Evaluation of coenzyme Q10 combined with or without N-acetyl cysteine or atorvastatin for preventing contrast-induced kidney injury in diabetic rats

Alshogran, Osama Y.; Nusair, Shreen Deeb; El‐Elimat, Tamam; Alzoubi, Karem H.; Obeidat, Abdullah; Sweidan, Maya

doi:10.1007/s00210-021-02070-w

Cited by 5 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with this finding, Alshogran et al. [ 57 ] demonstrated that pretreatment with CoQ10 (20 mg/kg, orally) and atorvastatin (10 mg/kg, orally) exhibited regenerative effects on distal tubules with mild kidney histology alterations after contrast-induced AKI. Also, a recent experimental study conducted by Couto et al.…”

Section: Protective Properties Of Coq10 In Aki Reported In Experiment...mentioning

confidence: 71%

“…2021 [ 56 ] Mice Renal ischemia–reperfusion injury 50 mg/kg, tail vein injection NA The mitochondria-targeted triphenylphosphine CoQ10 nanoparticles alleviated mtDNA damage, suppressed inflammatory and apoptotic responses, and improved renal function Alshogran et al. 2021 [ 57 ] Rats Contrast-induced kidney injury 20 mg/kg, orally Combined with 10 mg/kg atorvastatin Pretreatment with CoQ10/atorvastatin showed regenerative effect on distal tubules with mild kidney histology alterations as compared with contrast-induced nephropathy rats Couto et al. 2021 [ 58 ] Rats Contrast-induced acute kidney injury 10 mg/kg, intraperitoneally NA CoQ10 ameliorated renal function, prevented hemodynamic changes, neutralized oxidative damage, and prevented the progression of histologic damage CoQ10 coenzyme Q10, AKI acute kidney injury, iNOS inducible nitric oxide synthase, NF-κB nuclear factor-κB, PON1 paraoxonase 1, HO-1 heme oxygenase 1, ESWL extracorporeal shock wave lithotripsy, EGCG epigallocatechin gallate, MnSOD manganese superoxide dismutase, Nrf2 nuclear factor erythroid 2-related factor 2, L-NAME l -arginine analog, BUN blood urea nitrogen, SCR serum creatinine, ROS reactive oxygen species, i.p.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Zhao

Wu²,

Liao

et al. 2022

Cell Mol Biol Lett

View full text Add to dashboard Cite

Coenzyme Q10 (CoQ10), an endogenous antioxidant, has been reported frequently to exert an outstanding protective effect on multiple organ injury, including acute kidney injury (AKI). In this study, we aim to summarize all the current evidence of the protective action of CoQ10 against AKI as there are presently no relevant reviews in the literature. After a systematic search, 20 eligible studies, either clinical trials or experimental studies, were included and further reviewed. CoQ10 treatment exhibited a potent renal protective effect on various types of AKI, such as AKI induced by drugs (e.g., ochratoxin A, cisplatin, gentamicin, L-NAME, and nonsteroidal anti-inflammatory drug), extracorporeal shock wave lithotripsy (ESWL), sepsis, contrast media, and ischemia–reperfusion injury. The renal protective role of CoQ10 against AKI might be mediated by the antiperoxidative, anti-apoptotic, and anti-inflammatory potential of CoQ10. The molecular mechanisms for the protective effects of CoQ10 might be attributed to the regulation of multiple essential genes (e.g., caspase-3, p53, and PON1) and signaling cascades (e.g., Nrf2/HO-1 pathway). This review highlights that CoQ10 may be a potential strategy in the treatment of AKI.

show abstract

Section: Protective Properties Of Coq10 In Aki Reported In Experiment...mentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Zhao

Wu²,

Liao

et al. 2022

Cell Mol Biol Lett

View full text Add to dashboard Cite

show abstract

“…As a result, NAC is still commonly used in daily clinical practice as previously described [ 10 ]. Last but not least, promising results have been reported in several animal studies using NAC as either the main treatment under investigation or standard/conventional treatment (positive control) [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Apart from its antioxidant properties [ 23 ], supporting biological plausibility of efficacy relies on its vasodilatory effects [ 24 ], namely its ability to cause renal artery vasodilatation/renal blood flow increase, improving renal hemodynamics [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Renoprotective Effect of Vardenafil and Avanafil in Contrast-Induced Nephropathy: Emerging Evidence from an Animal Model

Zisis

Georgiadis

Docea

et al. 2022

JPM

View full text Add to dashboard Cite

The potential renoprotective effects of vardenafil (VAR) have been evaluated in a very limited number of studies using acute kidney injury animal models other than contrast-induced nephropathy (CIN) with promising results, while avanafil (AVA) has not been evaluated in this respect before. The purpose of this study was to evaluate for the first time the potential renoprotective effect of VAR and AVA in a rat model of CIN. Twenty-five male Wistar rats were equally assigned into five groups: control, CIN, CIN+N-acetyl cysteine (NAC) (100 mg/kg/day) as a positive control, CIN+VAR (10 mg/kg/day) and CIN+AVA (50 mg/kg/day). CIN was induced by dehydration, inhibition of prostaglandin and nitric oxide synthesis as well as exposure to the contrast medium (CM). Serum Cr (sCr) levels were measured at 24 and 48 h after CIN induction. At 48 h of CM exposure, animals were sacrificed. Matrix metalloproteinase (MMP) 2 (MMP-2) and MMP-9, kidney injury molecule 1 (KIM-1) and cystatin-C (Cys-C) were measured on renal tissue. Histopathological findings were evaluated on kidney tissue. All treatment groups had close to normal kidney appearance. sCr levels subsided in all treatment groups compared to CIN group at 48 h following CIN induction. A significant decline in the levels of MMP-2, MMP-9, KIM-1 and Cys-C compared to CIN group was observed. These results provide emerging evidence that VAR and AVA may have the potential to prevent CIN.

show abstract

Prevention of contrast induced-acute kidney injury using coenzyme Q10 in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Ahmadimoghaddam,

Talebi,

Rahmani

et al. 2023

Eur J Clin Pharmacol

View full text Add to dashboard Cite

Evaluation of coenzyme Q10 combined with or without N-acetyl cysteine or atorvastatin for preventing contrast-induced kidney injury in diabetic rats

Cited by 5 publications

References 25 publications

Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Renoprotective Effect of Vardenafil and Avanafil in Contrast-Induced Nephropathy: Emerging Evidence from an Animal Model

Prevention of contrast induced-acute kidney injury using coenzyme Q10 in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Contact Info

Product

Resources

About