Evaluation of Common Carotid Stiffness via Echo Tracking in Hypertensive Patients Complicated by Acute Aortic Dissection

Gu, Wenhui; Wu, Juan; Pei, Yongkai; Ji, Jiamei; Wu, Haibo; Wu, Jun

doi:10.1002/jum.15466

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Given the significant mortality and poor prognosis, it is crucial to find some additional parameters to identify the hypertensive (HP) individuals at high risk of AAD. Our previous study has confirmed that the biomechanical parameters such as carotid arterial stiffness could be a supplemental indicator to predict AAD 6 . Hence, we deduced that the quantitative evaluation of ascending aortic mechanical behaviors might be another potentially personalized risk parameter in HP patients.…”

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confidence: 58%

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Evaluation of Ascending Aortic Longitudinal Strain Via Two‐Dimensional Speckle Tracking Echocardiography in Hypertensive Patients Complicated by Type A Aortic Dissection

Pei

Wang

et al. 2021

J of Ultrasound Medicine

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Objective To explore the value of ascending aortic longitudinal strain (LS) in identification of hypertensive (HP) patients with a high risk of type A aortic dissection (AAD). Methods Total 40 primary HP patients with AAD (group C), 80 selected age‐ and sex‐matched primary HP patients (group A, normal‐sized ascending aorta (AA), n = 40; group B, dilated AA, n = 40) and 40 healthy volunteers were enrolled in this study. Brachial blood pressures were measured, and the aortic stiffness index (β) determined by M‐mode analysis was calculated as a conventional parameter of arterial stiffness. The LS of the anterior and posterior ascending aortic wall (AW‐LS and PW‐LS) were determined. Results Compared to the control group (34.21 ± 5.25%), the mean LS of AA in HP patients (group A 28.6 ± 5.95%; group B 23.64 ± 4.98%; group C 17.93 ± 3.96%; P < .001) were significantly reduced. Multivariate logistic regression analysis showed that the mean LS (OR 0.719, 95% CI 0.615–0.839, P < .001) and pulse pressure (PP) (OR 1.055, 95% CI 1.006–1.106, P = .028) were identified as independent predictors of AAD in HP patients. The AUC of mean LS combined with PP reached 0.926 (sensitivity, 95.0%; specificity, 82.5%), which was higher than the mean LS, PP, stiffness index, and ascending aortic diameter (AAd) separately. Besides, the AW‐LS and PW‐LS were negatively correlated with the AAd, stiffness index, stroke volume, systolic blood pressure, and PP, respectively (P < .001). Conclusion The LS of AA evaluated by two‐dimensional speckle tracking echocardiography decreased significantly along with the expansion of aortic lumen and the occurrence of AAD in HP patients. It is also an independent predictor of AAD in HP patients.

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supporting

confidence: 58%

“…Our previous study has confirmed that the biomechanical parameters such as carotid arterial stiffness could be a supplemental indicator to predict AAD. 6 Hence, we deduced that the quantitative evaluation of ascending aortic mechanical behaviors might be another potentially personalized risk parameter in HP patients.…”

mentioning

confidence: 98%

Evaluation of Ascending Aortic Longitudinal Strain Via Two‐Dimensional Speckle Tracking Echocardiography in Hypertensive Patients Complicated by Type A Aortic Dissection

Pei

Wang

et al. 2021

J of Ultrasound Medicine

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“…Gu et al [14] evaluated the carotid stiffness of 150 researchers (including 50 hypertensive patients, 50 patients with acute aortic dissection and 50 healthy people) by ET. The results showed that the stiffness values (β and PWVβ) of the common carotid artery (CCA) in the acute aortic dissection group were significantly higher than those in the control group, and the compliance values (AC) were significantly lower than those in the control group, indicating that the CCA in acute aortic dissection patients was more rigid.…”

