The potentials of Chemical (acid) and Biological (Aspergillus niger and Rhizopus oryzae) hydrolysis on some agricultural wastes, namely: peels from ripe plantain (RPP), unripe plantain (UPP), red cocoyam (RCP), white cocoyam (WCP), yam (YP), cassava (CP) and garri processing chaff (GPC) into beneficial by products (Ethanol, Single Cell Protein and Vinegar) were investigated using standard methods. Glucose yield ranged from 4.68-17.24mg/g, 2.41-13.84mg/g and 1.28-5.22mg/g for A. niger R. oryzae and Acid hydrolysis of the various wastes. Inoculating the hydrolysates with Saccharomyces cerevisiae yielded significant (p < 0.05) amount of ethanol after 120hrs, with significant (p < 0.05) reduction in glucose contents. Ethanol contents ranged from 3.82-6.89%, 3.74-6.44% and 3.28-6.25%, while the amount of single cell protein (SCP) obtained from the biomass after ethanol fermentation ranged from 9.10-15.80%, 7.50-13.11% and 6.00-10.20% for A. niger, R. oryzae and Acid hydrolysates respectively. The vinegar obtained after seven days fermentation of the alcoholic product had acetic acid concentrations ranging from 0.14-1.10%, 0.13-0.99% and 0.11-0.95% for A. niger, R. oryzae and acid treatments respectively. This study has shown usefulness of microbial methods of hydrolysis over the chemical treatment method, for improved yield of fermentation by products.