Evaluation of contact sensitivity to food additives in children with atopic dermatitis

Anıl, Hülya; Harmancı, Koray

doi:10.5114/ada.2020.96112

Cited by 9 publications

(12 citation statements)

References 23 publications

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“…The prevalence of AR ↓ Atopic dermatitis Processed foods and some food additives The occurrence and severity of AD ↑ [253,255] Breastfeeding for the first four months The risk of eczema in the first four years ↓ [257] Feeding infants with intensive eHF in the first 4-6 months, avoiding milk and dairy products Prevent the development of AD [257] Feeding eHF after the sixth month Not suppress the development of AD [258] Monounsaturated fatty acid Allergic sensitization in females, mostly no significant associations for males [258] High n−6/n−3 ratio Moderate to severe AD ↑ [260] The intake of n−6 fatty acids Lower in the severe AD group [261] n−3 PUFA docosahexaenoic acid Beneficial impact on AD [262] Supplementation with polyunsaturated fatty acids of the omega−3…”

Section: Environmental Subs Tan Ce S Affec Ting the Epithelial Barrier Smentioning

confidence: 99%

“… 253 Processed foods and some food additives such as monosodium glutamate (popular flavor enhancer) could act as pseudo‐allergens and increase the occurrence and severity of AD. 254 , 255 Maternal diet and antenatal nutrition could affect fetal development by altering fetal programming, which may in turn alter immune response and atopy. 256 Nutrition during infancy and childhood is very important for the development of AD, and breastfeeding for the first 6 months is thought to be effective in preventing the development of atopic diseases.…”

Section: Change In Dietary Habits and Allergic Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Sözener

Öztürk

Çerçi

et al. 2022

Allergy

221

166

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Environmental exposure plays a major role in the development of allergic diseases.The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external (e.g., chemical pollutants or lifestyle factors), and general external (e.g., broader socioeconomic and psychological contexts) domains, all of which are interrelated. All the factors we are exposed to, from the moment of conception to death, are part of the external exposome. Several hundreds of thousands of new chemicals have been introduced in modern life without our having a full understanding of their toxic health effects and ways to mitigate these effects.Climate change, air pollution, microplastics, tobacco smoke, changes and loss of biodiversity, alterations in dietary habits, and the microbiome due to modernization, urbanization, and globalization constitute our surrounding environment and external exposome. Some of these factors disrupt the epithelial barriers of the skin and mucosal surfaces, and these disruptions have been linked in the last few decades to the increasing prevalence and severity of allergic and inflammatory diseases such as atopic dermatitis, food allergy, allergic rhinitis, chronic rhinosinusitis, eosinophilic

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Section: Environmental Subs Tan Ce S Affec Ting the Epithelial Barrier Smentioning

confidence: 99%

Section: Change In Dietary Habits and Allergic Diseasesmentioning

confidence: 99%

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Sözener

Öztürk

Çerçi

et al. 2022

Allergy

221

166

View full text Add to dashboard Cite

show abstract

“…There has been recent controversy on the allergenicity of Genetically Modified (GM) products (127,128). Some studies have suggested that transgenic crops may have allergic effects, but some do not (129,130). Long-term studies are warranted to evaluate the risks of consumption of GM foods on the development of food allergies.…”

Section: Dietary Preferencesmentioning

confidence: 99%

“…In recent years, artificial sweeteners and food additives used to improve taste, color and stability of food products have been increasingly consumed and this may be associated with and increased risk of food allergy, AD, childhood asthma and AR (129)(130)(131)(132).…”

Section: Dietary Preferencesmentioning

confidence: 99%

The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis

et al. 2022

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IntroductionIn the last decades, we have seen a rapid increase in the prevalence of allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, and food allergies. The environmental changes caused by industrialization, urbanization and modernization, including dramatic increases in air pollutants such as particulate matter (PM), diesel exhaust, nitrogen dioxide (NO2), ozone (O3), alarming effects of global warming, change and loss of biodiversity, affect both human health and the entire ecosystem.ObjectiveIn this review, we aimed to discuss the effects of the external exposome on epithelial barriers and its relationship with the development of allergic diseases by considering the changes in all stakeholders of the outer exposome together, in the light of the recently proposed epithelial barrier hypothesis.MethodTo reach current, prominent, and comprehensive studies on the subject, PubMed databases were searched. We included the more resounding articles with reliable and strong results.ResultsExposure to altered environmental factors such as increased pollution, microplastics, nanoparticles, tobacco smoke, food emulsifiers, detergents, and household cleaners, and climate change, loss and change in microbial biodiversity, modifications in the consumption of dietary fatty acids, the use of emulsifiers, preservatives and the decrease in the antioxidant content of the widely consumed western diet may disrupt the epithelial barriers of the skin, respiratory and gastrointestinal tracts, making us more vulnerable to exogeneous allergens and microbes. Epithelial cell activation, microbial dysbiosis and bacterial translocation disrupt the immune balance and a chronic Th2 inflammation ensues.ConclusionDramatic increases in air pollution, worrisome effects of global warming, dysbiosis, changing dietary habits and the complex interactions of all these factors affect the epithelial barriers and local and systemic inflammation. We want to draw attention to the emerging health effects of environmental changes and to motivate the public to influence government policies for the well-being of humans and the nature of the earth and the well-being of future generations.

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“…Adverse reactions related to the consumption of artificial dyes are considered rare (Anil & Harmanci, 2020). There are significant individual variations and complex diagnoses, even in positive results (Turner & Kemp, 2012).…”

Section: Hazard Identification: Adverse Health Effectsmentioning

confidence: 99%

Risk assessment of azo dyes as food additives: Revision and discussion of data gaps toward their improvement

Ramos-Souza

Bandoni

Arisseto-Bragotto

et al. 2022

Comp Rev Food Sci Food Safe

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The food industry uses dyes mainly to overcome color loss during the processing and storage of products, with the azo dyes currently being the most employed. Studies on the safety of using these dyes in foods started in the 1950s and have indicated the potential for concern. This review discusses the risk assessment of food intake containing artificial azo dyes. There are case reports and, subsequently, double‐blind placebo‐controlled trials in some individuals who may experience adverse effects from the intake of azo dyes, but it is unclear whether these adverse effects are restricted to specific populations or more generalized. In view of this, different toxicological endpoints are evaluated to verify toxic effects in in vitro and in vivo models and to establish the no observed adverse effect level. Exposure estimation studies have shown that human exposure to azo dyes via oral intake is mainly below the acceptable daily intake established by advisory bodies. However, most countries do not have studies that estimate the oral intake of azo dyes. In this case, local food diversity and racial–ethnic specificities are not considered when stating the exposure estimate is below the acceptable daily intake for the human population and thus may not represent actual intake. Concerning the scenario established above, this review discusses the most critical gaps to be overcome to contribute to the direction of future studies and the development of more effective public policies concerning the safety of the intake of artificial azo dyes.

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Evaluation of contact sensitivity to food additives in children with atopic dermatitis

Cited by 9 publications

References 23 publications

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis

Risk assessment of azo dyes as food additives: Revision and discussion of data gaps toward their improvement

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