This study was conducted in pots under a polycarbonate greenhouse to determine the effects of different irrigation levels and vermicompost doses on the morphological and phenological characteristics, water consumption, water use efficiency, and yield parameters of tomato plants. For this purpose, different irrigation levels of 100%, 75%, 50% (I100: full irrigation, I75, I50) and vermicompost (VC) doses of 0, 10% and 20% (VC0, VC10 and VC20, w/w) were applied as the treatments. The study’s results determined the irrigation levels and vermicompost doses affected the tomato plants’ morphological and fruit quality parameters. The highest and lowest plant water consumption (ET) values for the treatments were determined as 47.8 L (I100VC10) and 21.2 L (I50VC0), respectively. Moreover, irrigation water levels and vermicompost doses significantly influenced the total yield of tomatoes. The highest and lowest total and marketable yields were obtained from the I100VC20 and I50VC0 irrigation levels and vermicompost doses. Similarly, the highest and lowest total water use efficiencies were achieved from the I100VC20 (21.9 g L−1) and I50VC0 (11.0 g L−1) treatments. Furthermore, the highest and lowest marketable water use efficiencies were obtained from the I100VC20 (21.9 g L−1) and I50VC0 (7.8 g L−1) treatments. The yield response factor (ky) was found to be 1.42. Although the highest efficiency was achieved from 100% full irrigation and a 20% vermicompost dose in the study, it is suggested that 75% irrigation level and 10% fertilizer doses can also be applied in places where water is limited and fertilizer is expensive. The results revealed that the appropriate irrigation level and vermicompost doses could reliably be used to enhance tomato yield.