The objective of this study is to assess the suitability of the AquaCrop model for growing maize using brackish water irrigation in Northwest China. Additionally, this study aims to examine how maize utilizes water in various soil layers when irrigated with varying water qualities. The AquaCrop model was calibrated and verified using experimental data from the years 2022 and 2023 in this research. (1) The findings indicated that the AquaCrop model effectively simulated the canopy cover, biomass, and yield of maize when irrigated with brackish water. The validation year’s R2, MAPE, and RMSE values for canopy cover, biomass, and yield of maize were 0.95, 5.36%, and 4.77%, respectively. For biomass, the R2, MAPE, and RMSE values were 0.91, 16.61%, and 2.12 t·hm−2, respectively. For yield, the R2, MAPE, and RMSE values were 0.84, 3.62%, and 0.42 t·hm−2, respectively. (2) Irrigation with water of high mineral content, measured at 1.6 ds/m, as well as with fresh water over the whole reproductive period, resulted in an increased reliance on groundwater for maize cultivation. There was no notable disparity in the usage of various soil layers between the irrigation with alternating freshwater and brackish water. (3) The AquaCrop model simulated the effects of seven different irrigation water quality treatments. It was shown that using water with mineralization levels of 0.5 and 0.8 ds/m resulted in decreased freshwater use without causing a substantial decrease in maize yield and biomass.