Evaluation of Caspase-3 mRNA Gene Expression Activity in Amyloid Beta-induced Alzheimer’s Disease Rats

Kamelia, Emma; Isl, Andi Asadul; Hatta, Mochammad; Kaelan, Cahyono; Patellongi, Ilhamjaya; Mas, Muh Nasrum; Tammasse, Jumraini; Nasrullah, .; Hardjo, Marhaen; Bintang, Maria; Miko, Hadiyat

doi:10.3923/jms.2017.117.125

Cited by 6 publications

(3 citation statements)

References 55 publications

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“…In the current study, the up-regulation of the caspase-3 gene in group II indicated the apoptotic effects of IBO acid on rat's hippocampus tissues. The ndings of Kamelia et al (Kamelia et al 2017) indicated that the accumulation of amyloid-beta exhibited overexpression of caspase-3.…”

Section: )mentioning

confidence: 97%

RETRACTED ARTICLE: Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Alzheimer model) in rat

et al. 2022

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Rosemary oil (ROO) is known to have multiple pharmacological effects: it is an antioxidant, an antiin ammatory, and cytoprotective. In the present study, we examined the effects of ROO on Human olfactory bulb neuronal stem cells (hOBNSCs) after their transplantation into rats, with the ibotenic (IBO) acid-induced cognitive de cit model. After 7 weeks, cognitive functions were assessed using the Morris water maze (MWM). After two months blood and the hippocampus were collected for biochemical, gene expression, and histomorphometric analyses. Learning ability and memory function were signi cantly enhanced after hOBNSCs transplantation and were nearly returned to normal in the treated group. The IBO acid injection was associated with a signi cant decline of total leukocyte count (TLC) and a signi cant increase in total and toxic neutrophils. As well, the level of IL-1β, TNF-α CRP in serum and levels of MDA and NO in hippocampus tissue were signi cantly elevated, while antioxidant markers (CAT, GSH, and SOD) were reduced in treated tissue compared to controls. The administration of ROO before or with cell transplantation attenuated all these parameters. In particular, the level of NO nearly returned to normal when rosemary was administrated before cell transplantation. Gene expression analysis revealed the potential protective effect of ROO and hOBNSCs via down-expression of R-βAmyl and R-CAS 3 and R-GFAP genes.

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Section: )mentioning

confidence: 97%

RETRACTED ARTICLE: Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Alzheimer model) in rat

et al. 2022

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“…Apoptosis further affects AD pathologies through the catalytic activities of caspases. For example, activated caspase-3 can directly cleave amyloid precursor protein (APP), producing additional APP fragments with cytotoxicity [25]. These fragments accumulate in the cortical and hippocampal regions of the brain as AD progresses.…”

Section: Functional Consequences Of Neural Cell Death In Ad 21 Pathol...mentioning

confidence: 99%

“…Caspase-3 cleaves the subunits of AMPA receptors to inhibit neuronal responsiveness to the neurotransmitter, glutamate. As a result, AD patients and AD transgenic mouse models show severe spatial learning and memory deficits due to neuronal loss and neurodegeneration [25,27].…”

Section: Functional Consequences Of Neural Cell Death In Ad 21 Pathol...mentioning

confidence: 99%

The Molecular Mechanisms of Neuroinflammation in Alzheimer’s Disease, the Consequence of Neural Cell Death

Choi

Kwon

Kim

et al. 2023

IJMS

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Alzheimer’s disease (AD) is accompanied by neural cell loss and memory deficit. Neural cell death, occurring via apoptosis and autophagy, is widely observed in the AD brain in addition to neuroinflammation mediated by necroptosis and the NLRP3 inflammasome. Neurotoxicity induced by amyloid-beta (Aβ) and tau aggregates leads to excessive neural cell death and neuroinflammation in the AD brain. During AD progression, uncontrolled neural cell death results in the dysregulation of cellular activity and synaptic function. Apoptosis mediated by pro-apoptotic caspases, autophagy regulated by autophagy-related proteins, and necroptosis controlled by the RIPK/MLKL axis are representative of neural cell death occurred during AD. Necroptosis causes the release of cellular components, contributing to the pro-inflammatory environment in the AD brain. Inordinately high levels of neural cell death and pro-inflammatory events lead to the production of pro-inflammatory cytokines and feed-forward hyper neuroinflammation. Thus, neural cell death and neuroinflammation cause synaptic dysfunction and memory deficits in the AD brain. In this review, we briefly introduce the mechanisms of neural cell death and neuroinflammation observed in the AD brain. Combined with a typical strategy for targeting Aβ and tau, regulation of neural cell death and neuroinflammation may be effective for the amelioration of AD pathologies.

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3-Acetyl coumarin alleviate neuroinflammatory responses and oxidative stress in aluminum chloride-induced Alzheimer’s disease rat model

Zeb,

Sharif,

Akhtar

et al. 2024

Inflammopharmacol

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Evaluation of Caspase-3 mRNA Gene Expression Activity in Amyloid Beta-induced Alzheimer’s Disease Rats

Cited by 6 publications

References 55 publications

RETRACTED ARTICLE: Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Alzheimer model) in rat

RETRACTED ARTICLE: Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Alzheimer model) in rat

The Molecular Mechanisms of Neuroinflammation in Alzheimer’s Disease, the Consequence of Neural Cell Death

3-Acetyl coumarin alleviate neuroinflammatory responses and oxidative stress in aluminum chloride-induced Alzheimer’s disease rat model

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