Evaluation of Computed Tomography Attenuation Value of Proximal Femoral Marrow to Diagnose and Differentiate Hematologic Malignancies, Myelofibrosis, and Aplastic Anemia

Ishii, Shiro; Ohkawara, Hiroshi; Endo, Yui; Hara, Junko; Hotsumi, Hirotoshi; Yamakuni, Ryo; Sugawara, Shigeyasu; Sekino, Hirofumi; Ito, Hiroshi

doi:10.1097/rct.0000000000001196

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“…In the clinical settings, increments in the CT attenuation of BM which may indicate hyperactivity of the red marrow, are occasionally observed in patients with an inflammatory response or after GCSF administration. Decreased CT attenuation of BM has also been reported in patients with diseases such as aplastic anemia [15]. Hematopoietic elements, being the most metabolically active and densely populated cells in the BM, are expected to contribute to higher values on both PET and CT scans.…”

Section: Introductionmentioning

confidence: 87%

“…Measurement of the CT number is useful for speculating on components such as fat, calcification, and hematoma. The CT attenuation of the femoral BM has been reported to be elevated in anemia and various hematological disorders [15,16]. In the clinical settings, increments in the CT attenuation of BM which may indicate hyperactivity of the red marrow, are occasionally observed in patients with an inflammatory response or after GCSF administration.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of factors affecting CT attenuation and glucose metabolism of bone marrow as seen on PET/CT scans

Ishii

2024

Am J Nucl Med Mol Imaging

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The aim of this study is to determine the factors affecting the CT attenuation of bone marrow, and its correlation with 18 F-FDG uptake. The mean standardized uptake value (SUV) of vertebral bone marrow (Vertebral-SUV) and femoral bone marrow (Femoral-SUV) as well as CT number of bone marrow (BM-CT number) were measured in 243 patients who had undergone 18 F-FDG PET/CT. The correlations among BM-CT number, Femoral-SUV, and Vertebral-SUV were investigated. The relationships of Femoral-SUV, Vertebral-SUV, and BM-CT number with blood parameters, age, blood sugar, and body weight were analyzed by correlation and multi-regression analyses. The Mann-Whitney U test and chi-square test and Binomial logistic analysis were used to examine the relationships between high BM-CT number (≥ 0 HU) and the above parameters. Significant correlations were observed between: BM-CT number and Femoral-SUV (r = 0.73, P < 0.01); Vertebral-SUV and Femoral-SUV (r = 0.78, P < 0.01); and BM-CT number and Vertebral-SUV (r = 0.52, P < 0.01). BM-CT number was correlated with patients' age in both univariable (r = -0.27) and multivariable analyses (β = -0.20). Positive BM-CT number correlated with WBC in both univariable (P = 0.04) and multivariable (P < 0.01) analyses. Bone marrow glucose metabolism had a tendency to decrease with age, was increased in patients with elevated CRP. In conclusion, CT attenuation of bone marrow correlated well with bone marrow metabolism and also tended to decrease with age. High bone marrow attenuation (≥ 0 HU) could predict elevated serum WBC.

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Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Investigation of factors affecting CT attenuation and glucose metabolism of bone marrow as seen on PET/CT scans

Ishii

2024

Am J Nucl Med Mol Imaging

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Evaluation of Computed Tomography Attenuation Value of Proximal Femoral Marrow to Diagnose and Differentiate Hematologic Malignancies, Myelofibrosis, and Aplastic Anemia

Abstract: The aim of this study was to diagnose hematologic diseases using computed tomography (CT) number of proximal femoral marrow. Methods:The average CT number of marrow in hematologic diseases was measured on the caudal side of the greater trochanter.

Cited by 1 publication

References 20 publications

Investigation of factors affecting CT attenuation and glucose metabolism of bone marrow as seen on PET/CT scans

Investigation of factors affecting CT attenuation and glucose metabolism of bone marrow as seen on PET/CT scans

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