Evaluation of cashew gum-polyvinyl alcohol (CG-PVA) electrospun nanofiber mat for scarless wound healing in a murine model

Rajora, Aditya Dev; Bal, Trishna

doi:10.1016/j.ijbiomac.2023.124417

Cited by 17 publications

(3 citation statements)

References 37 publications

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“…These results suggested that RPFM exhibited an improved thermal stability compared to their native PVA, which was in agreement with the previous report [71]. To support the present study, Rajora and Bal [72] found a similar weight loss of ~61% between 25 and 200 • C for PVA electrospun fibers and further reported that the PVA/cashew gum polysaccharide (CGP) fibers had a highest degradation (~48%) at 350 • C and complete degradation at 550 • C, demonstrating the improved thermal stability of PVA/CGP fibers in comparison to the native PVA fibers [72].…”

Section: Rpfm Thermogravimetric Analyses (Tga)supporting

confidence: 93%

Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications

Zamora-Ledezma,

Hernández,

López-González

et al. 2023

Polymers

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Nowadays, there exists a huge interest in producing innovative, high-performance, biofunctional, and cost-efficient electrospun biomaterials based on the association of biocompatible polymers with bioactive molecules. Such materials are well-known to be promising candidates for three-dimensional biomimetic systems for wound healing applications because they can mimic the native skin microenvironment; however, many open questions such as the interaction mechanism between the skin and the wound dressing material remain unclear. Recently, several biomolecules were intended for use in combination with poly(vinyl alcohol) (PVA) fiber mats to improve their biological response; nevertheless, retinol, an important biomolecule, has not been combined yet with PVA to produce tailored and biofunctional fiber mats. Based on the abovementioned concept, the present work reported the fabrication of retinol-loaded PVA electrospun fiber mats (RPFM) with a variable content of retinol (0 ≤ Ret ≤ 25 wt.%), and their physical–chemical and biological characterization. SEM results showed that fiber mats exhibited diameters distribution ranging from 150 to 225 nm and their mechanical properties were affected with the increasing of retinol concentrations. In addition, fiber mats were able to release up to 87% of the retinol depending on both the time and the initial content of retinol. The cell culture results using primary mesenchymal stem cell cultures proved the biocompatibility of RPFM as confirmed by their effects on cytotoxicity (low level) and proliferation (high rate) in a dose-dependent manner. Moreover, the wound healing assay suggested that the optimal RPFM with retinol content of 6.25 wt.% (RPFM-1) enhanced the cell migratory activity without altering its morphology. Accordingly, it is demonstrated that the fabricated RPFM with retinol content below the threshold 0 ≤ Ret ≤ 6.25 wt.% would be an appropriate system for skin regenerative application.

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Section: Rpfm Thermogravimetric Analyses (Tga)supporting

confidence: 93%

Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications

Zamora-Ledezma,

Hernández,

López-González

et al. 2023

Polymers

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“…It is produced from either the polymerization of vinyl acetate or the radical polymerization of vinyl formate, vinyl pivalate, and vinyl trifluoroacetate [90]. PVA has been extensively used as a polymeric matrix for the fabrication of polymers for skin and tissue repair, including hydrogels [91,92], membranes [93], xerogels [94], fibers [95,96], electrospun fiber mats [97], porous scaffolds, and 3D-printed scaffolds due to its biodegradable, hydrophilic, and biocompatible nature [98,99]. Its great potential in regenerative medicine lies in its low cytotoxicity, high water absorption, favorable mechanical properties, and biocompatibility.…”

Section: Poly(vinyl Alcohol) (Pvoh Pva or Pval)mentioning

confidence: 99%

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

Elango,

Zamora-Ledezma,

Maté-Sánchez de Val

2023

J. Compos. Sci.

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Modern research has evolved several approaches toward skin regeneration and one of the novel concerns is the use of polymer-based systems due to their excellent beneficial properties to the skin. Several polymers, such as cellulose, hyaluronan, alginate, chitosan, collagen, fibrin and fibroin, have been tested and have proven the benefits for skin regeneration, and most of them are derived from either polysaccharide- or protein-based materials. In order to understand the mode of action, several researchers investigated the cell–matrix interaction and possible signaling mechanism in skin regeneration. Not only the signaling mechanism but also the mode of cell communication determines the application of polysaccharide- and protein-based polymers in practice. Based on the above significance, this review disclosed the recent findings to compile a possible method of communication between cells and polymers derived from polysaccharide-based (such as cellulose, hyaluronan, chitosan, alginate, agar, and xanthan gum) and protein-based (such as collagen, gelatin, fibrin, and silk fibroin) materials along with other polymers, such as poly(vinyl alcohol), polyglycolide or poly(glycolic acid), or poly(lactic acid) in skin regeneration. Accordingly, this review addresses the fundamental concept of cell–matrix communication, which helps us to understand the basis of the polymer’s functions in the biomedical field.

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“…Vazquez-Gonzalez et al [26], in a recent study also carried out in our lab, reported the use of one of the mixtures of a similar cashew gum and high-molecular-weight PEO and also of other biopolymers, whose development process is presented in this paper, to encapsulate M. caribbica to fight fungal activity in avocado. Another recent study also assessed an electrospun blend of cashew gum and polyvinyl alcohol (CG-PVA) nanofibers, with an optimal ratio of 7:3, for scarless wound healing [27]. Andrade et al [10] studied the thermoplastic extrusion of cashew gum to determine the effect of this processing technique on this natural gum.…”

Section: Introductionmentioning

confidence: 99%

On the Unique Morphology and Elastic Properties of Multi-Jet Electrospun Cashew Gum-Based Fiber Mats

Grumi,

Prieto,

Furtado

et al. 2024

Polymers

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This study investigates the unique morphology and mechanical properties of multi-jet electrospun cashew gum (CG) when combined with high-molecular-weight polyethylene oxide (PEO) and glycerol. Cashew gum (CG) is a low-cost, non-toxic heteropolysaccharide derived from Anacardium occidentale trees. Initially, the electrospinnability of aqueous solutions of cashew gum alone or in combination with PEO was evaluated. It was found that cashew gum alone was not suitable for electrospinning; thus, adding a small quantity of PEO was needed to create the necessary molecular entanglements for fiber formation. By using a single emitter with a CG:PEO ratio of 85:15, straight and smooth fibers with some defects were obtained. However, additional purification of the cashew gum solution was needed to produce more stable and defect-free straight and smooth fibers. Additionally, the inclusion of glycerol as a plasticizer was required to overcome material fragility. Interestingly, when the optimized formulation was electrospun using multiple simultaneous emitters, thicker aligned fiber bundles were achieved. Furthermore, the resulting oriented fiber mats exhibited unexpectedly high elongation at break under ambient conditions. These findings underscore the potential of this bio-polysaccharide-based formulation for non-direct water contact applications that demand elastic properties.

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Evaluation of cashew gum-polyvinyl alcohol (CG-PVA) electrospun nanofiber mat for scarless wound healing in a murine model

Cited by 17 publications

References 37 publications

Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications

Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

On the Unique Morphology and Elastic Properties of Multi-Jet Electrospun Cashew Gum-Based Fiber Mats

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