Evaluation of Co-Relation between BCLC Stage of HCC and Alpha-Fetoprotein Levels

Abstract

Background: One of the leading cancers worldwide is the hepatocellular carcinoma, ranked as the 6th most common cancers. Aim: To evaluate the co-relation between BCLC staging of HCC and alpha fetoprotein levels. Study design: Cross-sectional study. Methodology: Patients (n=90) of either gender irrespective of age who were diagnosed with hepatocellular carcinoma were included into the study. Clinical examination was performed and findings were noted. Eastern cooperative oncology group ECOG scoring system was used to identify the functional performance status of the patients. Hepatocellular carcinoma staging was done using the BCLC scoring system. Complete blood counts, Liver function tests (LFTS), INR, alpha fetoprotein levels, viral serology for hepatits and ultrasonography of abdomen were performed for all the patients. Data was analyzed using SPSS version 26. Results were presented as frequency and percentage. Age was presented as mean± SD. Results: Mean AFP levels were 400.7±305.4 IU/ml with a range of 8.50- 1015 IU/ml. 3(3.3%) patients were in BCLC stage 0, 23(25.6%) were in stage A, 33(36.7%) in stage B, 15(16.7%) in stage C and 16 (17.8%) in stage D. Results showed significant positive correlation between BCLC staging and AFP levels (r=o.834, p=0.001). Conclusion: It was concluded that Hep C followed by Hep B was the main cause of HCC. AFP has a significant diagnostic and prognostic value with positive co-relation with HCC. Keywords: Alpha-Fetoprotein, BCLC Staging, HCC and Liver Disease.

Hubungan Kadar Alpha Fetoprotein dengan Derajat Keparahan Karsinoma Hepatoseluler

“…18 Terdapat beberapa penelitian yang telah menunjukkan adanya hubungan antara kadar AFP dengan derajat keparahan menurut skor BCLC. Penelitian yang dilakukan di Pakistan oleh Hamayun et al 19 menunjukkan adanya korelasi positif yang bermakna antara derajat BCLC dengan KHS (r=0,834, p=0,001). Jearth et al 11 dalam penelitian yang dilaksanakan di India juga menunjukkan bahwa pasien KHS dengan derajat BCLC C/D memiliki proporsi kadar AFP yang secara bermakna lebih tinggi dibanding dengan pasien dengan derajat BCLC 0/A/B (p≤0,001).…”