Evaluation of Carotid Plaque Neovascularization in Patients With Coronary Heart Disease on Contrast‐Enhanced Ultrasonography

Qin, Chuan; Zhang, Li; Wang, Xinfang; Duan, Yanying; Ye, Zhou; Xie, Mingxing

doi:10.1002/jum.14410

Cited by 11 publications

(8 citation statements)

References 34 publications

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“…Fifteen randomly selected patients were assessed for interobserver and intraobserver variability of carotid IMR . To assess intraobserver variability, the same observer measured carotid IMR twice using the software system at an interval of 1 week.…”

Section: Methodsmentioning

confidence: 99%

“…Fifteen randomly selected patients were assessed for interobserver and intraobserver variability of carotid IMR. 9 To assess intraobserver variability, the same observer measured carotid IMR twice using the software system at an interval of 1 week. To assess interobserver variability, carotid IMR was performed by a second observer, who was blinded to the results of the first observer.…”

Section: Reproducibility Of Carotid Imrmentioning

confidence: 99%

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Carotid Intima–Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima‐Media Thickness

Xie

Zhang

et al. 2018

J of Ultrasound Medicine

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Objectives To investigate carotid intima‐media roughness (IMR) in hypertensive patients with normal carotid intima‐media thickness (IMT) using automatic identification software and the correlation between carotid IMR and risk factors. Methods This case‐control study comprised 61 hypertensive patients with normal carotid IMT and 51 control participants. Carotid IMR, carotid IMT, pulsed wave velocity (PWV), stiffness (β), and arterial compliance were determined by carotid ultrasound and image postprocessing using an automatic identification program and echo‐tracking analysis software. Results Carotid IMR, mean carotid IMT, maximum carotid IMT, β, and PWV in the hypertension group were higher than those in the control group (58.24 versus 34.61 μm, 641.17 versus 576.48 μm, 746.82 versus 640.55 μm, 9.42 versus 7.35, and 7.10 versus 5.86 m/s, respectively; P < .05), and arterial compliance was lower than that in the control group (0.70 versus 0.95 mm2/kPa; P < .05). Intima‐media roughness was correlated with maximum IMT, mean IMT, PWV, β, age, diagnosis of hypertension for greater than 1 year, and pulse pressure. Multivariate logistic regression showed that age, diagnosis of hypertension for greater than 1 year, and pulse pressure were influential factors for IMR in hypertensive patients, with odds ratios of 6.719 (95% confidence interval, 1.658–27.221; P = .008), 4.726 (95% confidence interval, 1.174–19.022; P = .029), and 3.998 (95% confidence interval, 1.033–15.466; P = .045), respectively. Conclusions Carotid IMR and the elasticity index have important clinical importance in evaluating the risk of early atherosclerosis in hypertensive populations.

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Section: Methodsmentioning

confidence: 99%

Section: Reproducibility Of Carotid Imrmentioning

confidence: 99%

Carotid Intima–Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima‐Media Thickness

Xie

Zhang

et al. 2018

J of Ultrasound Medicine

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“…Among them, 100 were further excluded due to different research designs or insufficient data. Finally, 10 papers were included in this metaanalysis [16][17][18][19][20][21][22][23][24][25]. Further information about the search process and inclusion and exclusion criteria was shown in Figure 1.…”

Section: Search Processmentioning

confidence: 99%

Diagnostic Performance of Atherosclerotic Carotid Plaque Neovascularization with Contrast-Enhanced Ultrasound: A Meta-Analysis

