Evaluation of Cardioprotective Effect of Cyperus Triceps( Cyperaceae) Against Isoproterenol Induced Myocardial Infarction in Albino Rats

Abstract

This study was conducted to evaluate the cardioprotective effect of Cyperus triceps against isoproterenol produced myocardial infarction. The extract of Cyperus triceps in the doses of 200 mg/kg and 400 mg/kg was administered orally for 21 days prior to isoproterenol administration to test their cardioprotective effect. Isoproterenol (85 mg/kg) was administered intraperitoneally on 20 th and 21 st days respectively to induce myocardial infarction. The parameters for evaluation of cardioprotective activity were the Biochemical estimations and Histopathology examination. In biochemical estimations, the cardiac parameters such as CK-MB, SGOT SGPT and Triglycerides were determined. The levels changed by isoproterenol were restored significantly by the administration of the both doses of test extract especially at higher dose. The results of this study shows that Cyperus triceps extract has significant cardioprotective effect against isoprenaline induced myocardial infarction.