (AHCM) and hypertensive patients using echocardiography. Methods: A total of 125 selected subjects underwent echocardiography imaging, 35 patients with AHCM, 45 patients with essential hypertension and 45 healthy controls. The apical morphological and dynamic features included apical-basal wall thickness ratio (ABR, maximal apical wall thickness / posterior basal wall thickness), apical angle (apA), peak blood flow velocity at the apical cavity (Vap) and its ratio to the velocity at left ventricular outflow tract (Vap/ Vlvot), and, relative apical longitudinal strain [RALS, RALS = apical longitudinal strain (LSapical)/ sum of basal and mid LS (LSbasal +LSmiddle)]. Results: Patients with hypertension had lower apA, higher Vap compared to healthy controls (p < 0.001 for all). However, ABR, Vap/ Vlvot, RALS between the 2 groups showed no statistically difference. Compared to healthy controls and hypertensives, AHCM had significantly higher ABR, Vap/ Vlvot, and lower apA, RALS (p < 0.001 for all). Conclusion: Echocardiography is a valuable and promising tool to assess the apical morphology and dynamics. ABR, apA, Vap/ Vlvot, RALS arrived from echocardiography can be used to distinguish between hypertension and AHCM.

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Comparison of cardiac morphology and function in small for gestational age fetuses and fetuses with late-onset fetal growth retardation

Turgut

Özdemir

Turan

et al. 2021

Journal of Perinatal Medicine

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Objectives To compare cardiac structural and functional findings of fetuses with fetal growth restriction (FGR) and small for gestational age (SGA). Methods In this prospective cohort study, patients were classified into three groups using Delphi procedure according to fetal weight, umbilical, uterine artery Doppler and cerebroplacental ratio. Fetal cardiac ultrasonographic morphology and Doppler examination was performed to all pregnant women at 36 weeks of gestation. Results Seventy three patients were included in the study. There were one (6.7%) patient in the control group, 2 (13.3%) in the SGA group and 12 (80%) in the FGR group who needed neonatal intensive care unit (NICU) and NICU requirement was significantly higher in FGR fetuses (p<0.001). Left spherical index was found to be lower only among FGR fetuses (p=0.046). Left ventricular wall thickness was decreased and the right/left ventricular wall ratio was increased in FGR fetuses (p=0.006, p<0.001). Tricuspid/mitral valve ratio and mitral annular plane systolic excursion value was lower in FGR fetuses (p=0.034, p=0.024 respectively). Also, myocardial performance index was remarkably higher in FGR group (p=0.002). Conclusions We detected cardiac morphological changes in cases of both SGA and FGR—more pronounced in the FGR cases. Findings related to morphological changes on the left side in FGR cases were considered secondary to volume increase in FGR cases as an indicator of a brain-protective effect. In the FGR group, both systolic and diastolic dysfunctions were detected in the left heart.

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Evaluation of cardiac sphericity index among intrauterine growth restriction and normal fetuses

Cited by 4 publications

References 27 publications

Prenatal Prediction of Fetal Growth Restriction and Postnatal Outcomes by Ultrasound Assessment of Fetal Myocardial Performance Index and Blood Flow Spectrum

Prenatal Prediction of Fetal Growth Restriction and Postnatal Outcomes by Ultrasound Assessment of Fetal Myocardial Performance Index and Blood Flow Spectrum

Apical morphology and dynamics analysis in hypertension and apical hypertrophic cardiomyopathy: new insights on the role of echocardiography

Comparison of cardiac morphology and function in small for gestational age fetuses and fetuses with late-onset fetal growth retardation

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