Evaluation of Current Evidence on the Use of Oral Antiseptics Against SARS-CoV-2

Chumpitaz-Cerrate, Víctor; Chávez-Rimache, Lesly; Ruiz-Ramírez, Eliberto; Franco-Quino, César; Paredes, Carlos Erazo

doi:10.4103/jispcd.jispcd_65_22

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Treatment with oral antiseptics has been shown to contribute to eliminating SARS-CoV-2 from the O.C. by some preliminary clinical evidence [172,173]. The most effective oral antiseptics against SARS-CoV-2 are, in fact, povidone-iodine, hydrogen peroxide, and cetylpyridinium chloride, which were shown to reduce viral load in COVID-19 patients' saliva 2-4 h after mouthwashing [173,174].…”

Section: Therapeutic Potential Of Oc Against Sars-cov-2mentioning

confidence: 99%

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Bellocchio,

Dipalma,

Inchingolo

et al. 2023

Biomedicines

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and aids in the spread of COVID-19. Angiotensin-converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are two of the numerous factors that promote SARS-CoV-2 infection, expressed by O.C. structures, various mucosa types, and the epithelia of salivary glands. A systemic SARS-CoV-2 infection might result from viral replication in O.C. cells. On the other hand, cellular damage of different subtypes in the O.C. might be associated with various clinical signs and symptoms. Factors interfering with SARS-CoV-2 infection potential might represent fertile ground for possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the O.C., finally representing a way to reduce COVID-19 incidence and severity.

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Section: Therapeutic Potential Of Oc Against Sars-cov-2mentioning

confidence: 99%

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Bellocchio,

Dipalma,

Inchingolo

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…This includes household and healthcare settings that perform aerosol-generating procedures. Virucidal effects have been seen in substances contained in oral antiseptics [ 13 , 14 , 15 ]. Interestingly, animal models observing SARS-CoV-1, a virus similar in genomics to SARS-CoV-2, showed that the virus persisted in oral mucous membranes for up to 2 days before infecting the lower respiratory tract [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review

Ting,

Dahlkemper,

Schwartz

et al. 2023

Biomedicines

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(1) There are limited clinical trials to support the effectiveness of mouth rinses when used as a preprocedural rinse against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This systematic review aims to evaluate the efficacy of antiseptic mouth rinses as a preprocedural rinse in reducing SARS-CoV-2 oral viral load in-vivo. (2) Methods: A literature search was conducted through November 2022 for the following databases: PubMed, Web of Science, Cochrane Library, and Google Scholar. The evaluated outcomes were quantitative changes in viral load and the statistical significance of that change after using antiseptic mouth rinses. (3) Results: 14 randomized controlled trials (RCT) were selected for risk of bias assessment and data extraction. (4) Conclusion: Within the limits of this systematic review, preprocedural mouth rinses may significantly reduce SARS-CoV-2 in the mouth, thus, reducing the viral particles available for airborne dispersion. Preprocedural mouth rinses may be an effective strategy for reducing airborne SARS-CoV-2 dispersion in the environment. Their use may be a preventive strategy to reduce the spread of COVID-19 in selected medical and healthcare facilities, including dental clinics. Potential preprocedural mouth rinses are identified for use as an integral part of safe practice for healthcare protocols. This systematic review was registered with the National Institute for Health Research, international prospective register of systematic reviews (PROSPERO): CRD42022315177.

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Evaluation of the dynamics of oral pathogenic microbiota in COVID-19 patients by genomic sequencing after application of foam with antimicrobial action

Yanushevich,

Krikheli,

Maev

et al. 2024

Medicinskij alfavit

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Relevance. The COVID-19 pandemic caused by the SARS-CoV-2 virus has demonstrated the critical importance of understanding the mechanisms of transmission and finding effective methods of prevention. Particular attention has been paid to the role of oral hygiene, as the oral cavity serves as a major route of transmission. Studies show that the composition of the oral microbiota can influence the course and outcome of COVID-19 disease. Therefore, there is a need to study the effects of oral antiseptics on the microbiome, which may offer new opportunities for the prevention and treatment of this disease.Objective. The aim of this study is to evaluate the effectiveness of the oral cleansing foam «Parodontol PROF» in reducing the pathogenic microflora of the oral cavity in patients with COVID-19 and to assess its effect on the risk of secondary infections.Materials and methods. The study was conducted on the basis of the Clinical Medical Centre «Kuskovo» of Russian University of Medicine. It included 450 patients with a confirmed diagnosis of COVID-19. The participants were divided into two groups: the test group used oral cleansing foam, while the control group used no additional oral hygiene. Comparative analyses of the taxonomic composition of the oropharyngeal microbiota and dental plaque before and after the use of the cleansing foam were performed.Results. The study showed that patients who regularly used the cleansing foam «Parodontol PROF» had a significant decrease in the representation of pathogens, including Mycoplasma, and an increase in the number of beneficial commensals such as Lactococcus and Lactobacillus. These changes indicate the potential efficacy of this product to improve oral hygiene and reduce the risk of secondary infections.Conclusion. The study supports the hypothesis that improving oral hygiene with specialised antiseptic agents, such as a cleansing foam, may help to reduce pathogenic microflora in the oral cavity in patients with COVID-19. This, in turn, may reduce the risk of pathogen migration into the lower respiratory tract and the development of secondary infections. The findings emphasise the importance of further research in this area and the development of comprehensive approaches to oral hygiene management in the context of infectious diseases.

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Evaluation of Current Evidence on the Use of Oral Antiseptics Against SARS-CoV-2

Cited by 4 publications

References 39 publications

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review

Evaluation of the dynamics of oral pathogenic microbiota in COVID-19 patients by genomic sequencing after application of foam with antimicrobial action

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