Section: Echo Tracking (Et) Techniquementioning

confidence: 99%

Application and Progress of Ultrasound Technology in Atherosclerosis

Gong¹,

Xue²

2023

Advanced Ultrasound in Diagnosis and Therapy

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Atherosclerosis (AS) is the main pathophysiological process behind CVD. Cardiovascular diseases caused by AS (such as stroke, coronary heart disease, etc.) are characterized by a high prevalence, high disability rate and high mortality, which greatly increase the burden on families and society. Thus, it is important to find AS as early as possible. When atherosclerosis occurs, the earliest sign of its structural and functional changes is arterial stiffness, and endothelial dysfunction is the key link.Arteriosclerosis is caused by the imbalance between collagen and elastin in the arteries. Elastin fibers gradually decrease, and stiffer collagen fibers increase, making the vessels less elastic. Endothelial dysfunction also affects the regulatory function of arterial vascular tension, and accelerates the remodeling of the vascular wall, to make blood vessels more rigid. Quantitative measurement of arterial stiffness and carotid intima-media thickness (CIMT) is an important tool for early detection of vascular lesions. At present, ultrasound technology including echo tracking (ET), wave intensity (WI), real-time shear wave elastography (SWE), ultrafast pulse wave velocity (ufPWV), shear wave dispersion (SWD), cardio-ankle vascular index (CAVI), arterial velocity pulse index and arterial pressure volume index (AVI and API) has the advantages of being noninvasive, realtime, economical and reproducible in the assessment of atherosclerosis, and is widely used in the early diagnosis of AS. Most importantly, the change in arterial hardness detected by traditional ultrasound technology precedes the change in intima-media thickness, suggesting that ultrasonic elasticity monitoring may be a more sensitive method of predicting AS and can find and prevent cardiovascular diseases earlier.

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Evaluation of early arterial wall lesions by elastography parameters in spontaneously hypertensive rats

Liu

Qiu

Yuan

et al. 2023

BMC Cardiovasc Disord

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Background Arterialsclerosis caused by hypertension can lead to many complications, such as heart attack, stroke and so on. Early diagnosis and treatment of arterialsclerosis can prevent cardiovascular and cerebrovascular diseases and improve the prognosis. The present study aimed to explore the value of ultrasonography in evaluating the early lesion of the local arterial wall in hypertensive rats and identify useful elastography parameters. Methods A total of 24 spontaneously hypertensive rats (SHR), 10-, 20-, 30-, and 40-weeks-old, were used in this study, with 6 rats in each group. Blood pressure was recorded using the Animal Noninvasive Blood Pressure Measurement System (Kent company, model CODA, USA), and the local elasticity of the abdominal aorta of rats was measured using a ultrasound diagnostic instrument (VINNO, Suzhou city, China). According to the histopathological results, SHR were divided into two groups: the normal arterial elasticity and the early arterial wall lesions. Mann–Whitney U test was used to compare the differences in elastic parameters and influencing factors between the above two groups, and receiver operating characteristic curve (ROC) was used to analyze and judge the value of each elastic parameter in evaluating early arterial lesions. Results A total of 22 cases were divided into two groups: 14 in the normal arterial elasticity and 8 in the early arterial wall lesions. The differences in age, blood pressure, pulse wave velocity (PWV), compliance coefficient (CC), distensibility coefficient (DC), and elasticity parameter (EP) between the two groups were compared. The differences in PWV, CC, DC and EP were statistically significant. Subsequently, the ROC curve analysis was performed for the above four evaluation indexes of arterial elasticity; the results were as follows: the area under the curve of PWV, CC, DC, and EP was 0.946, 0.781, 0.946, and 0.911, respectively. Conclusions Early arterial wall lesions can be evaluated by ultrasound measurement of local PWV. PWV and DC can accurately evaluate the early arterial wall lesions in SHR, and the combined application of the two can improve the sensitivity and specificity of the approach.

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Evaluation of Common Carotid Stiffness via Echo Tracking in Hypertensive Patients Complicated by Acute Aortic Dissection

Cited by 5 publications

References 25 publications

Evaluation of Ascending Aortic Longitudinal Strain Via Two‐Dimensional Speckle Tracking Echocardiography in Hypertensive Patients Complicated by Type A Aortic Dissection

Evaluation of Ascending Aortic Longitudinal Strain Via Two‐Dimensional Speckle Tracking Echocardiography in Hypertensive Patients Complicated by Type A Aortic Dissection

Application and Progress of Ultrasound Technology in Atherosclerosis

Evaluation of early arterial wall lesions by elastography parameters in spontaneously hypertensive rats

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