AimsTo evaluate the prevalence of dental caries and the presence of fissure sealants on the first permanent molars (FPMs) among 6 to 9 years old primary school boys in Riyadh, Kingdom of Saudi Arabia.Materials and methodsThe carious status and the presence of fissure sealants on the FPMs were examined in 1844 schoolboys, aged 6-9 years (the first three grades), from 17 randomly selected primary schools in Riyadh city, Kingdom of Saudi Arabia.Chi-square test was used to assess the significance of differences in prevalence and proportions.ResultsA total of 5394 FPMs were assessed in the 1844 children. Eighty-three point five percent of children were caries free. Only 0.8% of the children had at least one fissure sealant applied. At tooth level, the decayed FPMs counted for 10.6%. There was obvious underuse of fissure sealants on the FPMs; 0.5% (n = 25). The caries prevalence in the mandibular FPMs (14.4%), was significantly higher than in the maxillary FPMs, 7.7% (p < 0.01). The proportion of carious FPMs increased with age of the children significantly (p < 0.01). There was no significant difference in the proportion of the presence of fissure sealants among the three different grade/age groups (p > 0.05).ConclusionCaries prevalence in the FPMs was moderate but serious amongst this cohort of young students. This was opposed with very low use of fissure sealants.Clinical significanceCareful examination of the first permanent molars among children is mandatory because of their high caries susceptibility. It is important to increase public and dental professionals’ awareness of the effectiveness of fissure sealants and encouraging more placement.How to cite this article: Aldossary MS, Alamri AA, Alshiha SA, Hattan MA, Alfraih YK, Alwayli HM. Prevalence of Dental Caries and Fissure Sealants in the First Permanent Molars among Male Children in Riyadh, Kingdom Saudi Arabia. Int J Clin Pediatr Dent., 2018;11(5):365-370.