Evaluation of choroidal lesions with swept-source optical coherence tomography

Ung, Cindy; Silverman, Rebecca; Woods, Russell L.; Lane, Anne Marie; Papakostas, Thanos D.; Husain, Deeba; Miller, Joan W.; Gragoudas, Evangelos S.; Kim, Ivana K.

doi:10.1136/bjophthalmol-2017-311586

Cited by 8 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Swept-source OCT (SS-OCT) provides greater tissue depth resolution using a 1,050 nm wavelength laser source and has been shown to enhance imaging of the choroido-scleral interface [11]. Morphological features of choroidal melanocytic lesions can be evaluated in more detail with SS-OCT than EDI-OCT; however, thickness measurements compared to US measurements have not been robustly studied [12, 13]. In the future, SS-OCT may become more widespread, warranting further study of this modality in evaluating choroidal melanocytic tumours in relation to the MOLES thickness score.…”

Section: Discussionmentioning

confidence: 99%

Is Tumour Thickness Measurement Required for MOLES Scoring of Melanocytic Choroidal Tumours?

et al. 2023

View full text Add to dashboard Cite

Introduction: It can be challenging to distinguish between choroidal naevi and melanomas in the community setting, particularly without access to ultrasonography, required to measure the thickness of melanocytic choroidal tumours. We aimed to determine whether thickness measurement is required for MOLES scoring of melanocytic choroidal tumours. Methods: The dataset of a recent MOLES evaluation was reviewed. Patients were selected for the present study if their MOLES tumour size category was determined by tumour thickness measured with ultrasonography (US). The largest basal tumour diameter and tumour thickness were then measured from ultra-widefield fundus images and optical coherence tomography (OCT) images, respectively. Results: The tumour size category was determined by tumour diameter in 203/222 (91.4%) with no influence of tumour thickness. The tumour thickness influenced the MOLES score in 19/222 (8.6%) patients. In 11/19 patients with OCT measurements of tumour thickness, the US measurement exceeded the OCT by more than 25% in 5 patients, more than 50% in 2 patients and more than 75% in 1 patient. As a result, the revised tumour thickness based on OCT determined the size category in 4/216 (1.8%) patients. The Optos measurements increased the diameter score by 1 in 5 patients. As a result, the revised tumour thickness determined the size category in 4/216 (1.8%) patients. If both the revised diameter and thickness scores were considered, the MOLES score reduced in 4 patients. If both the diameter and thickness scores were considered, the MOLES score reduced in 5 and increased in 1. Only 0.94% (2/211) of melanocytic choroidal tumours assessed with MOLES when using Optos ultra-widefield fundus images diameter and OCT to measure tumour diameter and thickness, respectively, required a change in management from a reduction in MOLES score from 1 to 0. Discussion/Conclusion: This study suggests that the MOLES category for size is influenced more by the tumour diameter, if it can be measured accurately, than by the thickness. This study suggests ignoring tumour thickness if this cannot be measured accurately with OCT, unless the tumour has a mushroom shape.

show abstract

Section: Discussionmentioning

confidence: 99%

Is Tumour Thickness Measurement Required for MOLES Scoring of Melanocytic Choroidal Tumours?

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The Swept Source OCT device (SS-OCT) from Zeiss (Plex Elite 9000, Carl Zeiss Meditec, Dublin, CA) is capable of capturing the mid-peripheral retinal structures with an optical resolution of approx. 6 µm (digital 2 µm) (100,000 A-scans per second); however, it is still not able to depict the outer periphery of the retina due to the scan geometry [36].…”

Section: Technologymentioning

confidence: 99%

“…Das Swept-Source-OCT-Gerät (SS-OCT) der Firma Zeiss (Plex Elite 9000, Carl Zeiss Meditec, Dublin, CA) ist in der Lage, die retinalen Strukturen der mittleren Peripherie bei einer optischen Auflösung von ca. 6 µm (digital 2 µm) zu erreichen (100 000 A-Scans/s); die äußere Netzhautperipherie allerdings ist auch hier aufgrund der Scangeometrie nicht darstellbar [36].…”

Section: Technologieunclassified

Retinale und choroidale Ultra-Weitwinkel-OCT – Technologie, Einblicke und klinische Bedeutung

Brockmann

Dera

et al. 2022

Klin Monbl Augenheilkd

View full text Add to dashboard Cite

ZusammenfassungDie Ultra-Weitwinkel optische Kohärenztomografie (UWF-OCT) bietet als eine der modernsten Verfahren der retinalen und choroidalen Bildgebung einen deutlichen Zugewinn an Informationen hinsichtlich peripherer Netzhautläsionen und deren Differenzialdiagnosen. Insbesondere das Vorliegen minimaler Ansammlungen subretinaler Flüssigkeit kann damit detailliert beurteilt und im Verlauf dokumentiert werden. Auch die choroidale Ausdehnung von Aderhautläsionen kann exakt vermessen werden. Die Limitationen in der Anwendung beschränken sich ähnlich wie bei der bisherigen OCT nach wie vor auf die Trübung optischer Medien und die Compliance des Patienten. Die Weite der Pupille spielt hier eine eher untergeordnete Rolle, die Qualität der Aufnahmen ist jedoch in medikamentöser Mydriasis besser. Zusammen mit der UWF-Fundusfotografie ist die UWF-OCT ein hilfreiches Tool in der Beurteilung und Kontrolle peripherer Netzhaut- und Aderhautläsionen.

show abstract

“…In particular, this method can show whether the choroidal melanoma surface is regular and lobular ( 43 ), whether it exhibits normal retinal thickness and a complete photoreceptor cell layer, and whether extensive retinal detachment and “debris” are present in the dorsal retina ( 19 ). Swept-source OCT can show fine details of the choroid near the fovea and posterior pole ( 44 ). Furthermore spectral domain OCT can help to observe lesions in the pigment epithelium ( 45 ).…”

Section: Diagnosis Of Choroid Melanomamentioning

confidence: 99%

Application of Multimodal and Molecular Imaging Techniques in the Detection of Choroidal Melanomas

Wang

Zhang

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

Choroidal melanomas are the most common ocular malignant tumors worldwide. The onset of such tumors is insidious, such that affected patients often have no pain or obvious discomfort during early stages. Notably, enucleation is required for patients with a severe choroidal melanoma, which can seriously impact their quality of life. Moreover, choroidal melanomas metastasize early, often to the liver; this eventually causes affected patients to die of liver failure. Therefore, early diagnosis of choroidal melanomas is extremely important. Unfortunately, an early choroidal melanoma is easily confused with a choroidal nevus, which is the most common benign tumor of the eye and does not often require surgical treatment. This review discusses recent advances in the use of multimodal and molecular imaging to identify choroidal melanomas and choroidal nevi, detect early metastasis, and diagnose patients with choroidal melanomas.

show abstract

Evaluation of choroidal lesions with swept-source optical coherence tomography

Abstract: SS-OCT is useful in imaging most choroidal melanocytic lesions. Image quality is best when the choroidal lesion is closer to the fovea, has a smaller diameter and a lighter choroidal pigmentation.

Cited by 8 publications

References 18 publications

Is Tumour Thickness Measurement Required for MOLES Scoring of Melanocytic Choroidal Tumours?

Is Tumour Thickness Measurement Required for MOLES Scoring of Melanocytic Choroidal Tumours?

Retinale und choroidale Ultra-Weitwinkel-OCT – Technologie, Einblicke und klinische Bedeutung

Application of Multimodal and Molecular Imaging Techniques in the Detection of Choroidal Melanomas

Contact Info

Product

Resources

About