Evaluation of circulating galanin levels after exercise-induced pituitary hormone secretion in man

Ceresini, Graziano; Marchini, Leonardo; Fabbo, Andrea; Freddi, M.; Pasolini, G.; Reali, N; Troglio, G.; Valenti, Giorgio

doi:10.1016/s0026-0495(97)90254-7

Cited by 17 publications

(9 citation statements)

References 27 publications

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“…Studies on female rats with an altered galanin gene have confirmed that proliferation of lactotrophs under a high dose of oestrogen can be completely abolished (Wynick et al, 1998b), but galanin has also been associated with many other pituitary functions, such as the release of GH or LH, FSH and ACTH in humans. For further reading, we recommend the following references (Vrontakis et al, 1989(Vrontakis et al, , 1996Gabriel et al, 1989Gabriel et al, , 1990Calvo et al, 1990;Hooi et al, 1990aHooi et al, , 1997O'Halloran et al, 1991;Hyde and Howard, 1992;Niimi et al, 1993;Moore et al, 1994;Giustina et al, 1994;Hyde et al, 1996Hyde et al, , 1998Sauer-Ramirez et al, 1996;Hammond et al, 1997;Ceresini et al, 1997;Cai et al, 1998;Todd et al, 1998;Baranowska et al, 1999;Ren et al, 1999;Shen et al, 1999;Zdrojewicz and Sowinska, 2000;Elsaesser, 2001). This is in agreement with the presence of galanin in all pituitary cells during development; they all express galanin which, in the adult, may potentially activate specific functions in specific endocrine cells of the pituitary.…”

Section: Discussionsupporting

confidence: 65%

Neuropeptides in anterior pituitary development

Cimini

2003

Intl J of Devlp Neuroscience

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Recent studies using biotechnological methods have achieved significant advances in our knowledge of molecular mechanisms underlying pituitary gland development and the differentiation of pituitary cytotypes. A large number of neuropeptides have been reported in the adult pituitary gland as well as in the central and peripheral nervous system. The early presence of neuropeptides during pituitary development is reviewed here. Neuromedin U (NmU), galanin and the polypeptide 7B2 have been localised to different endocrine cells of the gland. Their expression seems to be manifold even though it is temporally and spatially regulated. There is now firm immunocytochemical evidence that neuropeptides are present during morphogenesis of the pituitary and can be present simultaneously with all pituitary hormones.

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Section: Discussionsupporting

confidence: 65%

Neuropeptides in anterior pituitary development

Cimini

2003

Intl J of Devlp Neuroscience

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“…However, exercise alone seems not to be sufficient to increase plasma galanin levels in rats, and the effect also requires glucose (Milot and Trudeau, 1997). Data on the influence of exercise on plasma galanin levels in humans are scarce and inconclusive, with both an increase in plasma galanin levels and no change after exercise being reported (Ceresini et al, 1997;Legakis et al, 2000).…”

Section: A Glucose Metabolism and Diabetesmentioning

confidence: 99%

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

et al. 2014

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“…Our results demonstrate that plasma galanin is not increased despite considerable elevation of plasma ACTH in Addison ' s disease. Previous studies have shown that neither stimulation of ACTH by acute physical exercise [38,39] nor CRH and / or desmopressin administration [40] infl uenced plasma galanin levels. In contrast, a recent study has shown dramatic increase in plasma galanin after severe orthostatic stress [41] .…”

Section: Discussionmentioning

confidence: 92%

Plasma Galanin, Vasopressin, and Oxytocin in Patients with Addison's Disease

Grenbäck¹,

Al²,

Bucht³

et al. 2007

Horm Metab Res

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Galanin is colocalized with adrenocorticotrophin (ACTH) in the human pituitary and with corticotrophin releasing hormone, arginine, vasopressin, and oxytocin in the hypothalamus. Galanin, vasopressin, and oxytocin influence the secretion of pituitary ACTH. The aim of this study was to investigate if the endogenous stimulation of ACTH release in Addison's disease was reflected in plasma galanin, vasopressin, and oxytocin. ACTH, galanin, vasopressin, and oxytocin were measured in plasma from 14 patients with Addison's disease, one patient with Nelson's syndrome, and 14 healthy controls. Eight patients had elevated plasma ACTH whereas six patients and all controls had ACTH levels within the reference-range. There was no difference in galanin or vasopressin between patients and controls or between samples with low or high ACTH concentrations. In contrast, oxytocin was higher in patients with elevated plasma ACTH compared to patients and controls with normal or low ACTH. No relation was found between galanin or oxytocin and age or sex. A tendency towards lower vasopressin with increasing age was found among the men (p=0.057). The highest ACTH and galanin levels were found in the patient with Nelson's syndrome. In conclusion, increased plasma ACTH was not reflected in elevated plasma galanin or vasopressin. In contrast, elevated ACTH levels were accompanied by higher oxytocin levels.

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Evaluation of circulating galanin levels after exercise-induced pituitary hormone secretion in man

Cited by 17 publications

References 27 publications

Neuropeptides in anterior pituitary development

Neuropeptides in anterior pituitary development

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

Plasma Galanin, Vasopressin, and Oxytocin in Patients with Addison's Disease

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