Evaluation of Cerebellar and Cerebral Volume in Migraine with Aura: A Stereological Study

Yilmaz-Küsbeci, Özge; Göçmen-Mas, Nüket; Yücel, Aylin; Karabekir, Hamit Selim; Ertekın, Tolga; Yazıcı, Ayşe Canan

doi:10.1007/s12311-010-0167-8

Cited by 12 publications

(9 citation statements)

References 55 publications

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“…In headache/migraine, changes in GM volume are not haphazard across the brain but tend to involve specific and highly organized cerebral areas. Although some studies (91, 92) did not find differences in cerebellar, global, and regional (ie, GM and WM) cerebral volumes between patients with migraine and normal subjects, other studies have questioned this finding. In fact, migraineurs showed atrophy in regions involved in central pain processing (anterior and posterior cingulate cortices, insula, orbitofrontal cortex, prefrontal cortex, posterior parietal cortex) (93–95), but not in those specific for migraine (eg, brainstem).…”

Section: Understanding Mechanisms and Tracking Clinical Progression Omentioning

confidence: 98%

Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia

Kharfan‐Dabaja

Chávez

Khorfan

et al. 2008

Cancer

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The past 2 decades have brought major advances to clinicians' understanding of the complexities of chronic lymphocytic leukemia (CLL). Novel biologic and genetic markers are providing tools for more accurate prediction of responses, disease progression, and survival of patients across different stages of CLL. Several multivariate analyses have confirmed unmutated IgVH to be an independent adverse prognostic marker in patients with CLL. The presence of unmutated IgVH is strongly associated with poor-risk genomic aberrations and overexpression of CD38 and ZAP-70. Nevertheless, these associations are not absolute. The design of future clinical trials are already incorporating novel prognostic markers such as IgVH, among others, as part of risk-adapted strategies aimed at improving treatment outcomes by tailoring the aggressiveness of the therapy proportional to disease risk. Such a strategy could minimize unnecessary chemotoxicity in patients with favorable prognosis CLL, while reserving more aggressive therapy, including allogeneic hematopoietic cell transplantation, for patients with poor-risk features.

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Section: Understanding Mechanisms and Tracking Clinical Progression Omentioning

confidence: 98%

Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia

Kharfan‐Dabaja

Chávez

Khorfan

et al. 2008

Cancer

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“…Their results suggest that patients with migraine with aura do not have a significant difference in cerebellar and cerebral volumes and cerebellar/cerebral volume ratios compared to the non-migraine group. 39 We concluded in our study based on shape analysis method that the cerebellum shape was not influenced in migraine. Although general shape differences were not found in cerebellum, there were some regional changes in migraine patients.…”

Section: Discussionmentioning

confidence: 53%

“…1,11,[38][39][40] Cerebellar abnormalities are thought to be the underlying cause for functional and metabolic disturbances in migraine. Brain balance changes have been recognized in migraine, but cerebellar function between or during attacks have been assessed only in a few studies.…”

Section: Discussionmentioning

confidence: 99%

Statistical Shape Analysis of the Corpus Callosum and the Cerebellum in Migraine Patients

