Evaluation of carotid intima media thickness and hematologic inflammatory markers in patients with chronic spontaneous urticaria

Abstract

Introduction: Low grade inflammation is associated with chronic spontaneous urticaria (CSU) and atherosclerosis. There are little data on the relationship between urticarial inflammation and atherosclerosis. The neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) have recently been studied in many diseases as a biomarker of inflammation. Aim: To evaluate hematologic inflammatory parameters and subclinical atherosclerosis in CSU patients. Material and methods: C-reactive protein (CRP), NLR, PLR, MPV and carotid intima media thickness (CIMT) in CSU patients were compared with healthy controls. Thirty CSU patients and 30 healthy controls participated in the study. Results: Thirty CSU patients and 30 healthy controls participated in the study. 53.3% of the patient group were females, 46.7% were males and the mean age was 37.7 ±7.7. 53.3% of the healthy control group were females, 46.7% were males and the mean age was 37.1 ±7.2. Body mass index was 24.63 ±2.7 kg/m 2 in the patient group and 24.83 ±2.5 kg/m 2 in the control group. Left and right CIMT and CRP values were higher in CSU patients and high-density lipoproteins (HDL) values were lower in the CSU patients. There was a positive correlation between the right and left CIMT and urticaria activity severity 4 (UAS4), disease severity, and triglycerides in the patient group, also a negative correlation was found between the right and left CIMT and the HDL values. C-reactive protein was also correlated with UAS4 and disease severity. Conclusions: This is the first study to evaluate subclinical atherosclerosis in CSU patients. Chronic spontaneous urticaria may be associated with an increased atherosclerotic risk. Serum CRP concentration can also be used as an objective parameter to evaluate disease severity.

Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria

“…The latest research focuses on the role of CRP in urticaria and metabolic syndrome. Yaldiz and Asil [97] found that CRP levels and HDL levels are negatively correlated, so CU may increase the risk of atherosclerosis [97]. For CSU patients with poor effect of antihistamines, their plasma CRP levels are significantly increased [98], for patients treated with omalizumab, and CRP levels significantly decreased after 12 weeks of treatment and are closely associated to UASs [99].…”

Chronic Urticaria and its Relation with Atheroscelorsis

“…In this study, it might have been discovered that there is no statistically noteworthy Contrast the middle of two concentrated on gatherings as respects good CCA IMT (mm) Also exited CCA IMT (mm). This is as opposed for Yaldiz Furthermore Asil, [10], who discovered that good Also exited CIMT qualities were statistically fundamentally higher in the CSU aggregation Likewise contrasted with the solid control bunch.…”

“…42 A long time. This may be in understanding with Yaldiz Also Asil, [10] who led An investigation around cu patients for intend agdistis 37. 7 ± 7.…”

“…90(± 4. 82 SD), this will be as opposed for Yaldiz Also asil, [10] who selected constant urticaria patients with Normal UAS about 16. 87 ±4.…”

“…This examine uncovered likewise An statistically critical connection between UAS7 What's more CCA IMT (mm) for correct Furthermore cleared out. This bring about assention for An investigation completed by Yaldiz and Asil, [10] with Normal UAS. was 16.87 ±4.0.…”