Evaluation of chronological changes in bone fractures and age-related bone loss: A test case from Poland

Spinek, Anna; Lorkiewicz, Wiesław; Mietlińska, Joanna; Sewerynek, Ewa; Kłys, Arkadiusz; Caramelli, David; Żądzińska, Elżbieta

doi:10.1016/j.jas.2016.06.007

Cited by 11 publications

(7 citation statements)

References 66 publications

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“…This technique is commonly used for estimating of BMD of skeletal remains [ 16 ]. To compensate for the lack of soft tissues, the bones are placed in, for instance, dry rice [ 17 , 18 ]. In this study, radial bones were put in a container filled with rice at a depth of 3–4 cm.…”

Section: Methodsmentioning

confidence: 99%

Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials

et al. 2018

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The relation of LCT-13910 genotypes and bone mineral density (BMD) has been the subject of modern-day human population studies, giving inconsistent results. In the present study we analyze for the first time a relation of LCT-13910 genotypes and BMD in historical skeletal individuals. Ancient population might be a model for testing this association due to elimination of non-natural factors affecting bone density. Among 22 medieval individuals from Sanok churchyard (South-Eastern Poland; dated from XIV to XVII c. AD) we identified 4 individuals with osteoporosis (mean BMD = 0.468 g/cm2, SD = 0.090), 10 individuals with osteopenia (mean BMD = 0.531 g/cm2, SD = 0.066) and 8 individuals with normal BMD values (mean BMD = 0,642 g/cm2, SD = 0.060). Analyses of BMD and LCT-13910 genotypes revealed that mean BMD was the highest (0.583 g/cm2, SD = 0.065) in the individuals with lactose tolerance genotypes (TT and CT). We also found possible association of lower BMD at the radius and CC genotypes due to higher but not statistically significant frequency of osteoporosis in the lactose intolerant group (p = 0.60). Statistically significant correlation was found between BMD and females aged 20–35 years, with tendency to reduce BMD with age (p = 0.02).

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Section: Methodsmentioning

confidence: 99%

Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials

et al. 2018

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“…However, in terms of fracture incidence in old age, the risk may have been lower in earlier human populations than in modern, more sedentary populations. Bone loss with ageing is well documented in early historic and archaeological human skeletal samples [48–52]; however, evidence for age-related fractures in samples prior to the past few 100 years is relatively rare [10,49,69,70] (although see [50]). This may be partly a function of difficulty in recognizing such fractures, along with reduced average lifespans [10,69], but it may also result from the development of more advantageous bone structural properties prior to middle and old age (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…This may be partly a function of difficulty in recognizing such fractures, along with reduced average lifespans [10,69], but it may also result from the development of more advantageous bone structural properties prior to middle and old age (e.g. see [70]). The importance of achieving a high peak bone mass (or strength) early in adulthood, in order to prepare for losses later in life, has been emphasized by many researchers (e.g.…”

Section: Discussionmentioning

confidence: 99%

Skeletal ageing in Virunga mountain gorillas

Ruff

Junno

Eckardt

et al. 2020

Phil. Trans. R. Soc. B

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Bone loss and heightened fracture risk are common conditions associated with ageing in modern human populations and have been attributed to both hormonal and other metabolic and behavioural changes. To what extent these age-related trends are specific to modern humans or generally characteristic of natural populations of other taxa is not clear. In this study, we use computed tomography to examine age changes in long bone and vertebral structural properties of 34 wild-adult Virunga mountain gorillas ( Gorilla beringei beringei ) whose skeletons were recovered from natural accumulations. Chronological ages were known or estimated from sample-specific dental wear formulae and ranged between 11 and 43 years. Gorillas show some of the same characteristics of skeletal ageing as modern humans, including endosteal and some periosteal expansion. However, unlike in humans, there is no decline in cortical or trabecular bone density, or in combined geometric-density measures of strength, nor do females show accelerated bone loss later in life. We attribute these differences to the lack of an extended post-reproductive period in gorillas, which provides protection against bone resorption. Increases in age-related fractures (osteoporosis) in modern humans may be a combined effect of an extended lifespan and lower activity levels earlier in life. This article is part of the theme issue ‘Evolution of the primate ageing process'.

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“…There are evidences implying that, even in bones with some form of diagenetic change, bone mineral content is marginally altered . Recently, Spinek et al conducted a Fourier transform infrared spectrometry analysis in femora from various archeological sites and chronologies (including a Neolithic sample [4600–4000 BCE]) that indicated a good state of preservation, with no diagenetic alterations. A set of direct—macroscopical analysis, absence of soil erosion on plain radiographs and microradiography —and indirect—the pattern of bone loss is epidemiologically expected —evidences suggest that the sample from the CISC is also in good state of preservation.…”

Section: Discussionmentioning

confidence: 99%

DXAGE: A New Method for Age at Death Estimation Based on Femoral Bone Mineral Density and Artificial Neural Networks

Navega

Coelho

Cunha

et al. 2017

Journal of Forensic Sciences

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Age at death estimation in adult skeletons is hampered, among others, by the unremarkable correlation of bone estimators with chronological age, implementation of inappropriate statistical techniques, observer error, and skeletal incompleteness or destruction. Therefore, it is beneficial to consider alternative methods to assess age at death in adult skeletons. The decrease in bone mineral density with age was explored to generate a method to assess age at death in human remains. A connectionist computational approach, artificial neural networks, was employed to model femur densitometry data gathered in 100 female individuals from the Coimbra Identified Skeletal Collection. Bone mineral density declines consistently with age and the method performs appropriately, with mean absolute differences between known and predicted age ranging from 9.19 to 13.49 years. The proposed method-DXAGE-was implemented online to streamline age estimation. This preliminary study highlights the value of densitometry to assess age at death in human remains.

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Evaluation of chronological changes in bone fractures and age-related bone loss: A test case from Poland

Cited by 11 publications

References 66 publications

Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials

Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials

Skeletal ageing in Virunga mountain gorillas

DXAGE: A New Method for Age at Death Estimation Based on Femoral Bone Mineral Density and Artificial Neural Networks

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