Sığırlı¹,

Ozdemir²,

Ercan³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T OOb bj je ec ct ti iv ve e: : The aim of this study was to investigate the shape differences in the corpus callosum and cerebellum of migraine patients compared with healthy controls and to assess whether migraine attack frequency and disease duration are indicators for brain abnormalities in migrain cases. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study included magnetic resonance imaging scans of 25 control subjects and 38 migraine patients. The data were obtained from the coordinate of landmarks analyzed with statistical shape analysis. A generalized Procrustes analysis was used to investigate shape differences. Witelson subdivision was used to further assess the regional shape differences in corpus callosum. R Re es su ul lt ts s: : The shape of the corpus callsoum in controls was significantly different from the shape in migraine patients. Migraine patients had deformations in corpus callosum compared to control patients where the most prominent deformations were seen in the posterior midbody of corpus callosum. According to Witelson subdivions deformation in in the rostral body was less prominent. There was no global or regional shape difference between patients with migraine and controls for cerebellum. No significant correlation was recognized between the size and disease duration or frequency of migraine attacks, both for corpus callosum and cerebellum. C Co on nc cl lu us si io on n: : The data suggest that migraine sufferers have global structural changes in corpus callosum but not in cerebellum, and that deformations did not vary with the disease progress. K Ke ey y W Wo or rd ds s: : Cerebellum; corpus callosum; geometric morphometrics; migraine; statistical shape analysis Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı, kontrollerle karşılaştırıldığında migren hastalarının korpus kallozum ve serebellumundaki şekil farklılıklarını araştırmak ve migren atak frekansı ile hastalık süre-sinin migren hastalarında beyin anormalliklerini etkileyip etkilemediğini değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma, 25 kontrol ve 38 migren hastasından elde edilen manyetik rezonans görün-tüleri kullanılarak gerçekleştirilmiştir. Mirengi noktası koordinatlarından elde edilen veriler, istatistiksel şekil analizi ile incelenmiştir. Şekil farklılıklarını değerlendirmede genelleştirilmiş Procrustes analizi kullanılmıştır. Korpus kallozumdaki bölgesel şekil farklılıklarını daha iyi değerlendirebilmek için Witelson alt bölgelendirme analizi dikkate alınmıştır. B Bu ul lg gu ul la ar r: : Korpus kallozumun şekli açısın-dan kontrol olguları ve migren hastaları arasında anlamlı bir fark bulunmuştur. Korpus kallozum için, migren hastalarında kontrollere oranla deformasyonlar olduğu gözlenmiştir. En belirgin deformasyonlar korpus kallozumun posterior orta gövdesinde gözlenmiştir. Witelson alt bölgelendirme analizine göre, korpus kallozumun rostral gövdesinde çok daha az miktarda deformasyon gözlenmiştir. Diğer taraftan, serebellum açısından, mi...

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“…Migraine (Rocca et al, 2003a;Rocca et al, 2003b;Rocca et al, 2006a;Rocca et al, 2006b;Absinta et al, 2012) MRI and VBM Subtle grey matter lesions using T1-weighted MRI, and VBM. Visible on T2-weighted MRI Migraine (Adami et al, 2008;Agarwal et al, 2008;Del Sette et al, 2008;Rao et al, 2008;Rigatelli, 2008;Rocca et al, 2008;Schmitz et al, 2008a;Valfre et al, 2008;Bugnicourt et al, 2009;Kruit et al, 2010;Yilmaz-Kusbeci et al, 2010;Trauninger et al, 2011;Maggioni et al, 2012;Palm-Meinders et al, 2012;Rotstein et al, 2012;Aradi et al, 2013;Dinia et al, 2013;Seneviratne et al, 2013) are VBM and surface-based morphometry (SBM). Some of the pitfalls of the traditional ROI-based morphometry are as follows: (i) it is used primarily on large areas, and therefore smaller differences may be overlooked; and (ii) it is a time-consuming process and cannot be used for assessing large datasets.…”

Section: Structural Mri Studiesmentioning

confidence: 99%

Recent progress in migraine pathophysiology: role of cortical spreading depression and magnetic resonance imaging

Bhaskar

Saeidi

Borhani

et al. 2013

Eur J of Neuroscience

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Migraine is characterised by debilitating pain, which affects the quality of life in affected patients in both the western and the eastern worlds. The purpose of this article is to give a detailed outline of the pathophysiology of migraine pain, which is one of the most confounding pathologies among pain disorders in clinical conditions. We critically evaluate the scientific basis of various theories concerning migraine pathophysiology, and draw insights from brain imaging approaches that have unraveled the prevalence of cortical spreading depression (CSD) in migraine. The findings supporting the role of CSD as a physiological substrate in clinical pain are discussed. We also give an exhaustive overview of brain imaging approaches that have been employed to solve the genesis of migraine pain, and its possible links to the brainstem, the neocortex, genetic endophenotypes, and pathogenetic factors (such as dopaminergic hypersensitivity). Furthermore, a roadmap is proposed to provide a better understanding of pain pathophysiology in migraine, to enable the development of strategies using leads from brain imaging studies for the identification of early biomarkers, efficient prognosis, and treatment planning, which eventually may help in alleviating some of the devastating impact of pain morbidity in patients afflicted with migraine.

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Evaluation of Cerebellar and Cerebral Volume in Migraine with Aura: A Stereological Study

Cited by 12 publications

References 55 publications

Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia

Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia

Statistical Shape Analysis of the Corpus Callosum and the Cerebellum in Migraine Patients

Recent progress in migraine pathophysiology: role of cortical spreading depression and magnetic resonance imaging

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