Evaluation of Chemical and Antiviral Properties of Essential Oils from South American Plants

Duschatzky, Claudia; Possetto, Mirta; Talarico, Laura; Garcı́a, Cybele C.; Michis, Fabiana; Almeida, Norma; Lampasona, Marina P. de; Schuff, Carola; Damonte, Elsa B.

doi:10.1177/095632020501600404

Cited by 75 publications

(39 citation statements)

References 18 publications

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“…L. origanoides, Pimenta racemosa, Illiciom verum and Zingiber officinalis showed a 50% reduction of the viral plaque numbers at 100 µg/mL (unpublished data). In contrast, in studies evaluating the viral inhibitory effect of the essential oil from eight species of aromatic plants from Argentina, only Artemisia douglasiana and Eucalyptus patens had any discernible virucidal effect on DENV-2 replication in vitro (Garcia et al 2003, Duschatzky et al 2005. our results agree with other studies testing distinct natural products against DENV.…”

Section: Resultscontrasting

confidence: 35%

Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

Ocazionez

Meneses

Torres

et al. 2010

Mem. Inst. Oswaldo Cruz

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The inhibitory effect of Lippia alba and Lippia citriodora essential oils on dengue virus serotypes replication in vitro was investigated. The cytotoxicity (CC 50 ) was evaluated by the MTT assay and the mode of viral inhibitory effect was investigated with a plaque reduction assay. The virus was treated with the essential oil for 2 h at 37 o C before cell adsorption and experiments were conducted to evaluate inhibition of untreated-virus replication in the presence of oil. Antiviral activity was defined as the concentration of essential oil that caused 50% reduction of the virus plaque number (IC 50 ). L. alba oil resulted in less cytotoxicity than L. citriodora oil (CC 50 : 139.5 vs. 57.6 µg/mL). Virus plaque reduction for all four dengue serotypes was observed by treatment of the virus before adsorption on cell. The IC 50 values for L. alba oil were between 0. 4-32.6 µg/mL and between 1.9-33.7 µg/mL for L. citriodora oil. No viral inhibitory effect was observed by addition of the essential oil after virus adsorption. The inhibitory effect of the essential oil seems to cause direct virus inactivation before adsorption on host cell.Key words: essential oil -antiviral -virucidal activity -dengue virus -Lippia sp.Dengue is an acute illness characterised by the hemorrhagic fever caused by dengue virus (DENV) that is transmitted to humans by Aedes mosquitoes. DENV infection results in a spectrum of disease ranging from a mild febrile illness or dengue fever to a severe disease or dengue hemorrhagic fever/dengue shock syndrome. Among the human arboviral diseases, dengue is responsible for causing most illness and death. It has been estimated that 50-100 million dengue infections occur each year in tropical urban areas around the world with 20,000-25,000 deaths (Gubler 2006).DENV is a member of the Flaviviridae family and it exists as four related serotypes (DENV-1 2, 3 and 4). The virus possesses an icosahedral nucleocapsid core surrounded by a host-derived lipid membrane (envelope), in which the envelope (E) protein and membrane (M) protein are embedded. The Flavivirus enters into the host cell by receptor-mediated endocytosis into coated vesicles, a process in which the E protein plays the major role. The E protein mediates interactions within the virus and the components of the host cell membrane involved in virus adsorption and the E protein interacts with the membrane cell during fusion (Lindenbach & Rice 2007). Compounds that interact with sites on the E protein that binds to structures on the cellular membrane affect the adsorption and fusion process. That interferes There is no antiviral drug for treatment for any of the Flavivirus and an effective vaccine for human use is not yet available to prevent dengue. Consequently, the development of antiviral drugs licensed for treatment of patients remains an urgent need to prevent dengue fatalities. Compounds obtained from traditional medicinal plants and herbs species have been reported to have antiviral activity and a wide variety of active phytochemicals hav...

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Section: Resultscontrasting

confidence: 35%

Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

Ocazionez

Meneses

Torres

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…Such cytotoxic activity is of great interest for applications against some human or animal pathogens and parasites, as well as for the preservation of agricultural and marine products [29]. It has been known for centuries that aromatic plants-mainly their essential oils or components-can act versus a large variety of organisms including bacteria, viruses, fungi, protozoa, parasites and insects [31][32][33][34][35]. Moreover, the essential oils can exhibit hypolipidemic [36], antioxidant [37], digestive stimulant [38], and antitoxigenic [39] activities and can also contribute in odor and ammonia control [10].…”

Section: Essential Oilsmentioning

confidence: 99%

Aromatic Plants as a Source of Bioactive Compounds

Bonos²,

et al. 2012

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Aromatic plants, also known as herbs and spices, have been used since antiquity as folk medicine and as preservatives in foods. The best known aromatic plants, such as oregano, rosemary, sage, anise, basil, etc., originate from the Mediterranean area. They contain many biologically active compounds, mainly polyphenolics, which have been found to possess antimicrobial, antioxidant, antiparasitic, antiprotozoal, antifungal, and anti-inflammatory properties. Currently, the demand for these plants and their derivatives has increased because they are natural, eco-friendly and generally recognized as safe products. Therefore, aromatic plants and their extracts have the potential to become new generation substances for human and animal nutrition and health. The purpose of this review is to provide an overview of the literature surrounding the in vivo and in vitro use of aromatic plants.

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“…Oils from tea tree and eucalyptus [211], anise (Illicium verum), hyssop (Hyssopus officinalis), thyme (Thymus vulgaris), ginger (Zingiber officinale), chamomile (Matricaria recutita) and sandalwood (S. album) [212], A. aborescens [53,213], H. cordata [207], L. scoparium [214], Melaleuca ericifolia, M. leucadendron and M. armillaris [215], Melissa officinalis [216,217], M. piperita [218], O. crocata [208], Salvia fructicosa [219], S. limbata and S. sclarea [209], S. album [220], Santolina insularis [221,222], a range of South American plants including Aloysia, Artemisia and Lippia spp. [223,224], and the components eugenol [225,226] and isoborneol [227] have been tested against HSV-1 and/or -2. Minami et al [228] tested oils from Cupressus sempervirens (cypress), Juniperus communis (juniper), M. alternifolia (tea tree), Ocimum basilicum album (tropical basil), M. piperita (peppermint), Origanum majorana (marjoram), Eucalyptus globulus (eucalyptus), Ravensara aromatica (ravensara), Lavandula latifolia (lavender), Citrus limonum (lemon), Rosmarinus officinalis (rosemary) and Cymbopogon citrates (lemongrass) against HSV-1.…”

Section: Antiviral Activitymentioning

confidence: 99%

“…Apart from the more widely tested influenza virus and HSV, dengue virus type 2 and Junin virus [223,224], adenovirus and mumps virus [230], human respiratory syncytial virus [231], HIV [232], Newcastle disease virus [205], poliovirus [208], tobacco mosaic virus [233], two bacteriophage [234], yellow fever virus [235] and the viral aetiological agent of severe acute respiratory syndrome, a novel coronavirus [236], have also been tested against a range of oils and components with similar results.…”

Section: Antiviral Activitymentioning

confidence: 99%