Evaluation of changes in neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients with vitiligo

Saraç, Gülbahar; Altunışık, Nihal; Şener, Serpil; Hakverdi, Gülden

doi:10.5455/annalsmedres.2019.03.152

Cited by 2 publications

(4 citation statements)

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“…In the study, no significant differences were determined between vitiligo patients and control groups in terms of age and gender (Table 1). A recent study declared that no statistically significant differences were found in terms of PLT between vitiligo patients and controls ( p = 0.117) 44 . On contrary, significant differences were found in terms of PLT between both groups in our study ( p = 0.00).…”

Section: Discussioncontrasting

confidence: 96%

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Evaluation of the association between platelet tests and thyroid‐stimulating hormone levels in patients with vitiligo

Saraç

İbiş

Akdağ

2022

J of Cosmetic Dermatology

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Objective Vitiligo is a common dermatological disease of unknown cause and progressing with depigmentation and affects approximately 1% of the world population. In the study, we aimed to compare plateletcrit (PCT), mean platelet volume (MPV), platelet (PLT), and thyroid‐stimulating hormone (TSH) values in vitiligo patients. Material and Methods We retrospectively evaluated the medical data of 100 patients who were admitted to the dermatology outpatient clinic between January 2020 and December 2021 with a diagnosis of vitiligo. The control group was retrospectively constituted from medical records of 90 healthy individuals. PCT, MPV, PLT, and TSH levels of both groups were compared statistically. Results A total of 190 participants (100 vitiligo patients and 90 healthy volunteers) were included in the study. The mean age of the patient group was 38.62 ± 1.62, while the mean age of the control group was 41.52 ± 1.54. There were no differences between the two groups in terms of age and gender. It was found that the mean MPV value in the patient group was lower than the control group (p = 0.00). PLT and PCT values were significantly higher in the patient group than the control group (p = 0.00, p = 0.01, respectively). There was no statistically significant difference between the two groups in terms of TSH (p > 0.05). A negative correlation between MPV and PLT values in the patient group (r = −0.218, p = 0.029), and a negative correlation between MPV and TSH (r = −0.218, p = 0.029), (−0.230, p = 0.021). Conclusion In the study, a comparison of the PCT, MPV, and PLT levels showed a difference between both groups, but no differences in TSH levels. To clarify these results, comprehensive studies with more samples are needed.

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Section: Discussioncontrasting

confidence: 96%

“…A recent study declared that no statistically significant differences were found in terms of PLT between vitiligo patients and controls (p = 0.117). 44 On contrary, significant differences were found in terms of PLT between both groups in our study (p = 0.00).…”

Section: Discussioncontrasting

confidence: 79%

Evaluation of the association between platelet tests and thyroid‐stimulating hormone levels in patients with vitiligo

Saraç

İbiş

Akdağ

2022

J of Cosmetic Dermatology

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“…increased systemic inflammation 11. However, it differs from Sarac et al 's study that there was no significant increase in NLR in patients with vitiligo compared to controls 12. …”

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confidence: 76%

“…Vitiligo is a disease whose exact cause is unknown but is thought to occur due to genetic, autoimmune, and biochemical disorders. 12 Research conducted by Solak et al showed that patients with generalized vitiligo significantly increased NLR values. This appears to be related Several hypotheses suggest that vitiligo is a genetic, neurohormonal, oxidative stress and autoimmune predisposition as the pathophysiology of vitiligo.…”

Section: Vitiligomentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio (NLR) in dermatology perspective: a review

Maharani,

Mahariski,

Izawati

et al. 2023

BDVAJ

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The neutrophil-to-lymphocyte ratio (NLR) is the ratio between the number of neutrophils and lymphocytes in the peripheral blood. Neutrophils are responsible for an initial immune response to pathogens that enter the body through the mechanisms of chemotaxis, phagocytosis, the release of reactive oxygen species (ROS), granular proteins, production and release of cytokines. Neutrophils also have an important role in the occurrence of the systemic inflammatory response (SIRS). There are several types of diseases in the field of dermatology that are also related to NLR. It is associated with the presence of an inflammatory process. In addition, NLR is considered an easy, inexpensive, and reproducible parameter associated with clinical outcomes and disease severity. Several diseases in the field of dermatology found to be associated with NLR include leprosy, Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), psoriasis, vitiligo, atopic dermatitis, systemic sclerosis, and skin cancer. In recent years, its role as an independent prognostic factor for neoplasms and as an inflammatory biomarker in various acute and chronic diseases has been increasingly established in the dermatology field. However, not all studies have found significant results. One of them is vitiligo which still finds controversial results. For this reason, this literature review will discuss specifics related to several diseases in dermatology associated with NLR.

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Evaluation of changes in neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients with vitiligo

Cited by 2 publications

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Evaluation of the association between platelet tests and thyroid‐stimulating hormone levels in patients with vitiligo

Evaluation of the association between platelet tests and thyroid‐stimulating hormone levels in patients with vitiligo

Neutrophil-to-lymphocyte ratio (NLR) in dermatology perspective: a review

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