Evaluation of core-needle biopsy in indeterminate breast masses with no significant imaging finding

Abstract

Introduction: Breast cancer is the most common cause of death due to malignancy among females. Breast ultrasonography plus mammography could enhance the breast cancer detection.Aim of the study: to assess the value of core biopsy in the early diagnosis of atypia and malignancy in ambiguous breast lesions corresponding to the Breast Imaging Reporting and Data system (BI-RADS) in mammographic findings and complementary breast ultrasonography.Subjects and Methods: 50 female patients with indeterminate breast lump were recruited. From all patients, an ultrasound-guided core-needle biopsy was taken from breast lesions. The BI-RADS scores in mammography were detected.Results: All patients had BI-RADS 3 with breast lesions sizes ranged from 14-90 mm in 64% and 14-68 mm in 36% of them. 94% of lesions were benign, 68% were Fibroadenomas, 2% was a fibrocystic disease with ductal hyperplasia with no atypia, 12% were Fibrocystic disease without ductal hyperplasia, and 12% showed periductal mastitis. No upgrades were detected in lumpectomy histopathological analyses for both patients. Conclusion:Ultrasound-guided core biopsy is necessary for investigating clinically indeterminate breast masses in symptomatizing patients with irrelevant changes in imaging for early detection of malignancy and atypical hyperplastic changes.