Evaluation of contrast media for bronchography

Thompson, I M; Whittlesey, Grant C.; Slovis, T. L.; Chang, Chung‐Ho; Cullen, Marc L.; Philippart, Arvin I.; Stockmann, P S; Adkins, E S; Klein, Michael D.

doi:10.1007/s002470050194

Cited by 10 publications

(8 citation statements)

References 14 publications

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“…Beginning with the historic use of Barium for bronchography in 1967, which was later described as a "deadly examination," safety of contrast agents has remarkably improved. [14][15][16] Although aspiration of barium sulfate into the bronchial tree was once thought to be harmless, serious complications and several deaths have been reported due to barium aspiration in both children and adults. 8,10,11,17,18 Barium has been shown to persist in distal airspaces and has long been thought to collect in the mediastinum and cause granuloma and chronic infection.…”

Section: Discussionmentioning

confidence: 99%

The effect of aspirated barium sulfate, iodixanol, and diatrizoic acid on survival and lung injury in a lagomorph model

et al. 2017

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Section: Discussionmentioning

confidence: 99%

The effect of aspirated barium sulfate, iodixanol, and diatrizoic acid on survival and lung injury in a lagomorph model

et al. 2017

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“…After iopamidol administration, the regeneration was not completed in the course of two days (Konnldova et al 1996). Recently, the light microscopic study of the rabbits' airways after iohexol tracheobronchography showed relatively severe inflammatory and even necrotic changes in the area of the mucous membrane (Thompson et al 1997). Therefore, we decided to extend our studies and to investigate also the reaction of the epithelium in terminal bronchioles to this diagnostic procedure.…”

mentioning

confidence: 99%

Effect of Intratracheal Administration of Iopamidol on the Ultrastructure of the Epithelium of Terminal Bronchioles in Rabbits (Oryctolagus cuniculus var. edulis)

Uhlı́k¹,

Tůma²

1998

Acta Vet. Brno

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The ultrastructure of the epithelium of terminal bronchioles in rabbits was studied 40 minutes after intratracheal administration of iodinated water-soluble non-ionic contrast agent iopamidol. The signs of pathological alteration of the epithelial cells may be a result of the transitional hypoxia during administration. The secretory Clara cells were not stimulated to release their secretion, nor the signs of epithelial cells' proliferation were noticed. Terminal bronchioles, rabbit, ultrastructure, colltrast agents, tracheobronchographyIn spite of an extensive development of non-invasive radiological techniques, the tracheobronchography remains irreplaceable diagnostic method visualising the airways. In our previous study, we aimed at finding the most suitable contrast agent from the morphological point of view evaluating the degree of damage to the airway epithelium. In experiment, the ultrastructure of the epithelium of large extrapulmonary airways was thoroughly studied shortly after intratracheal administration of three iodinated water-soluble contrast agents (iopamidol, iohexol and Na-meglumine ioxaglate) (Konnidova et al. 1990(Konnidova et al. , 1995. The administration of iopamidol caused only mild damage to the tracheal epithelium, while the degree of injury of this epithelium due to administration of other two agents was classified as moderate to severe. After iopamidol administration, the regeneration was not completed in the course of two days (Konnldova et al. 1996). Recently, the light microscopic study of the rabbits' airways after iohexol tracheobronchography showed relatively severe inflammatory and even necrotic changes in the area of the mucous membrane (Thompson et al. 1997). Therefore, we decided to extend our studies and to investigate also the reaction of the epithelium in terminal bronchioles to this diagnostic procedure. Materials and MethodsSix clinically healthy rabbits (males, body weight 1,740 g -3,800 g) were used. Under general anaesthesia (ketamine 35 mg/kg and xylazine 5 mg/kg intramuscularly), we cannulated the tracheae of three of them and injected 0.5 ml of iopamidol (N,N' -bis(2-hydroxy-l-hydroxy-methyl-ethyl)-2.4,6-triiodo-5-lactamidoisophthalamide) (IOPAMIRO 300, Bracco, Milan, Italy) into their airways under the X-ray control (Plate III., Fig. I). The animals breathed regularly and did not show any signs of breathlessness. Forty minutes post exposure, the thorax was opened and lungs were removed. The lung better filled with the contrast agent was immediately perfused by 5% glutaraldehyde in O.IM cacodylate buffer (pH 7.2) and one of the lobes was transversely sectioned. Tiny pieces of the tissue were collected, fixed for 90 minutes with the same fixative and then for 60 minutes with 2% OS04 in the same buffer (pH 7.4). The material was dehydrated in graded series of alcohol and embedded in a Durcupan-Epon mixture. Terminal bronchioles were localised in semithin sections stained with toluidine blue.

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“…Yet according to an animal experiment (28) and previous clinical studies (10-13), a small volume of barium instillation did not show significant pulmonary parenchymal damage and is considered to be safe (10-13, 28). We believe that the very small amount of barium sulfate used in our study is does not pose that risk.…”

Section: Discussionmentioning

confidence: 99%

CT-Guided Percutaneous Transthoracic Localization of Pulmonary Nodules Prior to Video-Assisted Thoracoscopic Surgery Using Barium Suspension

et al. 2012

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ObjectiveTo describe our initial experience with CT-guided percutaneous barium marking for the localization of small pulmonary nodules prior to video-assisted thoracoscopic surgery (VATS).Materials and MethodsFrom October 2010 to April 2011, 10 consecutive patients (4 men and 6 women; mean age, 60 years) underwent CT-guided percutaneous barium marking for the localization of 10 small pulmonary nodules (mean size, 7.6 mm; range, 3-14 mm): 6 pure ground-glass nodules, 3 part-solid nodules, and 1 solid nodule. A 140% barium sulfate suspension (mean amount, 0.2 mL; range, 0.15-0.25 mL) was injected around the nodules with a 21-gauge needle. The technical details, surgical findings and pathologic features associated with barium localizations were evaluated.ResultsAll nodules were marked within 3 mm (mean distance, 1.1 mm; range, 0-3 mm) from the barium ball (mean diameter, 9.6 mm; range, 8-16 mm) formed by the injected barium suspension. Pneumothorax occurred in two cases, for which one needed aspiration. However, there were no other complications. All barium balls were palpable during VATS and visible on intraoperative fluoroscopy, and were completely resected. Both the whitish barium balls and target nodules were identifiable in the frozen specimens. Pathology revealed one invasive adenocarcinoma, five adenocarcinoma-in-situ, two atypical adenomatous hyperplasias, and two benign lesions. In all cases, there were acute inflammations around the barium balls which did not hamper the histological diagnosis of the nodules.ConclusionCT-guided percutaneous barium marking can be an effective, convenient and safe pre-operative localization procedure prior to VATS, enabling accurate resection and diagnosis of small or faint pulmonary nodules.

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Evaluation of contrast media for bronchography

Abstract: From the histologic and imaging results, barium is the best available contrast material for bronchography.

Cited by 10 publications

References 14 publications

The effect of aspirated barium sulfate, iodixanol, and diatrizoic acid on survival and lung injury in a lagomorph model

The effect of aspirated barium sulfate, iodixanol, and diatrizoic acid on survival and lung injury in a lagomorph model

Effect of Intratracheal Administration of Iopamidol on the Ultrastructure of the Epithelium of Terminal Bronchioles in Rabbits (Oryctolagus cuniculus var. edulis)

CT-Guided Percutaneous Transthoracic Localization of Pulmonary Nodules Prior to Video-Assisted Thoracoscopic Surgery Using Barium Suspension

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