Evaluation of chemopreventive and cytotoxic effect of lemon seed extracts on human breast cancer (MCF-7) cells

Kim, Jinhee; Jayaprakasha, G.K.; Uckoo, Ram M.; Patil, Bhimanagouda S.

doi:10.1016/j.fct.2011.10.057

Cited by 53 publications

(36 citation statements)

References 46 publications

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“…Furthermore, methanolic extract of lemon fruit triggered apoptosis of MCF-7 human breast cancer cells [227]. An analogous effect was achieved on the same cell line using lemon seed extract [228]. …”

Section: Anti-cancer Properties Of Citrus Juices and Extractsmentioning

confidence: 98%

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

et al. 2016

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Fruits and vegetables have long been recognized as potentially important in the prevention of cancer risk. Thus, scientific interest in nutrition and cancer has grown over time, as shown by increasing number of experimental studies about the relationship between diet and cancer development. This review attempts to provide an insight into the anti-cancer effects of Citrus fruits, with a focus on their bioactive compounds, elucidating the main cellular and molecular mechanisms through which they may protect against cancer. Scientific literature was selected for this review with the aim of collecting the relevant experimental evidence for the anti-cancer effects of Citrus fruits and their flavonoids. The findings discussed in this review strongly support their potential as anti-cancer agents, and may represent a scientific basis to develop nutraceuticals, food supplements, or complementary and alternative drugs in a context of a multi-target pharmacological strategy in the oncology.

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Section: Anti-cancer Properties Of Citrus Juices and Extractsmentioning

confidence: 98%

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

et al. 2016

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“…The highest radical scavenging activity and inhibition of MCF-7 cells in the MTT assay was exhibited by the methanol:water (80:20) extract which contained a high percentage of glucosides [86]. Poulose et al [89] have also studied the anticancer and antioxidant activities of different CLs: 11, 12, deacetylnomilinic acid 17-β-D-glucopyranoside (13), and nomilinic acid 17-β-D-glucopyranoside (14).…”

Section: In Vitro Testsmentioning

confidence: 99%

The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

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“…Over 300 limonoids have been isolated, with large quantities found in citrus juices (350-400 g/g in orange juice) as water-soluble limonoid glucosides, or in seeds as water-insoluble limonoidaglycones (Ejaz et al, 2006). While the importance of limonoids for humans is unclear, initial studies have shown that they could be useful in preventing and/or treating cancer in humans (Ejaz et al, 2006;Kim et al, 2012).…”

Section: Terpenesmentioning

confidence: 99%

The Influence of Pre‐ and Postharvest Environmental Stress on Fruit Bioactives

Burritt¹

2013

Bioactives in Fruit

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Evaluation of chemopreventive and cytotoxic effect of lemon seed extracts on human breast cancer (MCF-7) cells

Cited by 53 publications

References 46 publications

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

The Chemistry and Pharmacology of Citrus Limonoids

The Influence of Pre‐ and Postharvest Environmental Stress on Fruit Bioactives

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