Evaluation of Children with Crimean-Congo Hemorrhagic Fever in the Central Blacksea Region

Belet, Nurşen; Top, Ayşe; Terzi, Özlem; Arslan, Hatice Nilden; Baysal, Kemal; Şensoy, Gülnar

doi:10.1097/inf.0000000000000281

Cited by 19 publications

(19 citation statements)

References 21 publications

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“…These data suggest that CCHF in children has a milder course than in adults. [8][9][10][11][12] Although the pathogenesis of CCHF has not been well-defined, inflammatory processes and release of proinflamatory cytokines such as interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-α were reported to be important factors in disease pathogenesis and disease course in viral hemorrhagic fever. [13][14][15] In this study, the relationship between cytokine values and the course of CCHF in pediatric patients is evaluated.…”

mentioning

confidence: 99%

Cytokine Concentrations In Pediatric Patients With Crimean-Congo Hemorrhagic Fever

Tezer

Özkaya-Parlakay

Kızılgün

et al. 2014

Pediatric Infectious Disease Journal

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Crimean-Congo hemorrhagic fever is a zoonotic disease that can be a severe illness in humans. We investigated concentrations of interleukin (IL)-6, tumor necrosis factor-α and IL-10 in serum samples obtained from 25 pediatric Crimean-Congo hemorrhagic fever cases and 35 control children with no signs of infection. Lower cytokine values in our patients could be a good prognostic factor to for a better outcome.

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mentioning

confidence: 99%

Cytokine Concentrations In Pediatric Patients With Crimean-Congo Hemorrhagic Fever

Tezer

Özkaya-Parlakay

Kızılgün

et al. 2014

Pediatric Infectious Disease Journal

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Section: Crimean-congo Hemorrhagic Fevermentioning

confidence: 86%

“…The disease seems to be milder in children than adults (Tezer et al 2010;Tuygun et al 2012;Belet et al 2014). A total case-fatality rate of 1.1 % (2 deaths out of 179 recorded cases in patients under the age of 18 years) in Turkey (Belet et al 2014) supports this notion. In contrast, in an Iranian study, the casefatality rate for patients under 18 years of age (with 13 males out of 14 total cases) was 26 % (Sharifi- Mood et al 2008), indicating that high case-fatality rates can occur also in younger age groups.…”

Section: Crimean-congo Hemorrhagic Fevermentioning

confidence: 86%

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Sex and Gender Differences in Infection and Treatments for Infectious Diseases

Klein

Roberts

2015

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This book provides an overview of the underlying sex-based and hormone-based differences in immunity, wound healing and pharmacokinetics, while also exploring how pregnancy affects immunity. The second part of the book shows, for the first time in a single volume, the growing number of infectious diseases for which sex and gender differences are noted, identifies common as well as distinct mechanisms mediating these differences and illustrates how responses to treatments might differ between the sexes. The awareness that males and females differ in their response to specific pathogens as well as to treatments for infectious diseases may yield sex-specific personalized treatments. This book will be of interest to basic scientists and clinicians in the fields of microbiology, immunology and pharmacology. Individuals working in academia, government and industry will also benefit from the information presented

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“…Because it can take considerable time from suspecting the diagnosis of CCHF in hospital until reaching a definitive diagnosis in the laboratory, the clinical symptoms and signs may be supportive of a primary diagnosis of the disease. Clinical features of CCHF have been evaluated and reported in several studies (TABLE 1) [20][21][22][23][24][25][26]. The clinical course of CCHF among children seems to be milder than in adults [20][21][22][23][24][25][26][27][28].…”

Section: Clinical and Epidemiological Diagnosismentioning

confidence: 97%

Diagnosis of Crimean-Congo hemorrhagic fever

Tezer

Polat²

2015

Expert Review of Anti-infective Therapy

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Crimean-Congo hemorrhagic fever (CCHF) virus is the most extensive tick-borne virus, it causes a severe infection, which occurs widely in Africa, Eastern Europe and Asia. In recent years, the dramatic increase in the global distribution of CCHF, with the high mortality rates, highlights the importance of improving diagnostic capacity. Clinical and epidemiological data play a crucial role for early recognition of CCHF. However, CCHF is clinically difficult to diagnose and to distinguish, a rapid and reliable laboratory confirmation is necessary. Confirmation of infection in the acute phase of the disease can be made by detection of viral nucleic acid using reverse transcription-PCR, by demonstration of viral antigen or by virus isolation. In the convalescent phase of the disease, the diagnosis is confirmed by demonstration of an antibody response. The consideration of viral replication kinetics and antiviral humoral immune responses facilitates the selection of appropriate laboratory tests and accurate interpretation of laboratory findings.

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Evaluation of Children with Crimean-Congo Hemorrhagic Fever in the Central Blacksea Region

Abstract: This study reports the largest series of children with CCHF and the first to describe bradycardia associated with ribavirin therapy.

Cited by 19 publications

References 21 publications

Cytokine Concentrations In Pediatric Patients With Crimean-Congo Hemorrhagic Fever

Cytokine Concentrations In Pediatric Patients With Crimean-Congo Hemorrhagic Fever

Sex and Gender Differences in Infection and Treatments for Infectious Diseases

Diagnosis of Crimean-Congo hemorrhagic fever

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