Evaluation of copper nanoparticles and copper sulfate effect on immune status, behavior, and productive performance of broilers

El-kazaz, Sara E.; Hafez, Mona H.

doi:10.5455/javar.2020.g388

Cited by 27 publications

(7 citation statements)

References 17 publications

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“…Another study informed that leukopenia might be due to the fact of increased leukocyte mobilization to protect the body in copper-damaged tissue [58]. Moreover, lymphocytopenia could be attributed to the weakening of the immune system caused by Cu or by oxidative stress release due to the fact of Cu poisoning [59,60]. Another experiment stated that excess dietary supplementation levels with nano-Cu led to the reduction of WBCs, Hb, hematocrit, and RBCs in chickens [61].…”

Section: Discussionmentioning

confidence: 99%

Alleviating Effects of Vitamins C and E Supplementation on Oxidative Stress, Hematobiochemical, and Histopathological Alterations Caused by Copper Toxicity in Broiler Chickens

Hashem

Hamied

Ahmed

et al. 2021

Animals

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The current investigation evaluated the alleviating effects of vitamin C and vitamin E on oxidative stress, hematobiochemical, and histopathological changes in the kidney induced by copper sulfate (CuSO4) toxicity in chickens. Two hundred and fifty-one-day-old male broiler chicks were randomly allotted into five experimental groups (five replicates/group, ten chicks/replicate): 1st group—basal diet with no additives (control group), 2nd group—basal diet complemented with CuSO4 (300 mg/kg diet), 3rd group—basal diet with CuSO4 (300 mg/kg diet) + vitamin C (250 mg/kg diet), 4th group—basal diet with CuSO4 (300 mg/kg diet) + vitamin E (250 mg/kg diet), and 5th group—basal diet with CuSO4 (300 mg/kg diet) + vitamin C (250 mg/kg diet) + vitamin E (250 mg/kg diet) for a 42 day feeding period. The results showed a significant reduction in red blood cells (RBCs), hemoglobin (Hb) concentration, and hematocrit values as well as total leukocyte counts (WBCs), lymphocyte, heterophil, and monocyte counts in the CuSO4-intoxicated birds (2.42 × 106/µL, 9.54 g/dL, 26.02%, 15.80 × 103/µL, 7.86 × 103/µL, 5.26 × 103/µL, and 1.18 × 103/µL, respectively, at the 6th week) compared to (2.79 × 106/µL, 10.98 g/dL, 28.46%, 21.07 × 103/µL, 10.84 × 103/µL, 7.12 × 103/µL, and 1.60 × 103/µL, respectively) in the control group. Moreover, CuSO4-intoxicated birds showed hypoglycemia with a rise in serum uric acid and creatinine levels (122.68, 5.18, and 0.78 mg/dL at the 6th week) compared to (159.46, 4.41, and 0.61 mg/dL) in the control group. The CuSO4 toxicity in birds induced oxidative stress, indicated by a high serum malondialdehyde level (MDA) and diminished activity of the antioxidant enzymes (glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD)) (2.01 nmol/mL, 37.66 U/mL, and 2.91 U/mL, respectively, at the 6th week) compared to (1.34 nmol/mL, 57.00 U/mL, 4.99 U/mL, respectively) in the control group. High doses of Cu exposure caused severe microscopic alterations in kidney architecture. The addition of vitamins C and E, singularly or in combination, displayed a beneficial effect in alleviating these harmful effects of Cu toxicity. These findings showed the possible mitigating impacts of dietary antioxidants on the hematobiochemical alterations, oxidative stress, and kidney damage induced by CuSO4 toxicity.

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Section: Discussionmentioning

confidence: 99%

Alleviating Effects of Vitamins C and E Supplementation on Oxidative Stress, Hematobiochemical, and Histopathological Alterations Caused by Copper Toxicity in Broiler Chickens

Hashem

Hamied

Ahmed

et al. 2021

Animals

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“…The deposition of Se in the testicular and ovarian tissues is increased in a concentration-dependent manner. This might be due to the improved uptake of the nanoparticles by the tissues and their diffusion across the cell membrane [ 4 , 33 , 57 ]. It has been shown that nano-Se absorption from the intestinal lumen is more heightened than sodium selenite.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of nano-selenium improves reproductive performance, sexual behavior and deposition of selenium in the testis and ovary of Japanese quail

El-kazaz¹,

Abo-Samaha²,

Hafez³

et al. 2020

J Adv Vet Anim Res

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“…The Nano-Cu supplementation in rabbit signi cantly increased activity of superoxide dismutase enzyme compared with the control group, however catalase was uneffected [36]. Cu-NP treatment signi cantly enhanced SOD and reduced MDA levels in broilers when compared to the control and CuSO 4 treated birds [47]. Likewise, Vaswani et al [29] found that TAS as antioxidant activity (FRAP value) was higher (P<0.05) in heifers receiving Cu supplemented diets in growing heifers.…”

Section: Biomarkers Of Antioxidant Statusmentioning

confidence: 99%

Nano Copper Supplementation Increases Superoxide Dismutase and Catalase Gene Expression Profiles and Concentration of Antioxidants and Immune Variables in Sahiwal Heifers

Kushwaha

Kumar

et al. 2022

Biol Trace Elem Res

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This study was conducted to evaluate the effect of inorganic and nano copper (Cu) supplementation on superoxide dismutase (SOD) and catalase (CAT) gene expression, antioxidant status and immune response in growing Sahiwal heifers. Twenty four Sahiwal heifers were allocated at random into four groups of six heifers in each groups and fed for 120 days. Feeding regimen was similar in all the groups except that treatment groups were supplemented with 0.0 mg Cu, 10.0 mg inorganic Cu, 5.0 and 10.0 mg of nano Cu per kg dry matter (DM) in four respective groups. Feed intake and growth performance were similar in growing Sahiwal heifers fed on basal diet with or without supplemental Cu. Antioxidative variables like SOD, CAT, ceruloplasmin (Cp), total antioxidant status (TAS) and glutathione peroxidase (GSH-Px) were found higher in Cu supplemented groups than control. Variables like malondialdehyde (MDA) and lipid peroxidation (LPO) were found lower in treatment groups than control. Total immunoglobulins (total Ig) and immunoglobulin G (IgG) were higher in treatment groups than control. Although, interleukin-6 (IL-6) was similar in all groups. There were upregulation of mRNA expression of SOD and CAT genes in experimental animals fed on Cu supplemented diet while mRNA expression of interleukin-6 (IL-6) and interleukin-10 (IL-10) genes were not altered by dietary treatment. The results suggest that level of 5 ppm nano Cu can be selected for feeding in growing cattle as it exerts similar effects as showed by 10 ppm inorganic Cu.

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Evaluation of copper nanoparticles and copper sulfate effect on immune status, behavior, and productive performance of broilers

Cited by 27 publications

References 17 publications

Alleviating Effects of Vitamins C and E Supplementation on Oxidative Stress, Hematobiochemical, and Histopathological Alterations Caused by Copper Toxicity in Broiler Chickens

Alleviating Effects of Vitamins C and E Supplementation on Oxidative Stress, Hematobiochemical, and Histopathological Alterations Caused by Copper Toxicity in Broiler Chickens

Dietary supplementation of nano-selenium improves reproductive performance, sexual behavior and deposition of selenium in the testis and ovary of Japanese quail

Nano Copper Supplementation Increases Superoxide Dismutase and Catalase Gene Expression Profiles and Concentration of Antioxidants and Immune Variables in Sahiwal Heifers

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