Evaluation of Concordance Between Histopathological, Radiological and Biomolecular Variables in Breast Cancer Neoadjuvant Treatment

Buonomo, Oreste Claudio; Grasso, Andrea; Pistolese, Chiara Adriana; Anemona, Lucia; Portarena, Ilaria; Meucci, Rosaria; Morando, Ljuba; Deiana, Camilla; Materazzo, Marco; Vanni, Gianluca

doi:10.21873/anticanres.13950

Cited by 9 publications

(10 citation statements)

References 31 publications

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“…In order to provide the best clinical outcome, all surgeons and physicians involved in breast cancer care spent more than in vivo 34: 1685-1694 (2020) 50% of their working hours with minimum caseload (20,21). Breast Cancer treatment requires a profound knowledge of cancer behavior in order to reduce the risk of tumors progression (22)(23)(24). On the other hand, a surgical plan should be seen as an opportunity for breast remodeling that may enhance the woman's appearance (25)(26)(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

“…The total scores of these measurement tools were interpreted as follows: Depression, normal [0-9], mild [10][11][12][13], moderate [14][15][16][17][18][19][20], severe [21][22][23][24][25][26][27], extremely severe (28+); Anxiety, normal [0-7], mild [8][9], moderate [10][11][12][13][14], severe [15][16][17][18][19], extremely severe [20+]; Stress, normal [0-14], mild [15][16][17][18], moderate [19][20][21][22][23][24][25], severe [26][27][28][29][30][31][32][33], extremely severe [34+].…”

Section: Methodsmentioning

confidence: 99%

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The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey

Vanni

Materazzo

Santori

et al. 2020

In Vivo

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Background/Aim: Despite the large amount of clinical data available of Coronavirus-19 (COVID-19), not many studies have been conducted about the psychological toll on Health Care Workers (HCWs). Patients and Methods: In this multicentric descriptive study, surveys were distributed among 4 different Breast Cancer Centers (BCC). BCCs were distinguished according to COVID-19 tertiary care hospital (COVID/No-COVID) and district prevalence (DP) (High vs. Low). DASS-21 score, PSS score and demographic data (age, sex, work) were evaluated. Results: A total of 51 HCWs were analyzed in the study. Age, work and sex did not demonstrate statistically significant values. Statistically significant distribution was found between DASS-21-stress score and COVID/No-COVID (p=0.043). No difference was found in the remaining DASS-21 and PSS scores, dividing the HCWs according to COVID-19-hospital and DP. Conclusion: Working in a COVID-19-hospital represents a factor that negatively affects psychosocial wellbeing. However, DP seems not to affect the psychosocial well-being of BCC HCWs. During the outbreak, psychological support for low risk HCWs should be provided regardless DP. The first case of atypical pneumonia previously named as Severe Acute Respiratory Syndrome Corona Virus 2 (COVID-19) was recorded in December 2019 in China. Italy has been the first European country to be involved in this outbreak. The national health care system (NHS) is currently reallocating resources from elective and semi-elective patients toward severe COVID-19 patients (1, 2). Italy has exceeded the cases recorded in China and unfortunately, up to now (May, 17th), 225,435 cases and 31908 deaths have been registered with still over 700 admitted to intensive care units (3). The Italian outbreak is mainly located in clusters along the north of Italy (Lombardia, Veneto and Emilia Romagna) and a low incidence in central and southern regions (1, 3, 4). In order to control COVID-19, resource reallocation eventually led to the creation of hospitals partially or totally dedicated to COVID-19 patients (COVID-hospital), therefore 1685 This article is freely accessible online.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey

Vanni

Materazzo

Santori

et al. 2020

In Vivo

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“…In addition, during the outbreak, NAC should be strongly recommended to reduce the delay of treatment. Moreover, physicians could take advantage of these schedules as a temporary bridge treatment as well as a chance to treat patient with BC subset with low rate of pathological complete response, as LUM patients [ 15 , 16 ]. In this subset of patients, MDT could consider the partial response or the stable disease after neoadjuvant therapy as affordable goals during local outbreak peak to delay surgery and reduce risk of contamination.…”

