Background: Sinonasal malignancies are uncommon neoplasms with several histopathological subtypes. These malignancies have a poor prognosis, and because of the nonspecific nature of the symptoms, most patients are diagnosed late when the disease is already at an advanced stage. This is the first study to describe the prevalence and clinicopathological correlation of sinonasal malignancy in Sudan.
Objectives: This study aims to determine the prevalence and clinicopathological correlations of sinonasal malignancies among Sudanese patients, done in a cohort of patients in Khartoum state from September 2020 to September 2021.
Methods: This is a cross-sectional hospital-based study. All Ear, nose, and throat hospitals in Khartoum state, Sudan, were included. In the period from 01/09/2020 – 30/09/2021. Data were collected using structured interviews. Data were analyzed by statistical package for social sciences (SPSS).
Results: In Khartoum state, the study encompassed all patients diagnosed with sinonasal malignancies who willingly participated. Out of the consenting participants, 44 individuals were enrolled, with males constituting 61.4% of the cohort and females representing 38.6%. Noteworthy is the observation that 38.6% of the patients fell within the age range of 50-60 years old.
The estimated prevalence of sinonasal malignancies is 0.6 per 1000 individuals. Unilateral nasal obstruction emerged as the most frequent presentation (72.7%), followed by epistaxis in 56.8%. In terms of risk factors, 18.2% were identified as smokers, and 6.8% were woodworkers; however, a notable proportion (63.6%) did not exhibit any of the known risk factors.
Conclusion: The estimated prevalence of sinonasal malignancies is 0.6 per 1000 individuals. Nasal obstruction was identified as the most common presenting symptom, and decreased visual acuity emerged as the predominant ophthalmological symptom. Notably, there was a significant association between epistaxis and squamous cell carcinoma (SCC) in 15 patients, with a p-value of 0.005. Emphasizing the importance of early detection and timely treatment, these findings highlight the critical role they play in improving patient outcomes.