Evaluation of Crohn Disease Activity Using a Potential Abbreviated MRE Protocol Consisting of Balanced Steady-State Free Precession MRI Only Versus Full-Protocol MRE

Role of abbreviated non-contrast-enhanced MR-enterography in the evaluation of Crohn's disease activity and complications as an alternative for full protocol contrast-enhanced study: A systematic review and meta-analysis

“…All similar to CE-MRE ( p >0.05) DW-MRE consisting of T2 and DWI can be a reliable alternative for monitoring postoperative recurrence. Jhaveri, 2021 [51] T2w sequences (trueFISP) CE-MRE - clinical score (HBI) small bowel and colon active inflammation, penetrating disease, fibrostenotic disease adults T2w bSSFP showed 97% Sens and 100% Spec for reader A and 98% Sens and 86% Spec and a perfect concordance with full protocol MRE (κ = 0.91 and κ = 0.98 for reader A and B) bSSFP showed high diagnostic accuracy and robust concordance with MRE in assessing CD activity. Strakšyte, 2020 [60] DWI and ADC ileocolonoscopy ileum and colon active inflammation mixed DWI score showed 96.9% Sens and 82.3% Spec.…”

“…trueFISP: true fast imaging with steady-state precession. Study Alternative sequence Reference test Bowel sites that were examined Assessed condition Age group Main results for active complications Conclusion/interpretation Jhaveri, 2021 [51] T2w sequences (trueFISP) CE-MRE - clinical score (HBI) small bowel and colon active inflammation, penetrating disease, fibrostenotic disease adults TrueFISP and CE-MRE concordance for penetrating disease: Kappa=0.43–49 For stenotic disease: Kappa=0.38–0.31 There was a weak agreement between TrueFISP and full protocol MRE for diagnosing penetrating or stenotic complications. Meng, 2020 [91] MTI histopathology small bowel and colon Fibrosis adult Standardized MTR: 89.5% AUC Normalized MTR: 88.5% AUC MTR: 79.8% AUC MTR has a good correlation with fibrosis scores.…”

“…CE-MRE has been shown to have good accuracy in identifying such lesions [50] , and recent studies have analyzed the diagnostic capabilities of abbreviated protocols in this regard. While some studies show the strong consensus of T2w-based bSSFP/true FISP with CE-MRE in identifying all three main complications [51] , others demonstrate the lower ability of abbreviated protocols in identifying penetrating disease, indicating the need for CE-MRE [52] . Fibrostenotic lesions are the most common complication of CD and can be challenging to diagnose accurately.…”

Isotropic dynamic contrast-enhanced magnetic resonance imaging using differential subsampling with cartesian ordering and adaptive imaging receive coil for the diagnosis of Crohn disease: a case description

“…MR-fluoroscopic sequences have also been used to assess bowel distension or stricture ( 11 ). b-SSFP was also recently proposed as an MRE protocol for CD activity and complication assessment and has shown robust agreement with the full MRE protocol ( 12 ).…”