Evaluation of cellular antioxidant and antiproliferative activities of five main phyllanthus emblica L. cultivars in China

Li, Y; Sun, Haiyan; Yu, Xiangying; Liu, D; Wan, Hongxia

doi:10.4103/0250-474x.159608

Cited by 12 publications

(3 citation statements)

References 31 publications

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“…It has been shown earlier that P. emblica fruits’ water extract prepared according to Thai Herbal Pharmacopoeia can act as a strong inhibitor against H 2 O 2 ‐induced cellular oxidative stress (Charoenteeraboon et al, ). Similarly, Li et al have reported that five main cultivators of P. emblica from China possess intracellular radical scavenging capability as analyzed on HepG2 liver cancer cells (Li, Sun, Yu, Liu, & Wan, ).…”

Section: Resultsmentioning

confidence: 94%

Bioactive constituents of Emblica officinalis overcome oxidative stress in mammalian cells by inhibiting hyperoxidation of peroxiredoxins

et al. 2019

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Emblica officinalis (Amla) is a renowned fruit having nutritional and medicinal traits mostly linked to its antioxidants content. In the current study, the methanolic crude extract of amla fruit is subjected to sequential fractionation to get its partially purified fractions. The ethyl acetate (EA) and butanol (BUT) fractions of amla showed maximum antioxidant potential. The ferric reducing capability and nitric oxide scavenging activity were highest in EA fraction. One of the highlights of the study is the cellular antioxidant assay conducted in HeLa cells. Additionally, HeLa cells pre‐treated with EA and BUT fractions were able to combat oxidative stress via total reduction in hyperoxidation of intracellular peroxiredoxin enzyme. Gallic acid, ascorbic acid, ellagic acid, rutin, quercetin, and catechol are the major compounds present in these fractions as identified by LC‐ESI‐MS followed by their quantification by HPLC. These findings indicate that components of E. officinalis can protect intracellular oxidative stress‐mediated degeneration. Practical applications The study highlighted that E. officinalis is a promising source of phenolics and flavonoids acting as natural antioxidants, which showed varied potential to scavenge ROS. Also, the plant fractions were able to fight intracellular oxidative stress via total reduction in hyperoxidation of the human peroxiredoxin. In conclusion, we can say that the regular intake of such food supplements that affect important antioxidant enzymes can be of special interest in the management of oxidative stress‐mediated human ailments.

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Section: Resultsmentioning

confidence: 94%

Bioactive constituents of Emblica officinalis overcome oxidative stress in mammalian cells by inhibiting hyperoxidation of peroxiredoxins

et al. 2019

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“…Phyllanthus emblica has a high antioxidant capacity owing to its high content of polyphenolic compounds and vitamin C. The fruit extract can be used as an antioxidant and can inhibit lipid peroxidation and scavenge free radicals such as superoxide anions, hydrogen radicals, hydrogen peroxide and nitric oxide radicals [ 131 , 132 ]. One study investigated the effect of oral intake of fruit extracts in combination with vitamin E and carotenoids on repigmentation in patients with vitiligo after phototherapy [ 133 ].…”

Section: Potential Therapeutic Approaches To Reduce Oxidative Stressmentioning

confidence: 99%

Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review

Białczyk,

Wełniak,

Kamińska

et al. 2023

Mol Diagn Ther

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Vitiligo is a chronic skin disorder characterised by the loss of melanocytes and subsequent skin depigmentation. Although many theories have been proposed in the literature, none alone explains the pathogenesis of vitiligo. Oxidative stress has been identified as a potential factor in the pathogenesis of vitiligo. A growing body of evidence suggests that antioxidant therapies may offer a promising approach to managing this condition. This review summarises the potential mechanisms of oxidative stress and the types of melanocyte death in vitiligo. We also provide a brief overview of the most commonly studied antioxidants. Melanocytes in vitiligo are thought to be damaged by an accumulation of reactive oxygen species to destroy the structural and functional integrity of their DNA, lipids, and proteins. Various causes, including exogenous and endogenous stress factors, an imbalance between prooxidants and antioxidants, disruption of antioxidant pathways, and gene polymorphisms, lead to the overproduction of reactive oxygen species. Although necroptosis, pyroptosis, ferroptosis, and oxeiptosis are newer types of cell death that may contribute to the pathophysiology of vitiligo, apoptosis remains the most studied cell death mechanism in vitiligo. According to studies, vitamin E helps to treat lipid peroxidation of the skin caused by psoralen ultra-violet A treatment. In addition, Polypodium leucotomos increased the efficacy of psoralen ultra-violet A or narrow-band ultraviolet B therapy. Our review provides valuable insights into the potential role of oxidative stress in pathogenesis and antioxidant-based supporting therapies in treating vitiligo, offering a promising avenue for further research and the development of effective treatment strategies.

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“…Instead, an extremely high vitamin C content (290–468 mg/100 g of raw fruit) (Srinivasan, ) provides the ability to reduce other LMWA. Indeed, the extract of fruit can inhibit lipid peroxidation and scavenge free radicals such as superoxide anion radical, hydrogen radical, hydrogen peroxide, and nitric oxide radical (Li, Sun, Yu, Liu, & Wan, ). One research studied the effect of oral supplementation of fruit extract mixed with vitamin E and carotenoids on repigmentation in vitiligo patients followed the phototherapy (Colucci et al, ).…”

Section: Functional Foodsmentioning

confidence: 99%

Functional nutrition as integrated approach in vitiligo management

Nardo

Barygina

França

et al. 2018

Dermatologic Therapy

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Vitiligo is a common disease of unknown cause that produces disfiguring white patches of depigmentation that can be treated using various new and experimental therapies, such as narrow-band ultraviolet B (NB-UVB) microphototherapy, NB-UVB excimer laser, and monochromatic excimer light. Medical treatments include topical corticosteroids and other topical treatments, such as antioxidants, tacrolimus and pimecrolimus, prostaglandin E, and vitamin D derivatives (Lotti, Berti, & Moretti, ). The goal of treating vitiligo is to make it less noticeable either by restoring lost pigment or by eliminating remaining pigment. Functional foods and healthy diet, with nutrients, form a variety of sources, could be considered an integral part, as well as helpful, of vitiligo's medical therapy.

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Evaluation of cellular antioxidant and antiproliferative activities of five main phyllanthus emblica L. cultivars in China

Cited by 12 publications

References 31 publications

Bioactive constituents of Emblica officinalis overcome oxidative stress in mammalian cells by inhibiting hyperoxidation of peroxiredoxins

Bioactive constituents of Emblica officinalis overcome oxidative stress in mammalian cells by inhibiting hyperoxidation of peroxiredoxins

Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review

Functional nutrition as integrated approach in vitiligo management

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