Evaluation of Cartilage Repair Tissue after Matrix-Associated Autologous Chondrocyte Transplantation Using a Hyaluronic-Based or a Collagen-Based Scaffold with Morphological MOCART Scoring and Biochemical T2 Mapping

Welsch, Goetz H.; Mamisch, Tallal C.; Žák, Lukáš; Blanke, Matthias; Olk, Alexander; Marlovits, Stefan; Trattnig, Siegfried

doi:10.1177/0363546509354971

Cited by 103 publications

(41 citation statements)

References 50 publications

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“…A recent study using MRI and the Brittberg score to compare cartilage repair by Hyalograft C and CaReS MACI techniques in 20 patients 2 years postoperatively showed comparable clinical outcome, but different repair tissue composition [65]. The preliminary experience with another MACI alternative, BioSeed-C, a bioresorbable 2-component gel-polymer scaffold embedded with autologous chondrocytes, has also been promising [66, 67].…”

Section: Resultsmentioning

confidence: 99%

Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques

Dewan

Gibson

Elisseeff

et al. 2014

BioMed Research International

117

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Articular cartilage defects have been addressed using microfracture, abrasion chondroplasty, or osteochondral grafting, but these strategies do not generate tissue that adequately recapitulates native cartilage. During the past 25 years, promising new strategies using assorted scaffolds and cell sources to induce chondrocyte expansion have emerged. We reviewed the evolution of autologous chondrocyte implantation and compared it to other cartilage repair techniques. Methods. We searched PubMed from 1949 to 2014 for the keywords “autologous chondrocyte implantation” (ACI) and “cartilage repair” in clinical trials, meta-analyses, and review articles. We analyzed these articles, their bibliographies, our experience, and cartilage regeneration textbooks. Results. Microfracture, abrasion chondroplasty, osteochondral grafting, ACI, and autologous matrix-induced chondrogenesis are distinguishable by cell source (including chondrocytes and stem cells) and associated scaffolds (natural or synthetic, hydrogels or membranes). ACI seems to be as good as, if not better than, microfracture for repairing large chondral defects in a young patient's knee as evaluated by multiple clinical indices and the quality of regenerated tissue. Conclusion. Although there is not enough evidence to determine the best repair technique, ACI is the most established cell-based treatment for full-thickness chondral defects in young patients.

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Section: Resultsmentioning

confidence: 99%

Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques

Dewan

Gibson

Elisseeff

et al. 2014

BioMed Research International

117

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“…For example, stable minor tears or degeneration of the TFCC, as well as repaired tissues, may be monitored longitudinally for signs of deterioration without obvious morphologic changes. Sensitivity of many quantitative MR techniques to composition of load-bearing musculoskeletal tissues [8, 21] is yet another reason for applying quantitative techniques in the wrist.…”

Section: Discussionmentioning

confidence: 99%

“…Quantitative techniques including T2 [6] and T1rho [7] mapping are able to discern biochemical composition [8] and biomechanical properties [9] of articular cartilage. Such techniques have proven sensitivity to cartilage degeneration in the knee, and are likely capable of detecting similar structural alterations in the fibrocartilaginous TFCC.…”

Section: Introductionmentioning

confidence: 99%

MR morphology of triangular fibrocartilage complex: correlation with quantitative MR and biomechanical properties

et al. 2015

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Objective To evaluate pathology of the triangular fibrocartilage complex (TFCC) using high resolution morphologic magnetic resonance (MR) imaging, and compare with quantitative MR and biomechanical properties. Materials and Methods Five cadaveric wrists (22 to 70 yrs) were imaged at 3T using morphologic (proton density weighted spin echo, PD FS, and 3D spoiled gradient echo, 3D SPGR) and quantitative MR sequences to determine T2 and T1rho properties. In eight geographic regions, morphology of TFC disc and laminae were evaluated for pathology and quantitative MR values. Samples were disarticulated and biomechanical indentation testing was performed on the distal surface of the TFC disc. Results On morphologic PD SE images, TFC disc pathology included degeneration and tears, while that of the laminae included degeneration, degeneration with superimposed tear, mucinous transformation, and globular calcification. Punctate calcifications were highly visible on 3D SPGR images and found only in pathologic regions. Disc pathology occurred more frequently in proximal regions of the disc than distal regions. Quantitative MR values were lowest in normal samples, and generally higher in pathologic regions. Biomechanical testing demonstrated an inverse relationship, with indentation modulus being high in normal regions with low MR values. The laminae studied were mostly pathologic, and additional normal samples are needed to discern quantitative changes. Conclusion These results show technical feasibility of morphologic MR, quantitative MR, and biomechanical techniques to characterize pathology of the TFCC. Quantitative MRI may be a suitable surrogate marker of soft tissue mechanical properties, and a useful adjunct to conventional morphologic MR techniques.

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“…Collagen scaffolds provide the foundation for autologous matrix-induced chondrogenesis, both cell-free [120,121,122] and cell-assisted [120,123]. Of particular interest is MACI aided by collagen [124,125,126], hyaluronic acid [127,128], or fibrin glue [129]. …”

Section: Tissue-engineered Constructsmentioning

confidence: 99%

Repair of Damaged Articular Cartilage: Current Approaches and Future Directions

Medvedeva

Grebenik

Gornostaeva

et al. 2018

IJMS

212

152

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Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage damaged in connection with osteoarthritis or trauma. Here, we discuss current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice. We also describe potential future directions in this area, including tissue engineering based on scaffolding and/or stem cells as well as a combination of gene and cell therapy. Particular focus is placed on cell-based approaches and the potential of recently characterized chondro-progenitors; progress with induced pluripotent stem cells is also discussed. In this context, we also consider the ability of different types of stem cell to restore hyaline cartilage and the importance of mimicking the environment in vivo during cell expansion and differentiation into mature chondrocytes.

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Evaluation of Cartilage Repair Tissue after Matrix-Associated Autologous Chondrocyte Transplantation Using a Hyaluronic-Based or a Collagen-Based Scaffold with Morphological MOCART Scoring and Biochemical T2 Mapping

Abstract: In the follow-up of cartilage repair procedures using matrix-associated autologous chondrocyte transplantation, differences due to scaffolds have to be taken into account.

Cited by 103 publications

References 50 publications

Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques

Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques

MR morphology of triangular fibrocartilage complex: correlation with quantitative MR and biomechanical properties

Repair of Damaged Articular Cartilage: Current Approaches and Future Directions

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