Evaluation of Certain Psychopharmacological Compounds

2-Oxazolidones

“…In the other (44), an epoxide ring was first opened with aqueous hydrochloric acid to give the chlorohydrin which then underwent displacement of chloride by cyanate ion (Eq 18). The intermediate isocyanate o-C1C,H4 [185][186][187][188] (3), [192][193][194]…”

“…While the two substances discussed above find their major uses in controlling infection, 5-(o-methoxyphenoxymethyl)-2-oxazolidone, or Methoxadone or Mephenoxalone, is used as a psychopharmacological (187) or neuropharmacological (208) compound. Its toxicity (51,601), pharmacological activity (89,95,349,601), metabolic fate (356), adrenolytic action (2), synergistic action with morphine, codeine, and the like (174), effect on reproduction (500), and its effect on blood pressure and behavioral responses (3) have been studied.…”

Comparison of Different Photobeam Arrangements for Measuring Spontaneous Activity of Mice

“…This instrument has been used extensively in the preliminary evaluation of potential psychotropic agents, for measuring their ability to alter the normal spontaneous locomotor activity of small animals. Variations of this apparatus, used for testing drug effects, have included a rectangular single-beam cage (l), and a circular arena with two beams (2) or six beams (3, 4) activating a single counter. Investigation of the conditions which maximize the sensitivity and reliability of this measuring instrument may contribute scientific knowledge about the interactions of experimental variables with drug effects and also may be of practical use in evaluating compounds.…”

Central Activity of Aqueous Extracts of Piper methysticum (Kava)

“…Spontaneous Motor Activity (SMA) and Rotarod Performance (RRP).-The effects of the lyophilized extracts on the SMA and RRP of male albino Swiss-Webster mice were evaluated by a method previously described by Furgiuele et nl. (17,18). One hour after receiving an intraperitoneal injection of either LE-I, LE-11, LE-111, or saline, groups of five mice were placed in photocell activity cages.…”