Evaluation of Casein Phosphopeptide–Amorphous Calcium Phosphate Effect on the Bond Strength of Self-etch Adhesives to Dentin: A Systematic Review

Abstract

Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is used as a remineralizing agent, ultimately reducing dental caries. The systematic review was performed as a review on the evaluation of CPP-ACP effect on the bond strength of self-etch adhesives to dentin. Medline (via PubMed) and Google Scholar were among the databases that were searched. Articles written exclusively in English and released up until 30 November 2021, were included. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) criteria were followed in the conduct of this research. There were 479 published studies found in the search results. Thirteen studies were chosen following full-text analysis and the elimination of duplicate studies. Overall, the outcomes showed that CPP-ACP has positive impacts on the bond strength of self-etch adhesive to dentin. The search keywords were "CPP-ACP