Evaluation of cross-linked chitosan microparticles containing acyclovir obtained by spray-drying

Stulzer, Hellen Karine; Tagliari, Monika Piazzon; Parize, Alexandre Luís; Silva, Marcos Antônio Segatto; Laranjeira, Mauro C. M.

doi:10.1016/j.msec.2008.07.030

Cited by 85 publications

(36 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar profiles have been reported by Laus et al 29 and Stulzer et al. 32 A high TPP concentration in the microparticles promotes interaction between (PO 4 )…”

supporting

confidence: 86%

See 1 more Smart Citation

Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying

Parize¹,

Stulzer²,

Laranjeira³

et al. 2012

Quím. Nova

Self Cite

View full text Add to dashboard Cite

Recebido em 21/8/11; aceito em 11/1/12; publicado na web em 15/5/12The aim of this study was to encapsulate curcumin into chitosan, using sodium tripolyphosphate (TPP) as an ionic crosslinker by the spray drying method. The influence of TPP on the properties of the final product, such as solubility, morphology, loading efficiency, thermal behavior, swelling degree and release profiles, was evaluated. The microparticles had a spherical morphology (0.5-20 µm) with no apparent porosity or cracks. Results indicated the formation of a polymeric network, which ensures effective protection for curcumin. Controlled-release studies were carried out at pH 1.2 and 6.8, to observe the influence of pH on curcumin release while the mechanism was analyzed using the Korsmeyer-Peppas equation.

show abstract

“…Similar profiles have been reported by Laus et al 29 and Stulzer et al. 32 A high TPP concentration in the microparticles promotes interaction between (PO 4 )…”

supporting

confidence: 86%

“…Curcumin binds to the new polymeric network via hydrogen bonds, promoting greater pigment dispersion and stability. Stulzer et al 32 observed similar profiles in a study on chitosan/TPP used for acyclovir microencapsulation.…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 70%

Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying

Parize¹,

Stulzer²,

Laranjeira³

et al. 2012

Quím. Nova

Self Cite

View full text Add to dashboard Cite

show abstract

“…Stulzer et al 37 fabricated hydrogel microparticles and inclusion complexes for insulin delivery through an oral route. They copolymerized methacrylic acid (monomer; MAA), chitosan, and polyethylene glycol (PEG) in the presence of an ethylene dimethacrylate cross-linker and potassium persulfate (KPS) as an initiator on a magnetic stirrer.…”

Section: Ionic Gelation Methodsmentioning

confidence: 99%

“…Stulzer et al 37 prepared chitosan microparticles by spray drying. In a typical experiment, antiviral drug was made soluble in 0.1 mol/L HCl solution.…”

Section: Spray Dryingmentioning

confidence: 99%

“…57 Hydrogel microparticles are employed in enhancement of hydrophobic and poorly watersoluble drugs like acyclovir whose solubility has been enhanced by the formation of chitosan hydrogel microparticles. 37 These exhibit controlled and prolonged release of drug by modifying swelling properties of microparticles. Polyvinyl alcohol (PVA) and PEG are most commonly used polymers for controlled delivery of drugs.…”

Section: Applications Of Hydrogel Microparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogel Microparticles as an Emerging Tool in Pharmaceutical Field: A Review

2015

View full text Add to dashboard Cite

From past few decades, emphasis of scientists is on the development of micro-and nanosized dosage forms to achieve the targeted and desired response from drugs. In this manner, they have developed microspheres, nanoparticles, niosomes, liposomes, etc. Now in recent past, work is going on the development of novel hydrogel microparticles that have more desirable response than conventional hydrogels. These newly developed hydrogel microparticles have a number of advantages over the conventional hydrogels as well as over other micro-or nanotechnologies. These are used to achieve either sustained or prolonged action as well as rapid release of drugs by complexation with hydrophilic polymers to enhance their solubility and ultimately bioavailability of poorly water-soluble drugs. Various techniques are used to prepare hydrogel microparticles such as the ionic gelation method, spray drying, dispersion, photopolymerization ionotropic gelation method, free radical precipitation polymerization, inverse emulsion polymerization, free radical polymerization, etc. Certain polymers along with various types of initiators, cross-linkers, and monomers are used in different concentrations depending upon the purpose of hydrogel microparticles. In recent review, we have focused upon the loading and drug release patterns from hydrogel microparticles, various technologies, and components applied in their preparations and applications in the pharmaceutical field. Hydrogel microparticles can be aimed for various purposes such as solubility enhancement of hydrophobic drugs, and targeted drug delivery, magnetic carriers; therefore, these are useful assets of pharmaceutical market. C 2015 Wiley Periodicals, Inc. Adv Polym Technol 2016, , 21535; View this article online at wileyonlinelibrary.com.

show abstract

Quality Assessment of API in Semisolid Topical Drug Products

Yeoh

Hsieh

et al. 2019

The Role of Microstructure in Topical Drug Product Development

View full text Add to dashboard Cite

Evaluation of cross-linked chitosan microparticles containing acyclovir obtained by spray-drying

Cited by 85 publications

References 16 publications

Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying

Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying

Hydrogel Microparticles as an Emerging Tool in Pharmaceutical Field: A Review

Quality Assessment of API in Semisolid Topical Drug Products

Contact Info

Product

Resources

About