Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: A pilot study

Shamsa, Ali; Hosseinzadeh, Hossein; Molaei, Mahmood; Shakeri, Mohammad Taghi; Rajabi, Omid

doi:10.1016/j.phymed.2009.03.008

Cited by 90 publications

(59 citation statements)

References 18 publications

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“…2017; 19(9):e13676. study was conducted on male erectile dysfunction, reporting the beneficial effects of saffron on male sexual function (39). These studies measured the effects of saffron and its components on sexual dysfunction (erection problems) (14,39).…”

Section: Discussionmentioning

confidence: 99%

Effects of Saffron Aqueous Extract and Its Main Constituent, Crocin, on Health-Related Quality of Life, Depression, and Sexual Desire in Coronary Artery Disease Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Abedimanesh

Ostadrahimi

Bathaie

et al. 2017

Iran Red Crescent Med J

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Background: Depression and sexual problems are common in patients with coronary artery disease (CAD) and can influence their quality of life. Objectives: The aim of this study was to compare the efficacy of saffron and its main constituent, crocin, in improving mental and sexual health and ultimately quality of life in CAD patients. Methods: This double-blind, placebo-controlled, randomized clinical trial was carried out during 8 weeks in 3 groups, including 1 placebo and 2 intervention groups. The study sample included 58 CAD patients within the age range of 40 -65 years, referred to Shahid Madani cardiovascular hospital, Tabriz, Iran, from April 2015 to November 2016. The intervention groups received saffron aqueous extract (SAE; 30 mg; n, 20) or crocin (30 mg; n,19). All the groups completed the demographic questionnaire, Beck depression inventory-II (BDI-II), Hulbert index of sexual desire (HISD), and MacNew health-related quality of life questionnaire.

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Section: Discussionmentioning

confidence: 99%

Effects of Saffron Aqueous Extract and Its Main Constituent, Crocin, on Health-Related Quality of Life, Depression, and Sexual Desire in Coronary Artery Disease Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Abedimanesh

Ostadrahimi

Bathaie

et al. 2017

Iran Red Crescent Med J

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“…12 The aphrodisiac properties of C. sativus stigma aqueous extract and its constituent crocin have been shown in previous studies. 13,14 In a pilot study by Shamsa et al, 14 20 men with ED have been treated with 200 mg saffron daily. After 10 days, saffron exerted positive effect on EF.…”

Section: Introductionmentioning

confidence: 99%

An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment

2010

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An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment MR Safarinejad, N Shafiei and S Safarinejad Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran Saffron (Crocus sativus Linn.) have been perceived by the public as a strong aphrodisiac herbal product. However, studies addressing the potential beneficial effects of saffron on erectile function (EF) in men with ED are lacking. Our aim was to evaluate the efficacy and safety of saffron administration on EF in men with ED. After a 4-week baseline assessment, 346 men with ED (mean age 46.6 ± 8.4 years) were randomized to receive on-demand sildenafil for 12 weeks followed by 30 mg saffron twice daily for another 12 weeks or vice versa, separated by a 2-week washout period. To determine the type of ED, penile color duplex Doppler ultrasonography before and after intracavernosal injection with 20 lg prostaglandin E 1 , pudendal nerve conduction tests and impaired sensory-evoked potential studies were performed. Subjects were assessed with an International Index of Erectile Function (IIEF) questionnaire, Sexual Encounter Profile (SEP) diary questions, patient and partner versions of the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire and the Global Efficacy Question (GEQ) 'Has the medication you have been taking improved your erections?' No significant improvements were observed with regard to the IIEF sexual function domains, SEP questions and EDITS scores with saffron administration. The mean changes from baseline values in IIEF-EF domain were þ 87.6% and þ 9.8% in sildenafil and placebo groups, respectively (P ¼ 0.08). We did not observe any improvement in 15 individual IIEF questions in patients while taking saffron. Treatment satisfaction as assessed by partner versions of EDITS was found to be very low in saffron patients (72.4 vs 25.4, P ¼ 0.001). Mean per patient 'yes' responses to GEQ was 91.2 and 4.2% for sildenafil and saffron, respectively (P ¼ 0.0001). These findings do not support a beneficial effect of saffron administration in men with ED.

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“…However, the regulatory mechanism of Cd tolerance in saffron is still unknown. Saffron (Crocus sativus), a perennial herb belonging to the Iridaceae, is heavily used in traditional medicine because of its anticancer, antioxidative, antidepressant, anticonvulsant and learning-and memory-enhancing properties (MACCARONE et al, 2008;SHAMSA et al, 2009;ASADI et al, 2014). There is only one study which reports the effect of Cd on saffron and they only investigated the heavy metal concentration in saffron (ABOU-ARAB; ABOU DONIA 2000).…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of saffron (Crocus sativus L.) grown under conditions of cadmium toxicity

Rao¹,

Lv²,

Yang³

2017

Biosci. J.

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Cd is a highly detrimental global environmental pollutant. Plants have evolved complex defense mechanisms as an adaptation to against Cd toxicity. In this study, a pot experiment was performed to evaluate the protein profile of saffron in response to Cd stress. Fifteen proteins were found to be up-regulated in the leaves of plants under Cd stress and were primarily related to metabolism, signal transduction, stress and defense response and energy. Eleven proteins were found to be down-regulated following Cd treatment, including ribulose bisphosphate carboxylase/oxygenase (Rubisco), ferredoxin-NADP reductase, a 70 kDa heat shock-related protein and three protein synthesis-associated proteins. The results provide valuable insights regarding the molecular mechanism of saffron in response to Cd toxicity and the possible utilization of genetic resources in developing Cd tolerant/low-accumulation saffron.

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Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: A pilot study

Cited by 90 publications

References 18 publications

Effects of Saffron Aqueous Extract and Its Main Constituent, Crocin, on Health-Related Quality of Life, Depression, and Sexual Desire in Coronary Artery Disease Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Effects of Saffron Aqueous Extract and Its Main Constituent, Crocin, on Health-Related Quality of Life, Depression, and Sexual Desire in Coronary Artery Disease Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment

Proteomic analysis of saffron (Crocus sativus L.) grown under conditions of cadmium toxicity

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