Evaluation of Carum-loaded Niosomes on Breast Cancer Cells:Physicochemical Properties, In Vitro Cytotoxicity, Flow Cytometric, DNA Fragmentation and Cell Migration Assay

Barani, Mahmood; Mirzaei, Mohammad; Torkzadeh‐Mahani, Masoud; Adeli-Sardou, Mahboubeh

doi:10.1038/s41598-019-43755-w

Cited by 109 publications

(45 citation statements)

References 45 publications

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“…Our results also indicate that the SP and NESP did not significantly alter the renal MDA contents (4.52 ± 0.22 and 4.0 ± 0.14 nmol/mg, respectively) compared to the control group (3.23 ± 0.35 nmol/mg) (p = 0.99, p = 0.94, respectively). Even though the SP decreased the MDA levels in the I/R group (6.11 ± 0.25 nmol/mg) compared to the untreated I/R group (8.42 ± 0.45 nmol/mg) (p < 0.05), there was still a significant difference in the MDA levels compared to the control group (3.23 ± 0.35 Regarding encapsulation efficiency as well as drug release of spironolactone (SP) into the microemulations, based on the similarities in the chemical structure of SP and another drugs studied by our group [41][42][43][44], it is expected that encapsulation efficiency of the microemulations can be above 80% and sustained release of SP will be about 50% after 24 h.…”

Section: In Vivo Studiesmentioning

confidence: 94%

“…Fitting a curve to the ACF yielded a decay rate from which the hydrodynamic diameter of SP-based microemulsions was measured to be approximately 6 nm based the diffusion data (3.83256 × 10 −11 m 2 /s) [38][39][40]. Regarding encapsulation efficiency as well as drug release of spironolactone (SP) into the microemulations, based on the similarities in the chemical structure of SP and another drugs studied by our group [41][42][43][44], it is expected that encapsulation efficiency of the microemulations can be above 80% and sustained release of SP will be about 50% after 24 h.…”

Section: Physical Characterization Of Oil-in-water Microemulsions Containing Spmentioning

confidence: 99%

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Oil-In-Water Microemulsion Encapsulation of Antagonist Drugs Prevents Renal Ischemia-Reperfusion Injury in Rats

et al. 2021

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Developing new therapeutic drugs to prevent ischemia/reperfusion (I/R)-induced renal injuries is highly pursued. Liposomal encapsulation of spironolactone (SP) as a mineralocorticoid antagonist increases dissolution rate, bioavailability and prevents the drug from degradation. In this context, this work develops a new formulation of oil-in-water type microemulsions to enhance the bioavailability of SP. The size of the SP-loaded microemulsion was about 6.0 nm by dynamic light scattering analysis. Briefly, we investigated the effects of nano-encapsulated SP (NESP) on renal oxidative stress, biochemical markers and histopathological changes in a rat model of renal I/R injury. Forty eight male Wistar rats were divided into six groups. Two groups served as control and injury model (I/R). Two groups received “conventional” SP administration (20 mg/kg) and NESP (20 mg/kg), respectively, for two days. The remaining two groups received SP (20 mg/kg) and NESP (20 mg/kg) two days before induction of I/R. At the end of the experiments, serum and kidneys of rats underwent biochemical, molecular and histological examinations. Our results showed that I/R induces renal oxidative stress, abnormal histological features and altered levels of renal biomarkers. Administration of SP in healthy animals did not cause any significant changes in the measured biochemical and histological parameters compared to the control group. However, SP administration in the I/R group caused some corrections in renal injury, although it could not completely restore I/R-induced renal oxidative stress and kidney damage. On the contrary, NESP administration restored kidney oxidative injury via decreasing renal lipid peroxidation and enhancing glutathione, superoxide dismutase and catalase in kidneys of the I/R group. The deviated serum levels of urea, creatinine, total proteins and uric acid were also normalized by NESP administration. Furthermore, NESP protected against renal abnormal histology features induced by I/R. Therefore, NESP has beneficial effects in preventing kidney damage and renal oxidative stress in a rat model of I/R, which deserves further evaluations in the future.

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Section: In Vivo Studiesmentioning

confidence: 94%

Section: Physical Characterization Of Oil-in-water Microemulsions Containing Spmentioning

confidence: 99%

Oil-In-Water Microemulsion Encapsulation of Antagonist Drugs Prevents Renal Ischemia-Reperfusion Injury in Rats

et al. 2021

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“…To overcome the limitations of conventional diagnostic methods for UTIs, a significant number of nanotechnology-based bioassays are highly effective [55][56][57][58][59][60]. One of these important techniques is optical imaging based on differences in contrast agents between different tissues.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Urinary Tract Infections

et al. 2021

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The diagnosis and treatment of urinary tract infections (UTIs) remain challenging due to the lack of convenient assessment techniques and to the resistance to conventional antimicrobial therapy, showing the need for novel approaches to address such problems. In this regard, nanotechnology has a strong potential for both the diagnosis and therapy of UTIs via controlled delivery of antimicrobials upon stable, effective and sustained drug release. On one side, nanoscience allowed the production of various nanomaterial-based evaluation tools as precise, effective, and rapid procedures for the identification of UTIs. On the other side, nanotechnology brought tremendous breakthroughs for the treatment of UTIs based on the use of metallic nanoparticles (NPs) for instance, owing to the antimicrobial properties of metals, or of surface-tailored nanocarriers, allowing to overcome multidrug-resistance and prevent biofilm formation via targeted drug delivery to desired sites of action and preventing the development of cytotoxic processes in healthy cells. The goal of the current study is therefore to present the newest developments for the diagnosis and treatment of UTIs based on nanotechnology procedures in relation to the currently available techniques.

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“…With this in mind, as a continuous effort related to the synthesis of nanomaterials and investigation of their potential in biological applications [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ], we currently review here different nanomaterials applied to diagnosis and treatment of inflammatory arthritis.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Hosseinikhah

Barani

Rahdar

et al. 2021

IJMS

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Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis (RA), the most common complex multifactorial joint-associated autoimmune inflammatory disorder. RA is characterized by an inflammation of the synovium with increased production of proinflammatory cytokines (IL-1, IL-6, IL-8, and IL-10) and by the destruction of the articular cartilage and bone, and it is associated with the development of cardiovascular disorders such as heart attack and stroke. While a number of imaging tools allow for the monitoring and diagnosis of inflammatory arthritis, and despite ongoing work to enhance their sensitivity and precision, the proper assessment of RA remains difficult particularly in the early stages of the disease. Our goal here is to describe the benefits of applying various nanomaterials as next-generation RA imaging and detection tools using contrast agents and nanosensors and as improved drug delivery systems for the effective treatment of the disease.

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Evaluation of Carum-loaded Niosomes on Breast Cancer Cells:Physicochemical Properties, In Vitro Cytotoxicity, Flow Cytometric, DNA Fragmentation and Cell Migration Assay

Cited by 109 publications

References 45 publications

Oil-In-Water Microemulsion Encapsulation of Antagonist Drugs Prevents Renal Ischemia-Reperfusion Injury in Rats

Oil-In-Water Microemulsion Encapsulation of Antagonist Drugs Prevents Renal Ischemia-Reperfusion Injury in Rats

Nanomaterials for the Diagnosis and Treatment of Urinary Tract Infections

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

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