Dong

Hou

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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Objectives. To evaluate the diagnostic performance of contrast-enhanced ultrasound (CEUS) for atherosclerotic carotid plaque neovascularization. Methods. The electronic databases like PubMed, Embase, OVID, and Web of Science were used to search for the relevant studies, which are involved in the evaluation of the diagnostic parameters of QUS for atherosclerotic carotid plaque neovascularization. Review Manager 5.4 and Stata 14.0 were used to estimate the pooled diagnostic value of CEUS. Forest plots, sensitivity analysis, and Deeks’ funnel plots were performed on the included studies. Results. Ten studies eventually met the final inclusion criteria. For diagnostic performance, CUES showed that the pooled values of sensitivity, specificity, positive likelihood odds ratios, negative likelihood odds ratios, and diagnostic odds ratios were 0.83 (95% CI 0.78-0.86), 0.77 (95% CI 0.68-0.84), 3.61 (95% CI 2.59-5.03), 0.23 (95% CI 0.18-0.28), and 16.02 (95% CI 10.02-25.60), respectively. The estimate of the area under curve (AUC) was 0.85 (95% CI 0.82-0.88). Conclusion. Our research supported that CEUS had high sensitivity and specificity in the diagnosis of atherosclerotic carotid plaque neovascularization. More high-quality prospective multicenter studies focusing on the accuracy of CEUS for carotid atherosclerotic plaque should be performed to verify our conclusions.

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“…A carotid plaque was identified as an echoic focal wall thickening at least 50% greater than that of the surrounding vessel wall or focal region with carotid IMT greater than 1.5 mm and protruding into the lumen, distinct from the adjacent structures 29 . Carotid plaques were classified on the basis of echo features as follows: 30 (a) soft plaque, hypoechoic relatively to the adventitia, with no acoustic shadow (hypoechoic area > 80% of the plaque area); (b) hard plaque, isoechoic or hyperechoic relatively to the adventitia, with an acoustic shadow (hyperechoic area > 80% of the plaque area); (c) mixed plaque, no acoustic shadow, with a calcified area of less than 90% of the plaque area, and an anechoic zone of less than 80% of the plaque area 31 .…”

Section: Methodsmentioning

confidence: 99%

Predictive value of carotid artery ultrasonography for the risk of coronary artery disease

Zhu

You²,

et al. 2020

J of Clinical Ultrasound

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Purpose To assess carotid intima‐media thickness (IMT), carotid plaques, and cardiovascular risk factors in patients with suspected coronary artery disease (CHD) to determine their association and predictive value for CHD. Methods We performed duplex Doppler ultrasonography of the carotid arteries and coronary angiography or CT in 480 patients with suspected CHD, and investigated their personal and medical histories. Patients were then assigned to the CHD or the control group depending on the presence of coronary lesions. Ultrasonography was performed the morning after admission prior to any treatment, coronary angiography, or CT. Results Carotid plaques were mainly distributed in the common carotid artery bifurcation, with a significant difference between the CHD and control groups. Plaque incidence (80%) and IMT were significantly higher (P < .001 and P = .012, respectively) in the CHD (80% and 0.84 ± 0.21 mm) than in the control group (49% and 0.76 ± 0.18 mm). The factors significantly associated with CHD were introduced into a multivariate regression model. Male subject (OR = 1.569, 95%CI 1.004‐2.453; P = .048) and plaque burden (OR = 0.457, 95%CI 0.210‐0.993; P = .048) were significant predictors for CHD occurrence. The presence of carotid plaques performed significantly better than IMT and the Framingham risk score for predicting CHD lesions (P < .001 for both). Conclusions CHD patients showed higher percentage of clinical (plaques) or subclinical (IMT) carotid artery wall change, and the presence of carotid plaques showed better predictive value than IMT and Framingham risk score for the presence of coronary artery lesions.

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Evaluation of Carotid Plaque Neovascularization in Patients With Coronary Heart Disease on Contrast‐Enhanced Ultrasonography

Abstract: Carotid plaque enhancement is a potential independent risk factor for ACS occurrence. These results illustrate the correlation of carotid plaque vulnerability with the coronary artery symptomatic state according to the common pathogenetic mechanism of atherosclerosis.

Cited by 11 publications

References 34 publications

Carotid Intima–Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima‐Media Thickness

Carotid Intima–Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima‐Media Thickness

Diagnostic Performance of Atherosclerotic Carotid Plaque Neovascularization with Contrast-Enhanced Ultrasound: A Meta-Analysis

Predictive value of carotid artery ultrasonography for the risk of coronary artery disease

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