Evaluation of chondral repair using quantitative MRI

Nieminen, Miika T.; Nissi, Mikko J.; Mattila, Lauri; Kiviranta, Ilkka

doi:10.1002/jmri.23644

Cited by 36 publications

(55 citation statements)

References 128 publications

(166 reference statements)

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“…The impacts were analyzed at four acceleration levels according to the multiples of acceleration of gravity (g): low (0.3-2.4 g), moderate (2.5-3.8 g), high (3.9-5.3 g), and very high (5.4-9.8 g), where g ¼ 9.81 m/s 2 and 0 g is equated to standing still. (24) The maximum heart rate values were collected with monitors (Polar F6; Polar Electro Oy, Kempele, Finland) and the rate of perceived exertion (RPE) using the Borg scale (range, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. (25) …”

Section: Assessment Of Exercise Loadingmentioning

confidence: 99%

Effects of High-Impact Training on Bone and Articular Cartilage: 12-Month Randomized Controlled Quantitative MRI Study

Multanen

Nieminen

Häkkinen

et al. 2013

Journal of Bone and Mineral Research

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Osteoarthritis and osteoporosis often coexist in postmenopausal women. The simultaneous effect of bone-favorable high-impact training on these diseases is not well understood and is a topic of controversy. We evaluated the effects of high-impact exercise on bone mineral content (BMC) and the estimated biochemical composition of knee cartilage in postmenopausal women with mild knee osteoarthritis. Eighty women aged 50 to 66 years with mild knee osteoarthritis were randomly assigned to undergo supervised progressive exercise three times a week for 12 months (n ¼ 40) or to a nonintervention control group (n ¼ 40). BMC of the femoral neck, trochanter, and lumbar spine was measured by dual-energy X-ray absorptiometry (DXA). The biochemical composition of cartilage was estimated using delayed gadolinium-enhanced magnetic resonance imaging (MRI) cartilage (dGEMRIC), sensitive to cartilage glycosaminoglycan content, and transverse relaxation time (T2) mapping that is sensitive to the properties of the collagen network. In addition, we evaluated clinically important symptoms and physical performance-related risk factors of falling: cardiorespiratory fitness, dynamic balance, maximal isometric knee extension and flexion forces, and leg power. Thirty-six trainees and 40 controls completed the study. The mean gain in femoral neck BMC in the exercise group was 0.6% (95% CI, -0.2% to 1.4%) and the mean loss in the control group was -1.2% (95% CI, -2.1% to -0.4%). The change in baseline, body mass, and adjusted body mass change in BMC between the groups was significant (p ¼ 0.005), whereas no changes occurred in the biochemical composition of the cartilage, as investigated by MRI. Balance, muscle force, and cardiorespiratory fitness improved significantly more (3% to 11%) in the exercise group than in the control group. Progressively implemented high-impact training, which increased bone mass, did not affect the biochemical composition of cartilage and may be feasible in the prevention of osteoporosis and physical performance-related risk factors of falling in postmenopausal women.

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Section: Assessment Of Exercise Loadingmentioning

confidence: 99%

Effects of High-Impact Training on Bone and Articular Cartilage: 12-Month Randomized Controlled Quantitative MRI Study

Multanen

Nieminen

Häkkinen

et al. 2013

Journal of Bone and Mineral Research

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“…Thus, this technique might be utilized to image failure of vascular supply associated with OC. Relaxometry, a quantitative parametric MRI technique, is another method increasingly applied in the evaluation of cartilage[16, 17]. T1ρ and adiabatic T1ρ, two of these quantitative parameters, have received attention lately due to their sensitivity to changes in cartilage proteoglycan content[18-23].…”

Section: Introductionmentioning

confidence: 99%

Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis

Tóth

Nissi

Wang

et al. 2015

Osteoarthritis and Cartilage

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Objective Identify and interrupt the vascular supply to portions of the distal femoral articularepiphyseal cartilage complex (AECC) in goat kids to induce cartilage necrosis, characteristic of early lesions of osteochondrosis; then utilize MRI to identify necrotic areas of cartilage. Design Distal femora were perfused and cleared in goat kids of various ages to visualize the vascular supply to the distal femoral AECC. Vessels located on the axial aspect of the medial femoral condyle and on the abaxial side of the lateral trochlear ridge were transected in eight 4-day-old goats to induce cartilage necrosis. Goats were euthanized 1, 2, 3, 4, 5, 6, 9, and 10 weeks post operatively and operated stifles were harvested. Adiabatic T1ρ relaxation time maps of the harvested distal femora were generated using a 9.4T MR scanner, after which samples were evaluated histologically. Results Interruption of the vascular supply to the medial femoral condyle caused lesions of cartilage necrosis in 6/8 goat kids that were demonstrated histologically. Adiabatic T1ρ relaxation time mapping identified these areas of cartilage necrosis in 5/6 cases. No significant findings were detected after transection of perichondrial vessels supplying the lateral trochlear ridge. Conclusions Cartilage necrosis, characteristic of early osteochondrosis, can be induced by interrupting the vascular supply to the distal femoral AECC in goat kids. The ability of high field MRI to identify these areas of cartilage necrosis in the AECC using the adiabatic T1ρ sequence suggests that this technique may be useful in the future for the early diagnosis of osteochondrosis.

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“…If cartilage defects have occurred, focal defects may be treated by different surgical cartilage repair techniques, including microfracture (Mfx), osteochondral autograft transplantations (OAT), and autologous chondrocyte implantation (ACI) or matrix associated ACI (MACI), respectively [36–39]. These techniques are known to result in different histological types of cartilage repair tissue [40–43].…”

Section: Introductionmentioning

confidence: 99%

Cartilage Repair Surgery: Outcome Evaluation by Using Noninvasive Cartilage Biomarkers Based on Quantitative MRI Techniques?

Jungmann

Baum

Bauer

et al. 2014

BioMed Research International

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Background. New quantitative magnetic resonance imaging (MRI) techniques are increasingly applied as outcome measures after cartilage repair. Objective. To review the current literature on the use of quantitative MRI biomarkers for evaluation of cartilage repair at the knee and ankle. Methods. Using PubMed literature research, studies on biochemical, quantitative MR imaging of cartilage repair were identified and reviewed. Results. Quantitative MR biomarkers detect early degeneration of articular cartilage, mainly represented by an increasing water content, collagen disruption, and proteoglycan loss. Recently, feasibility of biochemical MR imaging of cartilage repair tissue and surrounding cartilage was demonstrated. Ultrastructural properties of the tissue after different repair procedures resulted in differences in imaging characteristics. T2 mapping, T1rho mapping, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), and diffusion weighted imaging (DWI) are applicable on most clinical 1.5 T and 3 T MR scanners. Currently, a standard of reference is difficult to define and knowledge is limited concerning correlation of clinical and MR findings. The lack of histological correlations complicates the identification of the exact tissue composition. Conclusions. A multimodal approach combining several quantitative MRI techniques in addition to morphological and clinical evaluation might be promising. Further investigations are required to demonstrate the potential for outcome evaluation after cartilage repair.

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Evaluation of chondral repair using quantitative MRI

Cited by 36 publications

References 128 publications

Effects of High-Impact Training on Bone and Articular Cartilage: 12-Month Randomized Controlled Quantitative MRI Study

Effects of High-Impact Training on Bone and Articular Cartilage: 12-Month Randomized Controlled Quantitative MRI Study

Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis

Cartilage Repair Surgery: Outcome Evaluation by Using Noninvasive Cartilage Biomarkers Based on Quantitative MRI Techniques?

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