Evaluation of cognitive impairment in patients with episodic migraine

Abstract

BACKGROUND AND OBJECTIVES: The purpose of this study was to evaluate the presence of cognitive deficits in patients with episodic migraine and control group, and to compare with the results previously described in the literature. METHODS: Patients with episodic migraine were included according to the International Headache Society criteria, and a control group was selected, matched by sex, age, and schooling. Patients were asked about the frequency and intensity of headaches, medications used, and comorbidities. Afterwards, a neuropsychological assessment was applied using the Montreal Cognitive Assessment, the clock drawing test, the verbal fluency test, and the Stroop test. The main variables influencing cognitive dysfunctions were analyzed (depressive disorder, anxiety disorder, sleep disorder, use of medication). RESULTS: Thirty patients with episodic migraine and 30 controls were evaluated. Patients with episodic migraine had a performance in the Montreal Cognitive Assessment test (p=0.53), the clock drawing test (p=0.80), the verbal fluency test (p=0.44) and the Stroop test (p=0.97) similar to the control group. Patients with chronic migraine (30 patients and 30 controls) performed a Montreal Cognitive Assessment test (p=0.00), verbal fluency test (p=0.00) and Stroop test (p=0.00) lower than the group control. The main variables influencing cognitive disorders were studied by linear regression, and none of these variables was an influencing factor in the Montreal Cognitive Assessment test. CONCLUSION: Patients with episodic migraine did not present cognitive deficits compared to a control group.

Ferramentas Da Biologia Molecular No Estudo Das Doenças Emergentes E Reemergentes Como a Covid-19

“…O risco de lesões apresenta-se tanto para pacientes com aura como sem aura, ocorrendo um aumento em pacientes com migrânea crônica e migrânea com aura. Estudos demonstraram efeitos cumulativos da migrânea no sistema nervoso central (SNC), embora esses resultados ainda não sejam bem esclarecidos, acredita-se que em longo prazo, as lesões provocadas pela migrânea causam déficits cognitivos (TEIXEIRA et al, 2018).…”

“…A migrânea é uma dor craniana com duração de 4 a 72 horas, definida por muita intensidade, pulsátil ou latejante, que piora durante as atividades diárias, podendo apresentar sintomas como náuseas, fotofobia, fonofobia e vômitos. Numa crise típica de migrânea podem ocorrer cinco fases detectáveis, como por exemplo, pródromo (sintomas premonitórios), cefaleia, aura, sintomas associados à dor (náuseas e fotofobia) e pósdromo (exaustão e fadiga) (TEIXEIRA et al, 2018).…”

Interictal Dysfunctions of Attention, Vigilance, and Executive Functions in Migraine and Their Reversal by Preventive Treatment: A longitudinal Controlled Study

“…[ 19 20 ] However, few clinic-based studies reported negative results. [ 18 23 24 25 ] The conflicting results may be due to the small sample size in these studies (ranging from 12 to 74), different study designs such as the inclusion of older patients,[ 23 24 25 ] recruitment of specific groups such as college students,[ 25 ] use of different cognitive test batteries,[ 24 25 ] not controlling for the proximity of the attack,[ 23 25 ] and use of different techniques of analysis of results. Most studies did not mention whether preventive medications were continued during the assessment.…”

“…[ 17 ] Studies using Montreal cognitive assessment reported positive results in discriminating migraine patients from controls,[ 26 28 29 30 ] except in one. [ 25 ] These differences suggest possible greater impairment of frontal lobe functions than other cognitive domains.…”

Teatro De Fantoches Como Ferramenta Educativa Para Promoção E Recuperação Da Saúde De Crianças

“…O risco de lesões apresenta-se tanto para pacientes com aura como sem aura, ocorrendo um aumento em pacientes com migrânea crônica e migrânea com aura. Estudos demonstraram efeitos cumulativos da migrânea no sistema nervoso central (SNC), embora esses resultados ainda não sejam bem esclarecidos, acredita-se que em longo prazo, as lesões provocadas pela migrânea causam déficits cognitivos(TEIXEIRA et al, 2018). Osmofobia e odor como gatilho de cefaleia são condições muito frequentemente associadas a migrânea.…”