Evaluation of Cellulose Xanthate-Metal-Tetracycline Complexes as a Polymeric Antibacterial Agent with Prolonged Antibacterial Activity

Jung, Yunjin; Kim, Young Mi

doi:10.1080/10717540701828723

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…Compared with a mixture of cellulose, metal and tetracycline, the tetracycline release from the cellulose-metal-tetracycline complexes was greatly sustained, which have been manifested by the antibacterial activity lasted for 7-22 days. 65 In addition, formation of complex can modify the hydrophobicity of the drug, which also has an influence on the drug release. Gentamicin was assembled into a hydrophobic complex by hydrophobic ion pairing with the anionic surfactant bis(2-ethylhexyl) sulfosuccinate sodium salt (AOT).…”

Section: Antibiotic Materials Extended-release Dds P Gao Et Almentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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Section: Antibiotic Materials Extended-release Dds P Gao Et Almentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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“…Subsequently, extensive structural analyses were performed by Haiduc and Tiekink, which showed that these ligands can coordinate to metal atoms in a monodentate, isobidentate, or anisobidentate fashion. Metal xanthates are extensively used as pharmaceuticals [15], fungicides [16], pesticides [17], corrosion inhibitors [18], agricultural reagents [19], and quite recently in therapy for HIV infections [20]. The last two decades have witnessed a tremendous development of new radical reactions designed for organic synthesis [21,22].…”

Section: Introductionmentioning

confidence: 99%

O-Tolyl/benzyl dithiocarbonates of phosphorus(III) and (V): syntheses and characterization

et al. 2012

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O-Tolyl/benzyl dithiocarbonates, ROCS 2 Na (R = o-, m-, or p-CH 3 C 6 H 4 -, and -CH 2 C 6 H 5 ), were synthesized and characterized. These new ligands reacted with PCl 3 /POCl 3 in refluxing toluene which resulted in the formation of phosphorus(III) and phosphorus(V) tolyl/ benzyl dithiocarbonates corresponding to [(ROCS 2 ) n PCl 3-n ] and [(ROCS 2 ) n POCl 3-n ] (R = o-, m-, or p-CH 3 C 6 H 4 -, and -CH 2 C 6 H 5 ; n = 1, 2, 3). These pale yellow liquid compounds were characterized by IR, mass, and NMR ( 1 H, 13 C, and 31 P) spectral studies, which suggest the dithiocarbonate ligands bind in a monodentate mode leading to P-S-C linkages in these derivatives.

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Biological Aspects of Metal Enolates

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2010

Patai's Chemistry of Functional Groups

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Evaluation of Cellulose Xanthate-Metal-Tetracycline Complexes as a Polymeric Antibacterial Agent with Prolonged Antibacterial Activity

Cited by 8 publications

References 11 publications

Recent advances in materials for extended-release antibiotic delivery system

Recent advances in materials for extended-release antibiotic delivery system

O-Tolyl/benzyl dithiocarbonates of phosphorus(III) and (V): syntheses and characterization

Biological Aspects of Metal Enolates

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