Evaluation of Clinical, Macroscopic, and Histopathologic Response to Treatment in Nonhypoproteinemic Dogs with Lymphocytic‐Plasmacytic Enteritis

García-Sancho, Mercedes; Rodríguez-Franco, Fernando; Sainz, Á.; Mancho, Carolina; Rodríguez, A.

doi:10.1111/j.1939-1676.2007.tb02922.x

Cited by 64 publications

(39 citation statements)

References 20 publications

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“…Over the past 2 decades, several independent groups have developed and applied classification systems for characterizing the nature and severity of gastrointestinal inflammatory changes. 4,[9][10][11][12][13]17,[20][21][22][23][24][25][26][27][28][29][30][31][32][33] In most of these studies, the nature of gastrointestinal inflammation is portrayed primarily by the dominant population of inflammatory cells (eg, lymphoplasmacytic, eosinophilic, pyogranulomatous) within the lamina propria. Such populations, however, may overlap and occur in various combinations and patterns.…”

Section: Limitations Of Histopathologymentioning

confidence: 99%

Endoscopic, Biopsy, and Histopathologic Guidelines for the Evaluation of Gastrointestinal Inflammation in Companion Animals

Washabau

Day

Willard

et al. 2010

Veterinary Internal Medicne

320

273

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Section: Limitations Of Histopathologymentioning

confidence: 99%

Endoscopic, Biopsy, and Histopathologic Guidelines for the Evaluation of Gastrointestinal Inflammation in Companion Animals

Washabau

Day

Willard

et al. 2010

Veterinary Internal Medicne

320

273

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“…Although metronidazole and/or prednisolone are widely used for the treatment of canine CE, little information regarding their effects on GI microbiota have been reported [15], [17]. Thus, this study was performed to provide basic information on the effects of these drugs on GI microbiota using single breed dogs, and controlling for diet and environment.…”

Section: Discussionmentioning

confidence: 99%

“…However, non-specific dysbiosis has been reported in chronic enteropathy (CE) [9]–[13]. Canine CE is commonly treated with dietary management, antibiotics (including metronidazole and tylosin), corticosteroid drugs, or combination of aforementioned treatments [14]–[17]. The disorder is subsequently diagnosed as food-responsive enteropathy (FRE), antibiotics-responsive enteropathy (ARE), or IBD, based on the response to treatment [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Oral Administration of Metronidazole or Prednisolone on Fecal Microbiota in Dogs

et al. 2014

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Gastrointestinal microbiota have been implicated in the pathogenesis of various gastrointestinal disorders in dogs, including acute diarrhea and chronic enteropathy. Metronidazole and prednisolone are commonly prescribed for the treatment of these diseases; however, their effects on gastrointestinal microbiota have not been investigated. The objective of this study was to evaluate the effects of these drugs on the gastrointestinal microbiota of dogs. Metronidazole was administered twice daily at 12.5 mg/kg to a group of five healthy dogs, and prednisolone at 1.0 mg/kg daily to a second group of five healthy dogs for 14 days. Fecal samples were collected before and after administration (day 0 and 14), and 14 and 28 days after cessation (day 28 and 42). DNA was extracted, and the bacterial diversity and composition of each sample were determined based on 16S ribosomal RNA (rRNA) gene sequences using next-generation sequencing (Illumina MiSeq). In the group administered metronidazole, bacterial diversity indices significantly decreased at day 14, and recovered after the cessation. Principal coordinates analysis and hierarchical dendrogram construction based on unweighted and weighted UniFrac distance matrices revealed that bacterial composition was also significantly altered by metronidazole at day 14 compared with the other time points. The proportions of Bacteroidaceae, Clostridiaceae, Fusobacteriaceae, Lachnospiraceae, Ruminococcaceae, Turicibacteraceae, and Veillonellaceae decreased, while Bifidobacteriaceae, Enterobacteriaceae, Enterococcaceae, and Streptococcaceae increased at day 14 and returned to their initial proportions by day 42. Conversely, no effect of prednisolone was observed on either the bacterial diversity or composition. Reducing pathogenic bacteria such as Fusobacteria and increasing beneficial bacteria such as Bifidobacterium through the administration of metronidazole may be beneficial for promoting gastrointestinal health; however, further investigations into the effects on diseased dogs are needed.

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“…Other studies have compared Journal of Small Animal Practice • Vol 57 • November 2016 • © 2016 British Small Animal Veterinary Association histological score after clinical resolution in FRE and SRE dogs and, similarly, no significant improvement in histologic grading was found after treatment (Allenspach et al . 2007, Garcia-Sancho et al . 2007, Schreiner et al .…”

Section: Food-responsive Enteropathy In Dogs With Cementioning

confidence: 99%

Inflammatory bowel disease versus chronic enteropathy in dogs: are they one and the same?

Dandrieux

2016

J of Small Animal Practice

145

246

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The aim of this review is to discuss why "chronic enteropathy" might be a better term than "inflammatory bowel disease" in dogs, because the treatment and outcome of the disease is very different from that of inflammatory bowel disease in humans. The effect of food, antibiotics and immunosuppressant drugs on chronic enteropathy will be reviewed. New treatments under investigation will also be introduced. Although there are several studies evaluating treatment of chronic enteropathy in dogs, the quality and quantity of evidence supporting individual therapies remains scarce and more work is needed to improve management of this disease. Finally, new findings about dogs with chronic enteropathy complicated by protein-losing enteropathy will be discussed. Although prognosis for these dogs is poor, recent data might help improve their treatment.

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Evaluation of Clinical, Macroscopic, and Histopathologic Response to Treatment in Nonhypoproteinemic Dogs with Lymphocytic‐Plasmacytic Enteritis

Abstract: Treatment of nonhypoproteinemic dogs with LPE led to clinical and endoscopic improvement, but histopathologic lesions were unchanged during therapy.

Cited by 64 publications

References 20 publications

Endoscopic, Biopsy, and Histopathologic Guidelines for the Evaluation of Gastrointestinal Inflammation in Companion Animals

Endoscopic, Biopsy, and Histopathologic Guidelines for the Evaluation of Gastrointestinal Inflammation in Companion Animals

Effect of Oral Administration of Metronidazole or Prednisolone on Fecal Microbiota in Dogs

Inflammatory bowel disease versus chronic enteropathy in dogs: are they one and the same?

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