Evaluation of Cuspidaria pulchra and its Isolated Compounds Against Schistosoma mansoni Adult Worms

Pauletti,

doi:10.6000/1927-3037/2012.01.02.03

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Therefore, the commercially available cosmetic products (1376) consist of allantoin at a concentration of 2% [28]. The other compounds isolated from Onosma bourgaei were 3,4-dihydroxybenzaldehyde (2) [29], luteolin-7-O-glucoside (3) [30], apigenin-7-O-β-glucoside (4) [31], diosmetin-7-O-β-glucoside (5) [32], rosmarinic acid (6) [33], globoidnan A ( 7) [34]. The spectral analyses and comparison of the spectral values with the reported data con rmed the proposed structures.…”

Section: Isolation and Identi Cation Of Natural Compoundsmentioning

confidence: 99%

Antiproliferative and cytotoxic effects of bioactive compounds isolated from Onosma bourgaei

et al. 2022

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Onosma species have been used commonly for traditional medicine for years due to their bioactive compounds content. Onosma bourgaei aerial part was extracted with hexane and methanol successively. The methanol extract was subjected to chromatographic techniques to isolate allantoin (1), 3,4dihydroxybenzaldehyde (2), luteolin-7-O-glucoside (3), apigenin-7-O-β-glucoside (4), diosmetin-7-O-βglucoside (5), rosmarinic acid (6), globoidnan A (7). The structure of isolated compounds were identi ed by spectroscopic techniques such as 1D-NMR, 2D-NMR, FTIR, and LC-TOF/MS/MS. Antiproliferative activity of extract and natural compounds were carried out using HeLa (human epithelial cervix adenocarcinoma, ATCC® CCL-2™), HT-29 (human colorectal adenocarcinoma, ATCC® HTB38™), MCF-7 (human mammary gland adenocarcinoma, ATCC® HTB22™) and A549 (human lung carcinoma, ATCC® CCL185™) cancerous cells and normal cells, FL (human epithelial amnion cell, ATCC® CCL62™). Lactate dehydrogenase (LDH) was performed for cytotoxicity. The compounds, 4, 6, and 7 displayed the strong antiproliferative activity against corresponding cell lines. Apigenin-7-O-β-glucoside (4) revealed the excellent activity on HeLa, HT29, A549, MCF6 cancer cell lines with the values of (IC 50, µM) 167.3, 196.8 181.1, 203.5 respectively compared standard compound, cisplatin.

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Section: Isolation and Identi Cation Of Natural Compoundsmentioning

confidence: 99%

Antiproliferative and cytotoxic effects of bioactive compounds isolated from Onosma bourgaei

et al. 2022

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Schistosomicidal Activity of Alkyl-phenols from the Cashew Anacardium occidentale against Schistosoma mansoni Adult Worms

Alvarenga

Oliveira

Souza

et al. 2016

J. Agric. Food Chem.

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Bioassay-guided study of the ethanol extract from the cashew Anacardium occidentale furnished cardol triene (1), cardol diene (2), anacardic acid triene (3), cardol monoene (4), anacardic acid diene (5), 2-methylcardol triene (6), and 2-methylcardol diene (7). 1D- and 2D-NMR experiments and HRMS analysis confirmed the structures of compounds 1-7. Compounds 2 and 7 were active against Schistosoma mansoni adult worms in vitro, with LC values of 32.2 and 14.5 μM and selectivity indices of 6.1 and 21.2, respectively. Scanning electron microscopy of the tegument of male worms in the presence of compound 7 at 25 μM after 24 h of incubation showed severe damage as well as peeling and reduction in the number of spine tubercles. Transmission electron microscopy analyses revealed swollen mitochondrial membrane, vacuoles, and altered tegument in worms incubated with compound 2 (25 μM after 24 h). Worms incubated with compound 7 (25 μM after 24 h) had lysed interstitial tissue, degenerated mitochondria, and drastically altered tegument. Together, the results indicated that compound 7 presents promising in vitro schistosomicidal activity.

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A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

et al. 2022

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The genus Arrabidaea, consisting of ~170 species, belongs to the family Bignoniaceae, distributed around the Neotropics and temperate zone. The center of diversity of the family is in Brazil, where 56 genera and about 340 species exist. Most species of the genus Arrabidaea are traditionally utilized as diuretics and antiseptics, as well as for treating intestinal colic, diarrhea, kidney stones, rheumatoid arthritis, wounds, and enterocolitis. The genus is chemically diverse with different substance classes; most of them are triterpenes, phenolic acids, and flavonoids, and they exhibit valuable pharmacological properties, such as antitumor, antioxidant, leishmanicidal, trypanocidal, anti-inflammatory, and healing properties. This review presents information on the chemical constituents isolated from seven Arrabidaea species, and the pharmacological activities of the extracts, fractions and pure substances isolated since 1994, obtained from electronic databases. The various constituents present in the different species of this genus demonstrate a wide pharmacological potential for the development of new therapeutic agents, however its potential has been underestimated.

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Evaluation of Cuspidaria pulchra and its Isolated Compounds Against Schistosoma mansoni Adult Worms

Cited by 3 publications

References 21 publications

Antiproliferative and cytotoxic effects of bioactive compounds isolated from Onosma bourgaei

Antiproliferative and cytotoxic effects of bioactive compounds isolated from Onosma bourgaei

Schistosomicidal Activity of Alkyl-phenols from the Cashew Anacardium occidentale against Schistosoma mansoni Adult Worms

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

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