Evaluation of childhood pancreas solid pseudopapillary tumors

Abstract

OBJECTIVE:Solid pseudopapillary tumor (SPT) of the pancreas is an extremely rare primary tumor in the pediatric age group. It has a low malignant potential and the prognosis is good if radical resection of the tumor is performed. Local recurrence and distant metastasis has only rarely been reported following incomplete resection.METHODS:A retrospective review of the medical records of 6 patients diagnosed as SPT according to a histopathological examination at the Children’s Hospital of Erciyes University School of Medicine between 2010 and 2017 was performed. Demographic characteristics, tumor localization and size, diagnostic method, immunohistochemical staining features, and medical and surgical treatments employed were recorded.RESULTS:There were 4 girls and 2 boys with the diagnosis of SPT included in this study. The mean age of the patients was 14 years (min-max: 13–16 years). The most common presenting complaint was abdominal pain. The mass lesion was at the head of the pancreas in 3 cases (50%) and the tail of the pancreas in the remaining 3 patients (50%). A Whipple procedure was performed in 3 cases, a distal pancreatectomy in 1, a distal pancreatectomy plus splenectomy in 1, and a subtotal pancreatectomy in 1patient. Immunohistochemistry revealed positive staining for beta-catenin, keratin, CD56, vimentin, and CD10 in all cases.CONCLUSION:SPT is a rarely seen pancreatic mass with low rate of malignancy. Diagnosis may be delayed due to its asymptomatic nature in most cases and a lack of descriptive symptoms. The survival rate is quite high after radical resection.

Pancreatic Tumors

“…SPTs are considered to be low-grade malignancies with very good prognosis (Crocoli et al 2019;Ozcan et al 2018;Jaksic et al 1992;Shorter et al 2002;Perez et al 2009). Histologically, these tumors are extremely difficult to characterize.…”

25452 Numarali Gümrük Defteri̇ne Göre Ki̇li̇ Nezareti̇ Gümrüğü

“…48 Görüldüğü gibi I. Murad döneminde kurulan Yeniçeri Ocağına asker sağlamak için uygulanan pençik sistemi ile devşirme sistemi birbiriyle yakından alakalıdır. 49 Burada İslam devletlerinde ve Osmanlı Devleti'nde var olan kölelik ve köle ticareti meselesinin açıklanması, konunun daha iyi anlaşılması bakımından oldukça önemlidir. Halil İnalcık kölelik ve köle temini meselesini şu ifadelerle açıklamaktadır "İslam ülkelerinde, özellikle de Osmanlı toplumunda köleler hayatın vazgeçilmez bir parçasıydı.…”

Laparoscopic enucleation of Frantz's tumor of the pancreas: Case report and literature review

“…Ultrasonography (USG) of the abdomen is the initial diagnostic method; nevertheless, computerized tomography (CT) and magnetic resonance imaging (MRI) of the abdomen are much more precise and superior methods. Frequently, CT and MRI can indicate the presence of a mass in the pancreas, which has the characteristics of cystic degeneration, bleeding within the cyst, and the presence of a capsule [ 3 ]. Differential diagnoses include pancreatic ductal adenocarcinoma, cystadenoma, cystadenocarcinoma, or a pancreatic neuroendocrine tumor [ 4 ].…”