Section: Discussionmentioning

confidence: 99%

Awake breast cancer surgery: strategy in the beginning of COVID-19 emergency

et al. 2020

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Introduction COVID-19 is a declared worldwide pandemic. In our country, due to shortage of hospitals and beds in intensive care unit, oncological and breast cancer (BC) resources are temporarily shifted to COVID-19 patients. In addition, risk of cross-infections should be considered in these frail patients. To accomplish more surgical procedures and to reduce the length of hospital stay (LOS), fast track awake BC surgery should be implemented. The aim of the study is to estimate the effects of surgical shift in our facility during the early COVID-19 outbreak. Materials and methods From 30th January 2020 to 30th of March 2020, 86 consecutive patients were retrospectively enrolled and divided into pre-COVID-19-BC and COVID-19-BC. Clinical parameters and anamnestic data were collected and analyzed. Surgical procedures, relative complications and type of anaesthesia were reported. The effect on surgical time (ST), operative room time (ORT) and length of stay (LOS) were described and examined. Results No statistical difference was found in complications rate, clinical data and surgical procedures ( p > 0.05). Awake breast conservative surgery (BCS) was the most frequent procedure in COVID-19-BC ( p = 0.006). A statistically significant decrease in ORT and LOS was reported in COVID-19-BC ( p = 0.040 and p = 0.0015 respectively), while comparable time resulted for ST ( p = 0.976). Mean ORT and LOS reduction were 20.79 min and 0.57 hospital bed days. Conclusion In the “COVID-19 era”, fast track awake breast surgery provides a reduction of ORT, LOS and potentially surgical treatment for a wider number of oncological patients.

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“…The modern era of BC treatment is headed by the knowledge of BC locoregional and metastatic behavior (50,51) and the subsequent development of systemic tailored strategy, i.e. neoadjuvant chemotherapy (52)(53)(54)(55). All these approaches together led to an increase in overall survival (OS) by 2.2% per year (56).…”

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confidence: 99%

Does Age Matter? Estimating Risks of Locoregional Recurrence After Breast-conservative Surgery

Vanni

Materazzo

Pellicciaro

et al. 2020

In Vivo

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Background/Aim: In 2016, in the United States, more than 50% of breast cancer (BC) cases were diagnosed in patients older than 60 years of age. Our study aimed to estimate the risk of locoregional recurrence (LR) in patients who underwent breast-conservative treatment (BCT), according to age. Patients and Methods: This retrospective monocentric study analyzed 613 cases of patients who underwent BCT between 2003 and 2014. Patients were divided into groups according to age: Under70 (under 70 years old) and Over70 (above 70 years old). Margins width, histology results, prognostic and predictive factors were compared. Subgroup analysis was performed for patients who experienced LR. Results: LR Incidence among Under70 and Over70 was 5.4% and 1.7%, respectively (p<0.01). Group Over70 is characterized by larger tumors and a lower Ki67 index (p<0.01). Conclusion: Operation time reduction, better aesthetic results and reduced LR risk support BCT. The Over70 group exhibited better outcomes in terms of LR despite larger tumor dimensions. Recent research of global cancer concludes that breast cancer (BC) represents the second most common cause of neoplasms with an overall number of more than 2 million cases worldwide (1). Demographic transition in developed countries predetermines increase in life expectancy and growth of the elderly population. Consequently, the growing numbers of BC diagnosis in aged patients point out the importance of a tailored approach even in this target population, avoiding undertreatment (2-4). Moreover, it is demonstrated that age is a strong factor influencing patient's choice of refusing surgery, with other demographic and disease-specific characteristics (5). In 2016, more than 50% of BCs were diagnosed in patients older than 60 years (6). Surgical management of BC is divided into two approaches: Mastectomy (Mx) and breastconservative treatment (BCT) (7, 8). Mx consists of breast gland complete removal with the possibility of sparing the Nipple Areola complex (9, 10). Breast reconstruction (BR) should be considered and offered to patients who undergo mastectomy, if not contraindicated by performance status or clinical stage of disease (11-13). Modern conception of breast surgery treatment shifts from preserving the breast appearance specifically to improvement of the general body image through an oncoplastic surgical technique (10, 14). BR can be performed through several techniques including lipofilling, myo-cutaneous autologous flaps and prosthetic implants (15, 16). Breast implants represent the first preference in 81.2% of cases (17). Between the years 2014 and 2018 the rate of Mx following immediate BR increased from 6.7% to 18.1% in women 65 years old or older (18). With that said, patients older than 65 1125 This article is freely accessible online.

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Evaluation of Concordance Between Histopathological, Radiological and Biomolecular Variables in Breast Cancer Neoadjuvant Treatment

Cited by 9 publications

References 31 publications

The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey

The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey

Awake breast cancer surgery: strategy in the beginning of COVID-19 emergency

Does Age Matter? Estimating Risks of Locoregional Recurrence After Breast-conservative Surgery

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