Evaluation of cell proliferation in ear and lymph node using BrdU immunohistochemistry for mouse ear swelling test

Lee, Jong Kwon; Park, Jae Hyun; Kim, Hyung Soo; Chung, Seung Tae; Eom, Juno H.; Nam, Ki Taek; Oh, Hye Young

doi:10.1016/s1382-6689(03)00025-5

Cited by 8 publications

(2 citation statements)

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“…The skin is a multilayered organ and anatomically, it has many histological defined layers: the stratified, avascular, cellular epidermis, the underlying dermis connective tissue and a subcutaneous fat layer. Moreover, the highly vascularized dermis and the epidermis support several skin appendages (41). Chronic skin treatment with sodium lauryl sulfate causes extensive damage (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the complex containing formulation seems to be adequate for topical application of KP, although it is important to mention that the MEST is less reliable for detecting weak to moderate sensitizers (41). It has been reported that in controlled clinical studies, local skin reactions and systemic side effects are not more common than in placebo.…”

Section: Resultsmentioning

confidence: 99%

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Transdermal Delivery of Ketoprofen: The Influence of Drug–Dioleylphosphatidylcholine Interactions

et al. 2006

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DSC determinations in the complex showed enthalpy and temperature depressions, indicating KP and DOPC interaction. In addition, dipole-dipole interactions between the KP carboxylic acid and OH groups in phospholipids were shown by 1H NMR studies. Based on the NMR studies, a KP-DOPC binding model is proposed, in which KP is involved by the two long aliphatic chains of the phospholipid. Solubility studies indicated that DOPC improved drug solubility. KP permeation was enhanced by both formulations tested, but the complex also increased its skin uptake. Such behavior could be attributed to the solubilizing, melting and enhancing effects of DOPC. Skin irritation and hypersensitivity were not significantly changed compared to control, suggesting that the formulation may be therapeutically explored for KP transdermal delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%